DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and Zfp341

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_955008.2	Gene:	Zfp341 / 228807	MGIID:	2682937	Length:	846	Species:	Mus musculus

Alignment Length:	591	Identity:	140/591 - (23%)
Similarity:	206/591 - (34%)	Gaps:	161/591 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QNPPPFGYTWGFADNGNRAAESVLEISPNINYTVSGESMPYLLSTDGSLAVQKDVKGLTAGG--- 66
            |.|||...|.|.:...|....||:|:     |..:..     ::.:|::.:|       |.|
Mouse   193 QPPPPPPQTLGPSGRSNPVGNSVVEV-----YNAAAP-----MAGNGTVEIQ-------ALGMQP 240

  Fly    67 ------KNNVVRRMFVVNDPSFPPGTQRVITAGGASTVVKKQDNNQQVLSLDKNYLLVDPATAAA 125
                  .:..|........|.:.||.|.....|.:||..........|.:.|      .|.|...
Mouse   241 YPPLEVPSQCVEAPVYPTPPVYSPGKQEFKPKGPSSTAPMTNATGSTVATFD------SPPTLKT 299

  Fly   126 AAAAAGGDSGLAHHHTLTNGSIVDAKTGQTVLTAGSAAA------------------KSHFSSIG 172
            ..|.  |.|||..                   .||...|                  :.|..|
Mouse   300 RRAK--GASGLPE-------------------AAGKPKAQKLKCSYCDKSFTKNFDLQQHIRS-- 341

  Fly   173 ALHLTQE-----ECNEILIKRAIAAGHHQTHTITAADGSHHHASGGTPSFCSVGGATTLLGDILP 232
              |..::     .|.....:::....|.|||.:....     .||||.|..||
Mouse   342 --HTGEKPFQCIACGRAFAQKSNVKKHMQTHKVWPPG-----RSGGTVSRNSV------------ 387

  Fly   233 GISVQVQKVIQGLEDNEDS---------------------QGEAPNLK----LEPGTL-ELSP-- 269
              :|||..:....::.||:                     :|:.|..|    ::...| :..|
Mouse   388 --TVQVMALNPNRQEEEDTGLGQSLSSTTQPQALPTAGEDEGDKPEAKQVVLIDSSYLCQFCPSK 450

  Fly   270 -KTELQESMHFSETDATIKKERPYSC--DECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAH 331
             .|..|...|..:.    |||:.|.|  ..|.:.|........|.|.|..|..:.|..|.|.|..
Mouse   451 FSTYFQLKSHMIQH----KKEQVYKCVVKSCAQMFPKLDTFLEHIRSHQEELSYRCHLCSKDFPS 511

  Fly   332 KHCLNTHLLLHS---------TERPYQCQECKKSFT----LKHHLLTHSRVHSRERPFVCQECGR 383
            .:.|..|...||         ....|:|.:|...::    |:||:.|  ..||    |.|..|.:
Mouse   512 LYDLGVHQYSHSLLPQHSPKKDSTVYKCVKCVNKYSTPEALEHHVQT--ATHS----FPCPHCQK 570

  Fly   384 AFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLV 448
            .||.:|:|..|...|.....:.|:.|.:.|.:|::|.:|:..|....|:.|:.|.::|.||.:|.
Mouse   571 VFPCERYLRRHLPTHGSGGRFRCQICKKFFRKEHYLKLHAHIHSGEKPYKCSVCESAFNRKDKLK 635

  Fly   449 NHGRIHG-----KIPHSC-TVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHV 507
            .|..||.     |.|.|. |.|.|||.::..|.:|:.. |.|.:.|.|..|.:.|..:|.|.:|.
Mouse   636 RHMLIHEPFKKYKCPFSMHTGCSKEFNRQDKLKAHILS-HAGLKLHKCGLCSKSFSRRAHLAEHQ 699

  Fly   508 RTAHNG 513
            | ||.|
Mouse   700 R-AHTG 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	26/98 (27%)
		C2H2 Zn finger	294..314	CDD:275368	5/21 (24%)
		zf-H2C2_2	306..331	CDD:290200	8/24 (33%)
		C2H2 Zn finger	322..342	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368	6/23 (26%)
		zf-H2C2_2	362..385	CDD:290200	7/22 (32%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		zf-H2C2_2	390..415	CDD:290200	6/24 (25%)
		C2H2 Zn finger	406..426	CDD:275368	6/19 (32%)
		SIR2	<425..>465	CDD:294129	15/45 (33%)
		C2H2 Zn finger	434..454	CDD:275368	7/19 (37%)
		C2H2 Zn finger	461..482	CDD:275368	7/21 (33%)
		C2H2 Zn finger	490..509	CDD:275368	6/18 (33%)
		lambda-1	491..>603	CDD:212564	9/23 (39%)
		C2H2 Zn finger	575..595	CDD:275368
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
Zfp341	NP_955008.2	COG5048	321..726	CDD:227381	105/419 (25%)
		zf-C2H2	321..342	CDD:278523	2/24 (8%)
		C2H2 Zn finger	322..342	CDD:275368	2/23 (9%)
		zf-H2C2_2	334..359	CDD:290200	4/28 (14%)
		C2H2 Zn finger	350..370	CDD:275368	3/19 (16%)
		C2H2 Zn finger	444..464	CDD:275368	4/19 (21%)
		C2H2 Zn finger	472..494	CDD:275368	5/21 (24%)
		C2H2 Zn finger	502..522	CDD:275368	6/19 (32%)
		C2H2 Zn finger	539..561	CDD:275370	6/23 (26%)
		C2H2 Zn finger	565..585	CDD:275368	7/19 (37%)
		C2H2 Zn finger	593..613	CDD:275368	6/19 (32%)
		zf-H2C2_2	605..630	CDD:290200	7/24 (29%)
		C2H2 Zn finger	621..641	CDD:275368	7/19 (37%)
		C2H2 Zn finger	649..674	CDD:275368	9/25 (36%)
		C2H2 Zn finger	682..702	CDD:275368	7/20 (35%)
		C2H2 Zn finger	710..727	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100