DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and si:ch211-261d7.6

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_017206987.1	Gene:	si:ch211-261d7.6 / 108179605	ZFINID:	ZDB-GENE-141216-266	Length:	1481	Species:	Danio rerio

Alignment Length:	1003	Identity:	182/1003 - (18%)
Similarity:	287/1003 - (28%)	Gaps:	432/1003 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 GQTVLTAGSA---------AAKSHFSSIGALHLTQEE-----CNEILIKRAIAAGHHQTHTITAA 203
            |:|..|.|..         |:||.|..|.  ||.::.     |.....:.:....|.:.|.:
Zfish   222 GKTYSTIGQCLNHERSHKQASKSVFHQIA--HLKKKSFQCPTCGRCYSRASALDAHRRCHEV--- 281

  Fly   204 DGSHHHASGGTPSFCSVGGATTLLGDILPGISVQVQKVIQGLEDNEDSQGEAPNLKLEPGTLELS 268
                                     .::...:.:.:|.   :..||.|..:..|     ||  .|
Zfish   282 -------------------------KLVKSKTFETEKT---MSLNEASAQDQNN-----GT--SS 311

  Fly   269 PKTELQESMHF----------------------SETDATIKKE--RPYSCDECGKSFLLKHHLTT 309
            .:||.||...|                      |.:|..:|:|  .|:.|.||||:|:....|..
Zfish   312 EQTEEQEQKVFQCFCGRSFRTMCGLGTHQRFSTSCSDGKVKEEIKHPFVCSECGKTFISSVALLC 376

  Fly   310 HARVH-------TGERPHICTHCGKSFAHKHCLNTH-LLLHSTE---------------RPYQCQ 351
            |.|.|       ...:.:.|:.||:.|......|.| .|.||.|               :.::||
Zfish   377 HQRWHKRREQLVCNNQSYKCSECGRVFTSLTFYNKHQRLAHSEEQAAKSFLHQVIQLKKKAFECQ 441

  Fly   352 ECKKSFT----LKHHLLTHSRV------------------------------------------- 369
            :|.:.|:    |:.|.|.|:..
Zfish   442 QCGRRFSRASALQSHQLCHTDAFFDIMEKKPEMSTAIHTVKIQEDHVDSVVFQAQDISDVQVQEK 506

  Fly   370 ----------------------------------------------------------------- 369

Zfish   507 DINCNNTVEEHNAVDADYEVVHITSSDDSESTQDPNPDLELVCESDQEEKDDLSLTAESTSSLPL 571

  Fly   370 --------------HSRERPFV----------------CQECGRAF----PLKRHLVTHSK---- 396
                          |..|.||:                |..|.|.|    .|:.|::.|.:
Zfish   572 NPAIDVKIVQIDYEHLNEEPFMNAELMSKSHPRVAKYNCPHCDRKFFKASSLRCHVLWHKRSMRK 636

  Fly   397 ----------------------------------FHAGERP-------------------YVCEE 408
                                              ||.|:..                   ..|||
Zfish   637 KAEWQKFDILSPTKKVLLTCEVCGHESPSKSAHYFHMGKHDDKVACKSISYQLENLQKNNIKCEE 701

  Fly   409 CGESFAQENHLIMHSRFH-GSLNPFVCAECGASFPRKFQLVNHGRIHGKIPHSCTVCG------- 465
            ||..|::.:.|..|.:.| |...||.|.:|..|:.....|.||.::       |  ||
Zfish   702 CGMCFSRLSALHSHQQLHSGKKKPFACLQCERSYATASGLYNHQKV-------C--CGGAKDEMT 757

  Fly   466 KEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAEL--HQHVRTAHNGVNPNTSSATIIANQQ 528
            |.|...:||:        |.:.|.|..||:||.:....  |:...:....|....:||....|..
Zfish   758 KHFNPTKTLL--------GPKVHHCKKCGKGFWSMGAFCHHKQNNSECADVETRPASAGATENGH 814

  Fly   529 LQQAHHHQAG--QQTHPQTITVVSN---PGNSTLLTVS------TTDANGVARP----------- 571
            :::....:.|  ::.||....|...   .|.|..:...      ..||.|: ||
Zfish   815 IRRKKRGRRGGYKKVHPMNSKVEHKCEVCGKSYHMLACFLKHKLVHDAQGL-RPAVKSFDYQVQQ 878

  Fly   572 ----QFVCRECGSAFNSREALALHLRLHTGDKSL-MTDLCALTAALPGHFLSTASLNPGTVVT-- 629
                .:.|.:||..|:...||..|::.|..:..| :||        ||     :|..|..:..
Zfish   879 LKKNSYQCPDCGKVFSRAMALQFHMKSHGFETGLPVTD--------PG-----SSERPQCLTCYS 930

  Fly   630 --ANPNLVGQSP----VPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQHV 688
              |:.:|:....    .|...:.|:.:.....|.:|.|:|...:.|....|: .|..::|.....
Zfish   931 FFASESLLQDHQKHCLKPEDNVESSQEHEKVGTEIQDASSQKSEDVSEMSPS-AVSDKEQKAPSA 994

  Fly   689 AQQQ----------------------QQQQQQQQQQQQHVVSVAPANKPKSH--------FCASC 723
            :..:                      .::..|.::.:.:.|.....:|.|:.        .||.|
Zfish   995 SNMKYKCKDCSRSFSVIGALNFHKRIHRKGHQSKKMKSYPVKPLKLSKVKAEKCSAKSPFVCAEC 1059

  Fly   724 GKGFAAKHGLMQHNRRHPNGGC--------TVRT--------HVCE-CGKAFFQKNHLMLHQRQH 771
            |:.|.....|..|.|.|.:...        |||:        ::|. |||.||....|..||..|
Zfish  1060 GRHFRTNSALGTHKRWHKDKKFAKYLSKTNTVRSRKSMDGGPYLCNLCGKGFFYLCVLRRHQLHH 1124

  Fly   772 --LETKPAISQQQEAATQQQLATAGEQQ 797
              :|.:|  .:..|.|..:.|.|..:.|
Zfish  1125 PPMEAQP--QKDNEVAESKDLYTCPDCQ 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	31/234 (13%)
		C2H2 Zn finger	294..314	CDD:275368	9/19 (47%)
		zf-H2C2_2	306..331	CDD:290200	8/31 (26%)
		C2H2 Zn finger	322..342	CDD:275368	7/20 (35%)
		C2H2 Zn finger	350..370	CDD:275368	8/145 (6%)
		zf-H2C2_2	362..385	CDD:290200	10/160 (6%)
		C2H2 Zn finger	378..398	CDD:275368	7/61 (11%)
		zf-H2C2_2	390..415	CDD:290200	11/81 (14%)
		C2H2 Zn finger	406..426	CDD:275368	8/19 (42%)
		SIR2	<425..>465	CDD:294129	11/40 (28%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		C2H2 Zn finger	461..482	CDD:275368	7/27 (26%)
		C2H2 Zn finger	490..509	CDD:275368	6/20 (30%)
		lambda-1	491..>603	CDD:212564	29/140 (21%)
		C2H2 Zn finger	575..595	CDD:275368	7/19 (37%)
		C2H2 Zn finger	720..740	CDD:275368	8/19 (42%)
		C2H2 Zn finger	752..771	CDD:275368	9/19 (47%)
si:ch211-261d7.6	XP_017206987.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100