DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and Zfp523

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001344924.1	Gene:	Zfp523 / 224656	MGIID:	2687278	Length:	568	Species:	Mus musculus

Alignment Length:	649	Identity:	169/649 - (26%)
Similarity:	251/649 - (38%)	Gaps:	160/649 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 LVDPATAAAAAAAAGGDSGLAHHHTLTNGSIVDAKTGQTVLTAGSAAAKSHFS------------ 169
            |.|..||....|..|        ..|..|.::..:.|.|.........|..||
Mouse    11 LSDGTTAYVQQAVKG--------EKLLEGQVIQLEDGTTAYIHQVTIQKESFSFEDGQPVQLEDG 67

  Fly   170 SIGALHLTQEE-CNEILIKRAIAAGHHQTHTITAADGS----HHHASGGTPSFCSVGGATTLLGD 229
            |:..:|.|.:| |:...::           .:...|||    ||...  .||..::
Mouse    68 SMAYIHHTPKEGCDPSALE-----------AVQLEDGSTAYIHHPVP--VPSDSAI--------- 110

  Fly   230 ILPGISVQVQKVIQGLED--NEDSQGEAPNLKLEPGTLELSPKTELQESMHFSETDATIKKERPY 292
                ::||.:   .||||  .||.:|...:..:   .||......|.:|............:|.:
Mouse   111 ----LAVQTE---AGLEDLAAEDEEGFGTDTVV---ALEQYASKVLHDSPASHNGKGQQVGDRAF 165

  Fly   293 SC--DECGKSFLLKHHLTTHARVHTGERPHIC--THCGKSFAHKHCLNTHLLLHSTERPYQCQE- 352
            .|  ..||:.:...|||..|.|.|||:||:.|  ..|||:||..:.|.:|:..|:.|:||:|.|
Mouse   166 RCGYKGCGRLYTTAHHLKVHERAHTGDRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEE 230

  Fly   353 -CKKSFTLKHHLLTHSRVHSRERPFVC--QECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFA 414
             |.|:|.....|..|.|.|:.||||.|  :.|||:|........|.:.|.|||||.|.|
Mouse   231 LCSKAFKTSGDLQKHVRTHTGERPFRCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPE------ 289

  Fly   415 QENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIH-GKIPHSCTV--CGKEFLQKRTLVS 476
                                ..||..|.......||.||| |:.|:.|||  |||.|.:..:|..
Mouse   290 --------------------PHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYK 334

  Fly   477 HMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQ------------- 528
            | ..|||..:.:.|.|||:.:...:.|..|.|:||..:.....|...:..||
Mouse   335 H-HVVHTHCKPYTCSSCGKTYRQTSTLAMHKRSAHGELEATEESEQALYEQQQLEAASAAEESPP 398

  Fly   529 --------LQQAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSR 585
                    |.:.....:...|....:|....|....|:|...|....:: |:.: :..|||.
Mouse   399 PKPTHIAYLSEVKEESSAIPTQVAMVTEEDGPPQVALITQDGTQQVSLS-PEDL-QALGSAI--- 458

  Fly   586 EALALHLRLHTGDKSLMTDLCALTAALPGHF--LSTASLNPGTVVTANPNLVGQSPVPVQIISST 648
                          |::|...:.|..:|||.  |:|:..:..|:|:|:    |....||.||:|
Mouse   459 --------------SVVTQHGSTTLTIPGHHEELATSGTHTVTMVSAD----GTQTQPVTIITS- 504

  Fly   649 GQVMSQTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHVVSVAPA 712
            |.::::.:.|  |:..|.|..:.|.    .:|     .|:|.|.:.||..::     .:|||.|
Mouse   505 GALVTEDSSV--ASLHHQQVALLAT----ANG-----THIAVQLEDQQTLEE-----AISVATA 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	34/89 (38%)
		C2H2 Zn finger	294..314	CDD:275368	8/21 (38%)
		zf-H2C2_2	306..331	CDD:290200	14/26 (54%)
		C2H2 Zn finger	322..342	CDD:275368	8/21 (38%)
		C2H2 Zn finger	350..370	CDD:275368	8/21 (38%)
		zf-H2C2_2	362..385	CDD:290200	12/24 (50%)
		C2H2 Zn finger	378..398	CDD:275368	6/21 (29%)
		zf-H2C2_2	390..415	CDD:290200	9/24 (38%)
		C2H2 Zn finger	406..426	CDD:275368	2/19 (11%)
		SIR2	<425..>465	CDD:294129	13/42 (31%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		C2H2 Zn finger	461..482	CDD:275368	9/22 (41%)
		C2H2 Zn finger	490..509	CDD:275368	6/18 (33%)
		lambda-1	491..>603	CDD:212564	23/132 (17%)
		C2H2 Zn finger	575..595	CDD:275368	3/19 (16%)
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
Zfp523	NP_001344924.1	3 X 12 AA approximate repeats	34..99		13/75 (17%)
		C2H2 Zn finger	167..189	CDD:275368	8/21 (38%)
		COG5048	<179..366	CDD:227381	77/213 (36%)
		C2H2 Zn finger	197..219	CDD:275368	8/21 (38%)
		C2H2 Zn finger	227..249	CDD:275368	8/21 (38%)
		C2H2 Zn finger	257..279	CDD:275368	6/21 (29%)
		C2H2 Zn finger	287..309	CDD:275368	8/47 (17%)
		C2H2 Zn finger	317..339	CDD:275368	9/22 (41%)
		C2H2 Zn finger	347..365	CDD:275368	6/17 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..402		6/36 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000