DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and LOC110439308

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_021330454.1	Gene:	LOC110439308 / 110439308	-ID:	-	Length:	556	Species:	Danio rerio

Alignment Length:	551	Identity:	158/551 - (28%)
Similarity:	233/551 - (42%)	Gaps:	147/551 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 DNEDSQGEA--------PNLKLEPGTLELSPKTEL---QESMHFSETDATIK-------KERPYS 293
            :|::|:.|.        |||:.. |.|:...|..|   |....| .|..::|       :::|:.
Zfish    46 ENKESEEEERHVEAEKNPNLQTS-GVLKRRDKNRLTCTQCGKSF-RTKKSLKLHMRIHTRKKPFK 108

  Fly   294 CDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFT 358
            |.:|||||.....|..|.|:||||||..||.|||||.|...||.|:.:|:.|||:.|.:|:|||.
Zfish   109 CTQCGKSFQYSSSLNLHMRIHTGERPFTCTQCGKSFKHSSHLNQHMRIHTGERPFTCTQCEKSFQ 173

  Fly   359 LKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHS 423
            ...:|..|..:|:.||||.|.:||::|.....|..|...|..|:|:.|.:||:||..|..:|.|.
Zfish   174 YTSNLNKHMMIHTGERPFTCTQCGKSFRETSQLNKHMMIHTDEKPFTCTKCGKSFKHELSVIKHM 238

  Fly   424 RFHGSLNPFVCAECGASFPRKFQLVNHGRIH-GKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQA 487
            ..|....||:|::||.||.....|..|.|:| |:.|.:|..|||.|........| :.:||||:.
Zfish   239 MIHTGAKPFICSQCGKSFRLSSSLNQHMRVHTGEKPFTCPQCGKSFRYVSNFTKH-KMIHTGEKP 302

  Fly   488 HPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQAGQQTHPQTITVVSNP 552
            :.|..||:.|...:..::|:|| |.|..|:|.:               |.|        |..|.|
Zfish   303 YACSQCGKSFSHSSHRNRHMRT-HTGEKPHTCT---------------QCG--------TSFSEP 343

  Fly   553 GN-STLLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHF 616
            .: :..:.:.|.:     :| |.|.:||.:|:....|..|:::|||:|....:.|:.|      |
Zfish   344 SSLNQHMRIHTGE-----KP-FTCSQCGKSFSLSSRLTQHMKIHTGEKPHKCEHCSKT------F 396

  Fly   617 LSTASLNPGTVVTANPNLVGQSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVHGQ 681
            ||.:.|
Zfish   397 LSASQL----------------------------------------------------------- 402

  Fly   682 QQHLQHVAQQQQQQQQQQQQQQQHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHNRRHPNGGCT 746
            :.||                      ||..:.||.|  |..|.|.:..:..|.:|.:.|    ..
Zfish   403 KMHL----------------------SVHRSEKPYS--CPVCEKSYTVESKLKRHQKSH----TA 439

  Fly   747 VRTHVC-ECGKAFFQKNHLMLHQRQHLETKP 776
            ||.::| :|.|.:.....|.||:|.|...||
Zfish   440 VRQYMCFKCKKTYITATQLKLHERNHTGEKP 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	39/90 (43%)
		C2H2 Zn finger	294..314	CDD:275368	9/19 (47%)
		zf-H2C2_2	306..331	CDD:290200	16/24 (67%)
		C2H2 Zn finger	322..342	CDD:275368	11/19 (58%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		zf-H2C2_2	362..385	CDD:290200	10/22 (45%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		zf-H2C2_2	390..415	CDD:290200	10/24 (42%)
		C2H2 Zn finger	406..426	CDD:275368	8/19 (42%)
		SIR2	<425..>465	CDD:294129	15/40 (38%)
		C2H2 Zn finger	434..454	CDD:275368	8/19 (42%)
		C2H2 Zn finger	461..482	CDD:275368	6/20 (30%)
		C2H2 Zn finger	490..509	CDD:275368	5/18 (28%)
		lambda-1	491..>603	CDD:212564	28/112 (25%)
		C2H2 Zn finger	575..595	CDD:275368	6/19 (32%)
		C2H2 Zn finger	720..740	CDD:275368	5/19 (26%)
		C2H2 Zn finger	752..771	CDD:275368	7/19 (37%)
LOC110439308	XP_021330454.1	COG5048	81..450	CDD:227381	140/493 (28%)
		C2H2 Zn finger	81..101	CDD:275368	4/20 (20%)
		C2H2 Zn finger	109..129	CDD:275368	9/19 (47%)
		C2H2 Zn finger	137..157	CDD:275368	11/19 (58%)
		C2H2 Zn finger	165..185	CDD:275368	7/19 (37%)
		C2H2 Zn finger	193..213	CDD:275368	6/19 (32%)
		C2H2 Zn finger	221..241	CDD:275368	8/19 (42%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	6/20 (30%)
		C2H2 Zn finger	305..325	CDD:275368	7/20 (35%)
		C2H2 Zn finger	333..353	CDD:275368	5/42 (12%)
		C2H2 Zn finger	361..381	CDD:275368	6/19 (32%)
		C2H2 Zn finger	389..409	CDD:275368	9/106 (8%)
		SFP1	<412..491	CDD:227516	21/65 (32%)
		C2H2 Zn finger	417..437	CDD:275368	5/19 (26%)
		C2H2 Zn finger	445..465	CDD:275368	7/19 (37%)
		C2H2 Zn finger	473..493	CDD:275368
		C2H2 Zn finger	501..521	CDD:275368
		zf-H2C2_2	514..538	CDD:316026
		C2H2 Zn finger	529..549	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595222
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930