DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and ZNF467

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_011514159.1	Gene:	ZNF467 / 168544	HGNCID:	23154	Length:	809	Species:	Homo sapiens

Alignment Length:	791	Identity:	204/791 - (25%)
Similarity:	287/791 - (36%)	Gaps:	236/791 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 PSFPPGTQRVITAGGASTVVKKQDNNQQVLSLDKNYLLVDPATAAAAA--AAAGGDSGLAHHHTL 142
            ||.||..|.......:..|..........||:.:::....|...||:|  :.|||..|
Human   164 PSVPPPLQAPFPGFDSPRVYPSPPREVSGLSVCQSFRPSAPELQAASAIVSRAGGAGG------- 221

  Fly   143 TNGSIVDAKTGQTVLTAGSAAAKSHFSSI-------GALHLTQEECNEILIKRAIAAGH-HQTHT 199
             .|:.|.|           |.|:...|.:       ..|.:|..|..|.|.....:.|. .....
Human   222 -PGAWVPA-----------ARAERPASQVLWPDPQEELLWVTMRETLEALSSLGFSVGQPEMAPQ 274

  Fly   200 ITAADGSHHHASGGTPSFCSVGGATTLLGDILPGISVQVQKVIQGLEDNEDSQGE---------- 254
            ....:|||:     .....|.......|| :..|....::||  .:|| ||.:.|
Human   275 SEPREGSHN-----AQEQMSSSREERALG-VCSGEEWMIRKV--KVED-EDQEAEEEVEWPQHLS 330

  Fly   255 -------APNL-------KLEPGT------LELSPKTELQESMHFSETDATIKKERPYSCDECGK 299
                   ||:|       |||||.      |.||....:              .|:||.|.||.:
Human   331 LLPSPFPAPDLGHLAAAYKLEPGAPGALSGLALSGWGPM--------------PEKPYGCGECER 381

  Fly   300 SFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHST----ERPYQCQECKKSFTLK 360
            .|..:..|..|.|:|.||.|..|..||:||..:    .|:|||..    |||:.|.||.|.|:.|
Human   382 RFRDQLTLRLHQRLHRGEGPCACPDCGRSFTQR----AHMLLHQRSHRGERPFPCSECDKRFSKK 442

  Fly   361 HHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRF 425
            .||..|.|.|:.|||:.|.|||:.|..|.||.:|.|.|.||||:.|.||.:.|.::.|||.|.|.
Human   443 AHLTRHLRTHTGERPYPCAECGKRFSQKIHLGSHQKTHTGERPFPCTECEKRFRKKTHLIRHQRI 507

  Fly   426 HGSLNPFVCAECGASFPRKFQLVNHGRIH----------------------------GKIPHSCT 462
            |....|:.||:|..||..|..||.|.|:|                            |..|.:|:
Human   508 HTGERPYQCAQCARSFTHKQHLVRHQRVHQTAGPARPSPDSSASPHSTAPSPTPSFPGPKPFACS 572

  Fly   463 VCGKEFLQKRTLVSHMRRVHTGE-QAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIAN 526
            .||..|..|:.|.:| :.:|..| :...|..|..|....|...:.:.:|..|......|..::.
Human   573 DCGLSFGWKKNLATH-QCLHRSEGRPFGCDECALGATVDAPAAKPLASAPGGPGCGPGSDPVVP- 635

  Fly   527 QQLQQAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALH 591
               |:|   .:|:::                               |.|.:||..|:..:.||.|
Human   636 ---QRA---PSGERS-------------------------------FFCPDCGRGFSHGQHLARH 663

  Fly   592 LRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTVVTANPNLVGQSPVPVQIISSTGQVMSQTT 656
            .|:|||::......|.....                  :.||||..|
Human   664 PRVHTGERPFACTQCDRRFG------------------SRPNLVAHS------------------ 692

  Fly   657 LVQAANSTHPQAVVTAVPTMPVHGQQ-QHLQHVAQQQQQQQQQQQQQQQHVVSVAPANKPKSHFC 720
              :|.:...|.|....       |:: ....|:.:.|               :|...::|  |.|
Human   693 --RAHSGARPFACAQC-------GRRFSRKSHLGRHQ---------------AVHTGSRP--HAC 731

  Fly   721 ASCGKGFAAKHGLMQHNRRHPNGGCTVRTHVC-ECGKAFFQKNHLMLHQRQHLE----------T 774
            |.|.:.|::|..|::|...|...    |...| :|||:|.:|.||:.||..|.|          .
Human   732 AVCARSFSSKTNLVRHQAIHTGS----RPFSCPQCGKSFSRKTHLVRHQLIHGEAAHAAPDAALA 792

  Fly   775 KPAISQQQEAA 785
            .||.|...|.|
Human   793 APAWSAPPEVA 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	36/87 (41%)
		C2H2 Zn finger	294..314	CDD:275368	7/19 (37%)
		zf-H2C2_2	306..331	CDD:290200	12/24 (50%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	10/19 (53%)
		zf-H2C2_2	362..385	CDD:290200	12/22 (55%)
		C2H2 Zn finger	378..398	CDD:275368	10/19 (53%)
		zf-H2C2_2	390..415	CDD:290200	13/24 (54%)
		C2H2 Zn finger	406..426	CDD:275368	9/19 (47%)
		SIR2	<425..>465	CDD:294129	16/67 (24%)
		C2H2 Zn finger	434..454	CDD:275368	10/19 (53%)
		C2H2 Zn finger	461..482	CDD:275368	7/20 (35%)
		C2H2 Zn finger	490..509	CDD:275368	4/18 (22%)
		lambda-1	491..>603	CDD:212564	21/111 (19%)
		C2H2 Zn finger	575..595	CDD:275368	8/19 (42%)
		C2H2 Zn finger	720..740	CDD:275368	7/19 (37%)
		C2H2 Zn finger	752..771	CDD:275368	10/19 (53%)
ZNF467	XP_011514159.1	C2H2 Zn finger	376..396	CDD:275368	7/19 (37%)
		zf-H2C2_2	389..413	CDD:290200	12/23 (52%)
		COG5048	404..779	CDD:227381	130/483 (27%)
		C2H2 Zn finger	404..424	CDD:275368	9/23 (39%)
		zf-H2C2_2	416..440	CDD:290200	11/23 (48%)
		zf-C2H2	430..452	CDD:278523	10/21 (48%)
		C2H2 Zn finger	432..452	CDD:275368	10/19 (53%)
		zf-H2C2_2	444..469	CDD:290200	13/24 (54%)
		C2H2 Zn finger	460..480	CDD:275368	10/19 (53%)
		zf-H2C2_2	472..495	CDD:290200	12/22 (55%)
		C2H2 Zn finger	488..508	CDD:275368	9/19 (47%)
		zf-H2C2_2	500..525	CDD:290200	12/24 (50%)
		C2H2 Zn finger	516..536	CDD:275368	10/19 (53%)
		C2H2 Zn finger	571..591	CDD:275368	7/20 (35%)
		C2H2 Zn finger	647..667	CDD:275368	8/19 (42%)
		zf-H2C2_2	659..682	CDD:290200	8/22 (36%)
		C2H2 Zn finger	675..695	CDD:275368	6/57 (11%)
		C2H2 Zn finger	703..723	CDD:275368	3/41 (7%)
		C2H2 Zn finger	731..751	CDD:275368	7/19 (37%)
		zf-H2C2_2	743..768	CDD:290200	9/28 (32%)
		C2H2 Zn finger	759..779	CDD:275368	10/19 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	1	0.960