DRSC/TRiP Functional Genomics Resources

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Protein Alignment cg and ZNF281

DIOPT Version :10

Sequence 1:NP_001097306.2 Gene:cg / 36571 FlyBaseID:FBgn0000289 Length:837 Species:Drosophila melanogaster
Sequence 2:NP_036614.1 Gene:ZNF281 / 23528 HGNCID:13075 Length:895 Species:Homo sapiens


Alignment Length:928 Identity:195/928 - (21%)
Similarity:322/928 - (34%) Gaps:304/928 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 GGKNNVVRRMFVVNDPSFPPG-----------TQRVITAGGASTVVKKQDNNQQVLSLDKNYLLV 118
            ||..:..||..:  :|:||.|           |.....||.|:      ...|.|||        
Human    31 GGGGSSGRRAEM--EPTFPQGMVMFNHRLPPVTSFTRPAGSAA------PPPQCVLS-------- 79

  Fly   119 DPATAAAAAAAAGGDSGLAHHHTLTNGSIVDAKTGQTVLTAGSAAAKSHFSSIGALHLTQEECNE 183
               ::.:||.||......|...|.....           .|.:||..|..:|.|.|.      :.
Human    80 ---SSTSAAPAAEPPPPPAPDMTFKKEP-----------AASAAAFPSQRTSWGFLQ------SL 124

  Fly   184 ILIKRAIAA------GHHQTHTITAADGSHHHASG-------GTPSFCSVGGATTLLGDILPGIS 235
            :.||:...|      .||..|        |||..|       .:|   .:||.......::..:|
Human   125 VSIKQEKPADPEEQQSHHHHH--------HHHYGGLFAGAEERSP---GLGGGEGGSHGVIQDLS 178

  Fly   236 VQVQKVIQGLEDNEDSQGEAPNLKLEPGTLELSPKTELQESMHFSETDATIKK-ERPYSCDECGK 299
            :..|.|.|     :.:|.....|      |..|.:|:........:.|..:|| :||....:..|
Human   179 ILHQHVQQ-----QPAQHHRDVL------LSSSSRTDDHHGTEEPKQDTNVKKAKRPKPESQGIK 232

  Fly   300 SFLLKHHLTTHARVHTGE--------RPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKS 356
            :.......:..:.|..||        :||||.||..:|...:.|..|:|:|:.|||:||.:|...
Human   233 AKRKPSASSKPSLVGDGEGAILSPSQKPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMG 297

  Fly   357 FTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIM 421
            |..|:.|..|.::||||:||.|.:|...|..|.|:..|.:.|:||:||.|:.|.:.|::.:.|:.
Human   298 FIQKYLLQRHEKIHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLK 362

  Fly   422 HSRFHGS--LNPFVCAECGASFPRKFQLVNH---GRIHGKIPHSCTVCGKEFLQKRTLVSHMRRV 481
            |.|..|.  :.....||.|:|        ||   |.: ..:....|...:...:.:::....:..
Human   363 HRRTCGEVIVKGATSAEPGSS--------NHTNMGNL-AVLSQGNTSSSRRKTKSKSIAIENKEQ 418

  Fly   482 HTGE------------QAH----PCVSCGEGFLTKA--ELHQHV-----------RTAHNGVNPN 517
            .||:            |::    |.||...|.:...  ||.:.|           .|..|.:|..
Human   419 KTGKTNESQISNNINMQSYSVEMPTVSSSGGIIGTGIDELQKRVPKLIFKKGSRKNTDKNYLNFV 483

  Fly   518 TSSATIIANQQLQQAHHHQAGQQTHPQTITVVSNPGNSTL-LTVSTTDANGVARPQFVCRECGSA 581
            :....|:..:.|       :|:.:  .::.:|||....|: |..||:...|         :..|.
Human   484 SPLPDIVGQKSL-------SGKPS--GSLGIVSNNSVETIGLLQSTSGKQG---------QISSN 530

  Fly   582 FNSREALALHLRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTVVTANPNLVGQSPV------ 640
            ::.                      |:..:....:|.|||.|....:... ::|.|..|      
Human   531 YDD----------------------AMQFSKKRRYLPTASSNSAFSINVG-HMVSQQSVIQSAGV 572

  Fly   641 -------PVQIISST---GQVMS------------QTTLVQAANSTHPQ---AVVTAVPTMPVHG 680
                   |:.:|.|:   .::.|            |:.|.|.:|.:..|   ....|.|.:.:|.
Human   573 SVLDNEAPLSLIDSSALNAEIKSCHDKSGIPDEVLQSILDQYSNKSESQKEDPFNIAEPRVDLHT 637

  Fly   681 QQQHLQHVAQQ-----------------QQQQQQQQQ---------------------------- 700
            ..:|.:.|.::                 |:..:..||                            
Human   638 SGEHSELVQEENLSPGTQTPSNDKASMLQEYSKYLQQAFEKSTNASFTLGHGFQFVSLSSPLHNH 702

  Fly   701 ----QQQ------------QHVVSVAPANKPKSHFCASCGKGFAAKHGL------MQHNRRHPNG 743
                ::|            |.|.||.|::.||..|    |..|.::.||      ..|.:..|: 
Human   703 TLFPEKQIYTTSPLECGFGQSVTSVLPSSLPKPPF----GMLFGSQPGLYLSALDATHQQLTPS- 762

  Fly   744 GCTVRTHVCECGKAFFQKNHLMLHQRQHLETKPAISQQQEAATQQQ-----LATAGEQ---QQVQ 800
                            |:...::..:::|||..|.....:..|.|:     .::.|.|   |::.
Human   763 ----------------QELDDLIDSQKNLETSSAFQSSSQKLTSQKEQKNLESSTGFQIPSQELA 811

  Fly   801 VQIMPDGQIHGKVIKYEI 818
            .||.|...|..:. .|:|
Human   812 SQIDPQKDIEPRT-TYQI 828

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cgNP_001097306.2 COG5048 287..>371 CDD:227381 29/92 (32%)
C2H2 Zn finger 294..314 CDD:275368 1/19 (5%)
zf-H2C2_2 306..331 CDD:463886 10/32 (31%)
C2H2 Zn finger 322..342 CDD:275368 7/19 (37%)
C2H2 Zn finger 350..370 CDD:275368 6/19 (32%)
C2H2 Zn finger 378..398 CDD:275368 6/19 (32%)
C2H2 Zn finger 406..426 CDD:275368 6/19 (32%)
C2H2 Zn finger 434..454 CDD:275368 7/22 (32%)
C2H2 Zn finger 461..482 CDD:275368 1/20 (5%)
C2H2 Zn finger 490..509 CDD:275368 6/31 (19%)
C2H2 Zn finger 575..595 CDD:275368 1/19 (5%)
C2H2 Zn finger 720..740 CDD:275368 5/25 (20%)
C2H2 Zn finger 752..771 CDD:275368 1/18 (6%)
ZNF281NP_036614.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44 4/14 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 63..113 16/77 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 130..149 6/26 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..253 16/80 (20%)
zf-C2H2_4 261..283 CDD:464025 9/21 (43%)
C2H2 Zn finger 263..283 CDD:275368 7/19 (37%)
zf-H2C2_2 275..300 CDD:463886 11/24 (46%)
C2H2 Zn finger 291..311 CDD:275368 6/19 (32%)
C2H2 Zn finger 319..339 CDD:275368 6/19 (32%)
zf-H2C2_2 331..356 CDD:463886 10/24 (42%)
C2H2 Zn finger 347..366 CDD:275368 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 377..427 10/58 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 638..660 2/21 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 778..817 8/38 (21%)

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