DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and si:cabz01071911.3

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_001344835.4	Gene:	si:cabz01071911.3 / 103908660	ZFINID:	ZDB-GENE-161017-60	Length:	387	Species:	Danio rerio

Alignment Length:	424	Identity:	120/424 - (28%)
Similarity:	179/424 - (42%)	Gaps:	115/424 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 GISVQVQKVIQGLEDNEDSQGEAPNLK---LEPGTLELSPKTE-----LQESMH----------- 278
            |..:::.:|......:.:||.:...||   .|.|.:|||.:.:     :.:..|
Zfish    11 GEDLRLAEVFSLKHKDPESQTDPIPLKGERKEQGEMELSDQYKHLGFVINDKSHTVSHFASKESG 75

  Fly   279 --------FSETDATIKKERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCL 335
                    |.:....:..|:|::|.|||.|:..|.:|..|.|||:||:...|..||.::|.|..|
Zfish    76 KSFDNAGSFKDHLKLLSGEKPFTCQECGCSYTTKGNLKVHMRVHSGEKTFNCPVCGNAYARKGSL 140

  Fly   336 NTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRVHSRERPFVCQECGRAFP----LKRHLVTHSK 396
            :||:.:||.|:|:.|..|.|:::.|.:|..|.|:||.|:.|.||.||..:.    ||.|:..||:
Zfish   141 DTHMRVHSGEKPFSCPMCGKNYSTKGNLDAHIRIHSGEKTFNCQVCGNNYSTKGNLKSHMRIHSR 205

  Fly   397 F------------------------HAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAEC 437
            .                        |:|| .:.|:|||:|::.:.:|.:|.|.|....||.|.||
Zfish   206 GKTGAGCQCGTCSVCQANLALHNTPHSGE-SFTCQECGKSYSTKGNLKVHMRIHSGEKPFACQEC 269

  Fly   438 GASFPRKFQLVNHGRIH-GKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKA 501
            |.....|..|..|.||| |:.|.||.:||..|..|..|..|| |||:||:.:.||.||:.|..:.
Zfish   270 GRCCSTKGNLKVHMRIHSGEKPFSCVLCGSRFSTKGNLDVHM-RVHSGEKPYACVQCGKCFKCQG 333

  Fly   502 ELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTDAN 566
            .|..|: ..|.|..|
Zfish   334 NLSLHL-IIHTGEKP-------------------------------------------------- 347

  Fly   567 GVARPQFVCRECGSAFNSREALALHLRLHTGDKS 600
                  |.|.:||..||.:..|..|:.:|..:.|
Zfish   348 ------FTCPQCGKRFNKKGILKSHMNVHNKETS 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	34/83 (41%)
		C2H2 Zn finger	294..314	CDD:275368	9/19 (47%)
		zf-H2C2_2	306..331	CDD:290200	10/24 (42%)
		C2H2 Zn finger	322..342	CDD:275368	8/19 (42%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		zf-H2C2_2	362..385	CDD:290200	11/22 (50%)
		C2H2 Zn finger	378..398	CDD:275368	9/47 (19%)
		zf-H2C2_2	390..415	CDD:290200	11/48 (23%)
		C2H2 Zn finger	406..426	CDD:275368	8/19 (42%)
		SIR2	<425..>465	CDD:294129	17/40 (43%)
		C2H2 Zn finger	434..454	CDD:275368	8/19 (42%)
		C2H2 Zn finger	461..482	CDD:275368	9/20 (45%)
		C2H2 Zn finger	490..509	CDD:275368	7/18 (39%)
		lambda-1	491..>603	CDD:212564	19/110 (17%)
		C2H2 Zn finger	575..595	CDD:275368	7/19 (37%)
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
si:cabz01071911.3	XP_001344835.4	C2H2 Zn finger	75..91	CDD:275368	1/15 (7%)
		COG5048	95..>370	CDD:227381	104/333 (31%)
		C2H2 Zn finger	99..119	CDD:275368	9/19 (47%)
		zf-H2C2_2	111..136	CDD:290200	10/24 (42%)
		C2H2 Zn finger	127..147	CDD:275368	8/19 (42%)
		zf-H2C2_2	139..164	CDD:290200	10/24 (42%)
		C2H2 Zn finger	155..175	CDD:275368	7/19 (37%)
		C2H2 Zn finger	183..203	CDD:275368	7/19 (37%)
		zf-C2H2	236..258	CDD:278523	8/21 (38%)
		C2H2 Zn finger	238..258	CDD:275368	8/19 (42%)
		zf-H2C2_2	250..275	CDD:290200	10/24 (42%)
		C2H2 Zn finger	266..286	CDD:275368	8/19 (42%)
		zf-H2C2_2	278..303	CDD:290200	12/24 (50%)
		C2H2 Zn finger	294..314	CDD:275368	9/20 (45%)
		zf-H2C2_2	306..331	CDD:290200	13/25 (52%)
		C2H2 Zn finger	322..342	CDD:275368	7/20 (35%)
		zf-H2C2_2	334..358	CDD:290200	9/80 (11%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595234
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930