DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and REPIN1

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001374966.1	Gene:	REPIN1 / 29803	HGNCID:	17922	Length:	626	Species:	Homo sapiens

Alignment Length:	706	Identity:	174/706 - (24%)
Similarity:	230/706 - (32%)	Gaps:	269/706 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LTAGGKNNVVRRMFVVNDPSFPPGTQRVITAGGASTVVKKQD---NNQQVLSLDKNYLLVDPATA 123
            ||.||..:|              |..|..:.|.....:.|:.   .:.|:.||.:...:::....
Human    16 LTPGGYRSV--------------GRSRRCSRGSIPRNIPKRSWKKPHPQLCSLQEEEPMLERRCR 66

  Fly   124 AAAAAAAGGDSGLAHHHTLTNGSIVDAKT-----------GQTVLTAGSAA---------AKSHF 168
            ...|      .|||....|:..|....:|           |.:|..:|:.|         .:.||
Human    67 GPLA------MGLAQPRLLSGPSQESPQTLGKESRGLRQQGTSVAQSGAQAPGRAHRCAHCRRHF 125

  Fly   169 SSIGALHLTQEECNEIL----------IKRA-IAAGHHQTHTITAAD------------------ 204
            ....||.|....|...|          .:.| ..|.|.|.|.....|
Human   126 PGWVALWLHTRRCQARLPLPCPECGRRFRHAPFLALHRQVHAAATPDLGFACHLCGQSFRGWVAL 190

  Fly   205 ----------------------------------GSHHHASGGTPSFCSVGGATTLLGDILPGIS 235
                                              ..|..|....|..|...|.:....|     .
Human   191 VLHLRAHSAAKRPIACPKCERRFWRRKQLRAHLRRCHPPAPEARPFICGNCGRSFAQWD-----Q 250

  Fly   236 VQVQKVIQGLEDNEDSQGEA--PNLKLEPGTLELSPKTELQESMHFSETDATIKKERPYSCDECG 298
            :...|.:...|..|::..:|  |..:..|......|           ..||.   :||:.|..||
Human   251 LVAHKRVHVAEALEEAAAKALGPRPRGRPAVTAPRP-----------GGDAV---DRPFQCACCG 301

  Fly   299 KSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHL 363
            |.|..|.:|..|.|||||||||.|..|||.|.:|..|.:|..:|:.|:||.|:||.:.|..|.:|
Human   302 KRFRHKPNLIAHRRVHTGERPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCKECGRRFRHKPNL 366

  Fly   364 LTHSRVHSR-------------------------------------------------------- 372
            |:||::|.|
Human   367 LSHSKIHKRSEGSAQAAPGPGSPQLPAGPQESAAEPTPAVPLKPAQEPPPGAPPEHPQDPIEAPP 431

  Fly   373 ---------------------------ERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECG 410
                                       ||||.|.|||:.|..|.|||.||:.|:||||:.|||||
Human   432 SLYSCDDCGRSFRLERFLRAHQRQHTGERPFTCAECGKNFGKKTHLVAHSRVHSGERPFACEECG 496

  Fly   411 ESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIH-GKIPHSCTVCGKEFLQKRTL 474
            ..|:|.:||..|.|.|....||||.:||.:|..|..|..|.||| |:.|:.|..|||.|.||..|
Human   497 RRFSQGSHLAAHRRDHAPDRPFVCPDCGKAFRHKPYLAAHRRIHTGEKPYVCPDCGKAFSQKSNL 561

  Fly   475 VSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQAGQ 539
            ||| ||:||||:.:.|..|...|..|:.|..| |.:|
Human   562 VSH-RRIHTGERPYACPDCDRSFSQKSNLITH-RKSH---------------------------- 596

  Fly   540 QTHPQTITVVSNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLH 595
                                        :....|.|..||..|:..|.|..|.:.|
Human   597 ----------------------------IRDGAFCCAICGQTFDDEERLLAHQKKH 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	40/83 (48%)
		C2H2 Zn finger	294..314	CDD:275368	9/19 (47%)
		zf-H2C2_2	306..331	CDD:290200	16/24 (67%)
		C2H2 Zn finger	322..342	CDD:275368	8/19 (42%)
		C2H2 Zn finger	350..370	CDD:275368	9/19 (47%)
		zf-H2C2_2	362..385	CDD:290200	14/105 (13%)
		C2H2 Zn finger	378..398	CDD:275368	11/19 (58%)
		zf-H2C2_2	390..415	CDD:290200	16/24 (67%)
		C2H2 Zn finger	406..426	CDD:275368	11/19 (58%)
		SIR2	<425..>465	CDD:294129	17/40 (43%)
		C2H2 Zn finger	434..454	CDD:275368	8/19 (42%)
		C2H2 Zn finger	461..482	CDD:275368	13/20 (65%)
		C2H2 Zn finger	490..509	CDD:275368	6/18 (33%)
		lambda-1	491..>603	CDD:212564	16/105 (15%)
		C2H2 Zn finger	575..595	CDD:275368	7/19 (37%)
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
REPIN1	NP_001374966.1	C2H2 Zn finger	118..138	CDD:275368	5/19 (26%)
		C2H2 Zn finger	146..166	CDD:275368	4/19 (21%)
		C2H2 Zn finger	177..197	CDD:275368	0/19 (0%)
		COG5048	<197..371	CDD:227381	54/192 (28%)
		C2H2 Zn finger	206..227	CDD:275368	0/20 (0%)
		C2H2 Zn finger	238..258	CDD:275368	4/24 (17%)
		COG5048	292..599	CDD:227381	114/364 (31%)
		C2H2 Zn finger	297..317	CDD:275368	9/19 (47%)
		C2H2 Zn finger	325..345	CDD:275368	8/19 (42%)
		C2H2 Zn finger	353..373	CDD:275368	9/19 (47%)
		C2H2 Zn finger	436..456	CDD:275368	0/19 (0%)
		C2H2 Zn finger	464..484	CDD:275368	11/19 (58%)
		C2H2 Zn finger	492..512	CDD:275368	11/19 (58%)
		C2H2 Zn finger	520..540	CDD:275368	8/19 (42%)
		C2H2 Zn finger	548..568	CDD:275368	13/20 (65%)
		C2H2 Zn finger	576..596	CDD:275368	7/20 (35%)
		C2H2 Zn finger	604..624	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	1	0.960