DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and Zbtb38

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001012489.2	Gene:	Zbtb38 / 315936	RGDID:	1310136	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	938	Identity:	193/938 - (20%)
Similarity:	317/938 - (33%)	Gaps:	254/938 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VLEISPNINYTVSGESMPYLLSTDGSLAVQKDVKGLTAGGKNNVVRRMFVVNDPSF--PPGTQRV 89
            |||:. ::...|..|.:.|:.|:...:..|:.|..|.|.||...:..:..::|.:|  .||...|
  Rat    73 VLELD-DLKAEVFTEILNYIYSSTVVVRRQETVTDLAAAGKRLGISFLEDLSDRNFSNSPGPYVV 136

  Fly    90 -ITAGGASTVVKKQDNNQQVLSLDKNYLLVDPATAAAAAAAAGGDSGLAHHHTLTNG-------S 146
             ||..|   |||::.|       :|.:  .:||                    :|||       |
  Rat   137 CITEKG---VVKEEKN-------EKRH--EEPA--------------------VTNGPRITNAFS 169

  Fly   147 IVDAKTGQTVLTAGS--AAAKSHFSSIGALHLTQEE---CNEILIKRAIAAGHHQTHTITAADGS 206
            |::.:...::.:...  |:.|....::....|.||.   |.|....|.:|...:...:||.|..|
  Rat   170 IIETENSNSMFSPLDLRASFKKVSDAMRTTSLCQERASVCPEAEPVRTLAEHSYAVSSITEAYRS 234

  Fly   207 ----HHHASGGTPSFCSVGGATTLLGDILPGISVQVQKVIQGLEDNEDSQGEAPNLKLEPGTLEL 267
                .|.:|       |..|.|                   |.|:     |||...|.:|..
  Rat   235 QPLREHDSS-------SSSGKT-------------------GKEN-----GEALTTKAKPCR--- 265

  Fly   268 SPKTELQESMHFSE-------TDATIKKER-PYSCDECGKSFLLKH----------HLTTHARVH 314
            .|||:.|:|...:|       |...:.:|| |....      :|.|          |........
  Rat   266 KPKTQTQDSDSTTENMPLPLVTCPEVNQERSPQPAP------ILSHSEPPSSEGDVHFPREDENQ 324

  Fly   315 TGERP-----------HICTHCGKSFAHKHCLNTHLLLHS-TERPYQCQECKKSFTLKHHLLTHS 367
            ..|.|           :.|:.|.|||.....|..|:.||. |:.|:.|:.|.|.||..:.|..|.
  Rat   325 PSETPGPPAAEVPPLVYNCSCCSKSFDSSTLLGAHMQLHKPTQDPFVCKYCNKQFTTLNRLDRHE 389

  Fly   368 RVHSR---------ERPFV-----CQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENH 418
            ::..|         .:||:     ..:.|.:|.....||..|:.  ||    ....|.:.:..:|
  Rat   390 QICMRSSHMPMPGGNQPFLENYPTIGQDGGSFTSPDSLVPESRI--GE----LSSAGSALSDADH 448

  Fly   419 LIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIHG-KIPHSCTVCGKEFLQKRTLVSHMRR-- 480
            ::   :|......:.|..|..|:.....|..|..:|. :..:.|..|.|.|    .|..:..|
  Rat   449 MV---KFVNGQMLYSCVVCKRSYVTLSSLRRHANVHSWRRTYPCHYCNKVF----ALAEYRTRHE 506

  Fly   481 -VHTGEQAHPCVSCGEGFLTKAELHQH--------------VRTAHNGVNPNTSSATI------- 523
             .||||:.:.|:.|.|.|:|...|..|              .:||:.|:.|......:
  Rat   507 IWHTGERRYQCIFCLETFMTYYILKNHQKSFHAIDHRLSISKKTANGGLKPTVYPYKLYRLLPMR 571

  Fly   524 --------IANQQLQQAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTDANG---------VARP 571
                    ..|...:.|..::...::.|.|. |:.|..:|.:.|::..|...         |..|
  Rat   572 CKRAPYKSYRNSSYESAQGNRQRNESPPDTF-VIPNLPSSEMPTLNFQDGRNSLTSSPAIPVETP 635

  Fly   572 QFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTVVTANPNLVG 636
            .:......:...:.|.|...      .::|.|||......    .:|:...:..|.:.|.|..|.
  Rat   636 SWQGTPTSAKVKNAEGLKWR------KQALKTDLVDSAEV----SISSIGNSVSTTLQAEPVCVS 690

  Fly   637 QSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQ 701
            .......:||.:|.|.|  .:|.::..:.......|:..:.....|...|.||.....:..:.:.
  Rat   691 SGEHSASVISYSGSVPS--VIVHSSQFSSVIKHSNAIACLANSNHQSPSQPVASPSLIKDSKPEA 753

  Fly   702 QQQHVVSVAPANKPKSHFCASCGKG-------FAAKHGLMQHNRRHPNGGCTVRTHVCECGKAFF 759
            .:...::..|.|..:......|.:|       :.|..|          |.....|:|.|
  Rat   754 DKASKLASRPKNSKEKKKTVPCNRGEITEEAKYVADLG----------GSSGKTTNVVE------ 802

  Fly   760 QKNHLMLHQRQHLET---KPAI---SQQQEAATQQQLAT-AGEQQQVQVQIMPDGQIH--GKVIK 815
                    :...:||   |||:   |.....|...|:.. .|.:..|:..|:.....:  |:..|
  Rat   803 --------ETSKIETYIAKPALPGTSTNSNVAPLCQITVKIGNEAIVKRHILGSKLFYKRGRKPK 859

  Fly   816 YEICRNVMPEDQQQE----------QAD 833
            |::....:|.:...|          |||
  Rat   860 YQMQEETLPRESDPETRGDSPLGLCQAD 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	26/106 (25%)
		C2H2 Zn finger	294..314	CDD:275368	3/29 (10%)
		zf-H2C2_2	306..331	CDD:290200	8/35 (23%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		zf-H2C2_2	362..385	CDD:290200	6/36 (17%)
		C2H2 Zn finger	378..398	CDD:275368	5/19 (26%)
		zf-H2C2_2	390..415	CDD:290200	6/24 (25%)
		C2H2 Zn finger	406..426	CDD:275368	2/19 (11%)
		SIR2	<425..>465	CDD:294129	8/40 (20%)
		C2H2 Zn finger	434..454	CDD:275368	5/19 (26%)
		C2H2 Zn finger	461..482	CDD:275368	6/23 (26%)
		C2H2 Zn finger	490..509	CDD:275368	7/32 (22%)
		lambda-1	491..>603	CDD:212564	24/149 (16%)
		C2H2 Zn finger	575..595	CDD:275368	2/19 (11%)
		C2H2 Zn finger	720..740	CDD:275368	4/26 (15%)
		C2H2 Zn finger	752..771	CDD:275368	1/18 (6%)
Zbtb38	NP_001012489.2	BTB_POZ_ZBTB38_CIBZ	15..128	CDD:349532	14/55 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..334		29/143 (20%)
		Interaction with CBFA2T3. /evidence=ECO:0000250\|UniProtKB:Q8NAP3	299..522		54/241 (22%)
		zf-C2H2_8	308..401	CDD:406359	22/92 (24%)
		C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		C2H2 Zn finger	372..391	CDD:275368	7/18 (39%)
		C2H2 Zn finger	461..481	CDD:275368	5/19 (26%)
		C2H2 Zn finger	489..509	CDD:275368	6/23 (26%)
		C2H2 Zn finger	517..535	CDD:275368	7/17 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..644		11/63 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	731..776		6/44 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	857..882		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..914
		C2H2 Zn finger	1019..1039	CDD:275368
		zf-H2C2_2	1032..1055	CDD:404364
		zf-C2H2	1045..1067	CDD:395048
		C2H2 Zn finger	1047..1067	CDD:275368
		C2H2 Zn finger	1075..1095	CDD:275368
		zf-H2C2_2	1088..1112	CDD:404364
		C2H2 Zn finger	1103..1123	CDD:275368
		C2H2 Zn finger	1134..1154	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1172..1203
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100