DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and Y5F2A.4

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_502063.1	Gene:	Y5F2A.4 / 178004	WormBaseID:	WBGene00012385	Length:	454	Species:	Caenorhabditis elegans

Alignment Length:	305	Identity:	82/305 - (26%)
Similarity:	122/305 - (40%)	Gaps:	86/305 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 YSCDECGKSFLLKHHLTTH-ARVH----------TGERPHICTHCGKSFAHKHCLNTHLLLHSTE 345
            :.|.:|||:|.||.:||.| .|:|          :...|..|:.|.|.|.....|..|.:.|...
Worm     4 HKCQDCGKTFDLKRYLTKHELRMHKNVVKSKNDRSASDPLKCSMCDKVFPRLSHLQRHQMTHLNV 68

  Fly   346 RPYQCQECKKSFTLKHHLLTH-SRVHSRERPFV------CQECGRAF----PLKRHLVTHSKFHA 399
            |.|.|..|::.|..|.||..| ||.|| ..|.|      |.:||:.|    .::.|..|:.:.|.
Worm    69 RNYSCTFCEEKFVQKSHLTRHVSRKHS-NAPGVEVDWTACDKCGQLFKTTYEMRIHRQTYHELHK 132

  Fly   400 GERPYVCEEC------GESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIHGKIP 458
                  |::|      |....:::|  |..|.:.:    ||.||||||.|...||:|.
Worm   133 ------CKQCQEVIEAGSDGLRKHH--MQCRKYSN----VCDECGASFSRPADLVSHE------- 178

  Fly   459 HSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNP-NTSSAT 522
               |.|.|:|                  |..|..|...|..:.:|.:|::.||  .:| ..|...
Worm   179 ---TSCLKKF------------------AFVCKPCDSYFRQRVQLDRHIKKAH--FHPTKCSKCE 220

  Fly   523 IIANQQLQQAHHHQAGQQTHPQTITVV-------SNPGNSTLLTV 560
            .|::..:|.:.|..       :.:.|:       .||..:.:.||
Worm   221 QISDTPVQNSRHSL-------ECVKVIICGYCSLKNPDKNHVATV 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	31/90 (34%)
		C2H2 Zn finger	294..314	CDD:275368	11/20 (55%)
		zf-H2C2_2	306..331	CDD:290200	10/35 (29%)
		C2H2 Zn finger	322..342	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368	9/20 (45%)
		zf-H2C2_2	362..385	CDD:290200	12/29 (41%)
		C2H2 Zn finger	378..398	CDD:275368	6/23 (26%)
		zf-H2C2_2	390..415	CDD:290200	6/30 (20%)
		C2H2 Zn finger	406..426	CDD:275368	6/25 (24%)
		SIR2	<425..>465	CDD:294129	13/39 (33%)
		C2H2 Zn finger	434..454	CDD:275368	11/19 (58%)
		C2H2 Zn finger	461..482	CDD:275368	4/20 (20%)
		C2H2 Zn finger	490..509	CDD:275368	5/18 (28%)
		lambda-1	491..>603	CDD:212564	16/78 (21%)
		C2H2 Zn finger	575..595	CDD:275368
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
Y5F2A.4	NP_502063.1	C2H2 Zn finger	6..27	CDD:275368	11/20 (55%)
		zf-C2H2	44..65	CDD:278523	6/20 (30%)
		C2H2 Zn finger	45..65	CDD:275368	6/19 (32%)
		C2H2 Zn finger	73..94	CDD:275368	9/20 (45%)
		C2H2 Zn finger	107..126	CDD:275368	5/18 (28%)
		C2H2 Zn finger	161..181	CDD:275368	12/29 (41%)
		C2H2 Zn finger	189..212	CDD:275368	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000