DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and ZNF425

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001001661.1	Gene:	ZNF425 / 155054	HGNCID:	20690	Length:	752	Species:	Homo sapiens

Alignment Length:	555	Identity:	166/555 - (29%)
Similarity:	232/555 - (41%)	Gaps:	111/555 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 KTELQESMHFSETDATIKKERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHC 334
            |:||:      .|...:.:::.:.|.||.||:.||..|.||..||||:||:.|..|.|:|.::..
Human   230 KSELR------RTQRLLCQKKRFQCSECEKSYFLKGSLVTHQVVHTGQRPYPCPECDKTFRYRAN 288

  Fly   335 LNTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHA 399
            |..||.||..|||:.|.||.::|..:..|..|.|:||.|:||.|.:|.|.|.|||.:..|...|:
Human   289 LKKHLCLHRGERPFCCGECGRAFVQQCELTEHLRLHSGEKPFQCPQCDRCFRLKRGMKVHLTQHS 353

  Fly   400 GERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIH-GKIPHSCTV 463
            |:||:.|.|||.||:::..|..|.|.|....||.|.|||..|..|.:|..|.|:| |:.|.||..
Human   354 GKRPFHCPECGRSFSRKAALKTHQRTHSEEKPFSCGECGRKFIYKIKLDEHIRVHTGEKPFSCPE 418

  Fly   464 CGKEFLQKRTLVSH------------------------MR---RVHTGEQAHPCVSCGEGFLTKA 501
            |.|.|..||:|.:|                        ||   |:|:.::..||..||:.|...:
Human   419 CNKSFRLKRSLKAHGLQHIGKRPFQCPECSRGFFWRNAMRAHQRLHSEQKPFPCAECGKRFTRPS 483

  Fly   502 ELHQHVRTAHN-------GVNPNTSSATIIANQQLQQAHHHQAGQQTHPQTITVVSNPGNSTLLT 559
            :|..|.| .|:       |....|.|      ||.:...|                       |.
Human   484 KLACHTR-VHDRQKEFPCGECKKTFS------QQSRLTQH-----------------------LK 518

  Fly   560 VSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLC----ALTAALPGHFLSTA 620
            |.||:     :| |.|.|||.:|..|..|..|.|||:|::......|    :..|::..|.....
Human   519 VHTTE-----KP-FSCAECGRSFRRRAHLTEHTRLHSGEEPFQCPECDKSFSWKASMKFHQRMHR 577

  Fly   621 SLNPGTVVTANPNLVGQSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVHGQ-QQH 684
            ...|......:.....||.:...:...:|:              .|........|..:.|. :.|
Human   578 DEKPFACGECDKTYTHQSQLTEHLRLHSGE--------------KPYQCPECEKTFRLKGNLKSH 628

  Fly   685 -LQHVAQQQ------QQQQQQQQQQQQHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHNRRHPN 742
             |||..|:.      .:...||.:..:| :.|....||..  |..|.|.:..:..|..|..:|..
Human   629 LLQHSGQKPFSCVMCGKSFTQQYRLTEH-IRVHSGEKPFQ--CPECDKSYCIRGSLKVHLYKHSG 690

  Fly   743 GGCTVRTHVC-ECGKAFFQKNHLMLHQRQHLETKP 776
                .|...| ||||.|.||..|..|...|...:|
Human   691 ----ERPFQCPECGKGFLQKRSLKAHLCLHSGERP 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	35/83 (42%)
		C2H2 Zn finger	294..314	CDD:275368	10/19 (53%)
		zf-H2C2_2	306..331	CDD:290200	13/24 (54%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		zf-H2C2_2	362..385	CDD:290200	11/22 (50%)
		C2H2 Zn finger	378..398	CDD:275368	8/19 (42%)
		zf-H2C2_2	390..415	CDD:290200	11/24 (46%)
		C2H2 Zn finger	406..426	CDD:275368	9/19 (47%)
		SIR2	<425..>465	CDD:294129	17/40 (43%)
		C2H2 Zn finger	434..454	CDD:275368	9/19 (47%)
		C2H2 Zn finger	461..482	CDD:275368	11/47 (23%)
		C2H2 Zn finger	490..509	CDD:275368	6/18 (33%)
		lambda-1	491..>603	CDD:212564	31/118 (26%)
		C2H2 Zn finger	575..595	CDD:275368	9/19 (47%)
		C2H2 Zn finger	720..740	CDD:275368	5/19 (26%)
		C2H2 Zn finger	752..771	CDD:275368	10/19 (53%)
ZNF425	NP_001001661.1	KRAB	9..64	CDD:214630
		KRAB	9..48	CDD:279668
		C2H2 Zn finger	192..212	CDD:275368
		C2H2 Zn finger	248..268	CDD:275368	10/19 (53%)
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		C2H2 Zn finger	304..324	CDD:275368	7/19 (37%)
		C2H2 Zn finger	332..352	CDD:275368	8/19 (42%)
		COG5048	355..731	CDD:227381	112/424 (26%)
		zf-C2H2	358..380	CDD:278523	9/21 (43%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	388..408	CDD:275368	9/19 (47%)
		zf-H2C2_2	401..423	CDD:290200	10/21 (48%)
		C2H2 Zn finger	416..432	CDD:275368	7/15 (47%)
		C2H2 Zn finger	444..464	CDD:275368	3/19 (16%)
		C2H2 Zn finger	472..492	CDD:275368	7/20 (35%)
		C2H2 Zn finger	500..520	CDD:275368	7/48 (15%)
		C2H2 Zn finger	528..548	CDD:275368	9/19 (47%)
		zf-H2C2_2	540..564	CDD:290200	7/23 (30%)
		C2H2 Zn finger	556..576	CDD:275368	3/19 (16%)
		C2H2 Zn finger	584..604	CDD:275368	2/19 (11%)
		zf-H2C2_2	597..619	CDD:290200	2/35 (6%)
		C2H2 Zn finger	612..632	CDD:275368	4/19 (21%)
		C2H2 Zn finger	640..660	CDD:275368	3/20 (15%)
		zf-H2C2_2	653..675	CDD:290200	7/24 (29%)
		C2H2 Zn finger	668..688	CDD:275368	5/19 (26%)
		zf-H2C2_2	680..705	CDD:290200	10/28 (36%)
		C2H2 Zn finger	696..716	CDD:275368	10/19 (53%)
		C2H2 Zn finger	724..744	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870