DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and ZNF786

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_689624.2	Gene:	ZNF786 / 136051	HGNCID:	21806	Length:	782	Species:	Homo sapiens

Alignment Length:	672	Identity:	175/672 - (26%)
Similarity:	246/672 - (36%)	Gaps:	179/672 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 KTGQTVLTAGSAAAKSHFSSIGALHLTQEECNEILIKRAIAAGHHQTHT----ITAADGS----H 207
            |..:|.:...|...:.|| ..|.       |.:...::.....|...||    ...|||.    |
Human   223 KRAETQMPWSSPRVQRHF-RCGV-------CGKSFRRKLCLLRHLAAHTGRGPFRNADGEMCFRH 279

  Fly   208 H--HAS------GGTPSFCSVGGATTLLGDILPGISVQVQKVIQGLEDNED-SQGEAPNLKLEPG 263
            .  |.|      |..|:.|:..|..:     ||..|.|.::.....|.... .:|...:..:..|
Human   280 ELTHPSHRLPQQGEKPAQCTPCGKRS-----LPVDSTQARRCQHSREGPASWREGRGASSSVHSG 339

  Fly   264 TLELSPKTEL-QESMHFSETDATIKK---ERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTH 324
            .   .|.:.| ||.....|.|....:   |.|.||.|||:...:...|.:..|.||||:|..|.|
Human   340 Q---KPGSRLPQEGNSHQEGDTEALQHGAEGPCSCSECGERSPMSARLASPCRAHTGEKPFQCAH 401

  Fly   325 CGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKR 389
            |.|.|..:..|..|...|..|||:.|::|.|.|..:..|..|.||||.|:||.|.:|||.|..:.
Human   402 CTKRFRLRRLLQVHQHAHGGERPFSCRKCGKGFAKQCKLTEHIRVHSGEKPFRCAKCGRNFRQRG 466

  Fly   390 HLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIH 454
            .|:.|.:.|..|:|:.|.|||.||..|:.|..|...||...||.|:|||..|..:.:|..|.|:|
Human   467 QLLRHQRLHTDEKPFQCPECGLSFRLESMLRAHRLRHGGERPFSCSECGRGFTHQCKLREHLRVH 531

  Fly   455 -GKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNP-- 516
             |:.|..|..|.|.|..|..|.:| :..|:.|:...|..||:||..:::|.:|:| .|:|..|
Human   532 SGERPFQCLKCDKRFRLKGILKAH-QHTHSKERPFSCGECGKGFTRQSKLTEHLR-VHSGERPFQ 594

  Fly   517 ----NTS---SATIIANQQL------------QQAHHHQAGQQTHPQTITVVSNPGNSTLLTVST 562
                |.|   ...::::|:|            .:.:..:|..:.| |.:.....|
Human   595 CPECNRSFRLKGQLLSHQRLHTGERPFQCPECDKRYRVKADMKAH-QLLHSGEMP---------- 648

  Fly   563 TDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTV 627
                      |.| |||..|.....|..|:|.|||:|......|..:..|....||...|:.|
Human   649 ----------FSC-ECGKGFVKHSKLIEHIRTHTGEKPFQCPKCDKSFRLKAQLLSHQGLHTG-- 700

  Fly   628 VTANPNLVGQSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQHVAQQQ 692
                                                           ..|.|
Human   701 -----------------------------------------------ERPFH------------- 705

  Fly   693 QQQQQQQQQQQQHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHNRRH-PNGGCTVRTHVC-ECG 755
                                       |..|.|.|..:..:::|.|.| |.     |...| :||
Human   706 ---------------------------CPECDKNFRERGHMLRHQRIHRPE-----RPFACGDCG 738

  Fly   756 KAFFQKNHLMLHQRQHLETKPA 777
            |.|..|:.|..|.|.|.::.||
Human   739 KGFIYKSKLAEHIRVHTKSCPA 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	33/86 (38%)
		C2H2 Zn finger	294..314	CDD:275368	6/19 (32%)
		zf-H2C2_2	306..331	CDD:290200	12/24 (50%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		zf-H2C2_2	362..385	CDD:290200	13/22 (59%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		zf-H2C2_2	390..415	CDD:290200	11/24 (46%)
		C2H2 Zn finger	406..426	CDD:275368	9/19 (47%)
		SIR2	<425..>465	CDD:294129	16/40 (40%)
		C2H2 Zn finger	434..454	CDD:275368	8/19 (42%)
		C2H2 Zn finger	461..482	CDD:275368	7/20 (35%)
		C2H2 Zn finger	490..509	CDD:275368	7/18 (39%)
		lambda-1	491..>603	CDD:212564	31/132 (23%)
		C2H2 Zn finger	575..595	CDD:275368	8/19 (42%)
		C2H2 Zn finger	720..740	CDD:275368	6/19 (32%)
		C2H2 Zn finger	752..771	CDD:275368	9/19 (47%)
ZNF786	NP_689624.2	KRAB	9..67	CDD:214630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..164
		C2H2 Zn finger	242..262	CDD:275368	3/26 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..364		18/86 (21%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	399..419	CDD:275368	7/19 (37%)
		C2H2 Zn finger	427..447	CDD:275368	7/19 (37%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		COG5048	<471..722	CDD:227381	81/363 (22%)
		C2H2 Zn finger	483..503	CDD:275368	9/19 (47%)
		C2H2 Zn finger	511..531	CDD:275368	8/19 (42%)
		C2H2 Zn finger	539..559	CDD:275368	7/20 (35%)
		C2H2 Zn finger	567..587	CDD:275368	8/20 (40%)
		C2H2 Zn finger	595..615	CDD:275368	3/19 (16%)
		C2H2 Zn finger	623..643	CDD:275368	3/20 (15%)
		C2H2 Zn finger	652..670	CDD:275368	7/17 (41%)
		C2H2 Zn finger	678..698	CDD:275368	4/19 (21%)
		C2H2 Zn finger	706..726	CDD:275368	6/19 (32%)
		C2H2 Zn finger	734..754	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	1	0.960