DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and si:ch1073-127d16.1

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_021323944.1	Gene:	si:ch1073-127d16.1 / 101883863	ZFINID:	ZDB-GENE-120214-30	Length:	454	Species:	Danio rerio

Alignment Length:	569	Identity:	167/569 - (29%)
Similarity:	243/569 - (42%)	Gaps:	165/569 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 ED--NEDSQG-----EAPNLKLEPGTLELSPKTELQ-ESMHFSETDA----------TIKK---- 288
            ||  :.|||.     |.|:||::.|.: .:|...|: ..::.||...          |:|:
Zfish     8 EDCVSHDSQSGPYFTEQPSLKIQTGDI-FTPIQSLESHKVNHSEKQTFICAECGKSFTLKRYLKN 71

  Fly   289 -------ERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTER 346
                   ..|::|.||.|.|.:||.|.||.::||||:|..|..|||.|..|..|:.||.:|:.|:
Zfish    72 HMKIHTGAHPFTCPECDKCFTMKHSLETHLKIHTGEKPFTCPDCGKKFRLKQSLDGHLRIHTGEK 136

  Fly   347 PYQCQECKKSFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGE 411
            ||.||.|.:||..|..|..|..:|:.|:|:.|.|||::|.:|..|..|.|.|.||:||.|:|||:
Zfish   137 PYTCQVCGRSFREKQILDKHLTIHTGEKPYSCPECGKSFRVKNCLENHIKIHTGEKPYTCQECGK 201

  Fly   412 SFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIH-GKIPHSCTVCGKEFLQKRTLV 475
            ||.::.:|..|.|.|....||.|.|||.||..|..|..|.||| |:.|.||..|||.|.:.:.|.
Zfish   202 SFTEKQNLERHIRIHTGEKPFACPECGRSFRVKQDLKIHLRIHTGEKPFSCQQCGKSFSENKKLE 266

  Fly   476 SHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQAGQQ 540
            :|| |:||||:...|..||:.|..|..|..|:| .|.|..|
Zfish   267 NHM-RIHTGEKPFVCSHCGKNFRGKQNLESHMR-LHTGNQP------------------------ 305

  Fly   541 THPQTITVVSNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDL 605
                                            :.|.:||.::|.:::|.:|:|.|||:|....|.
Zfish   306 --------------------------------YTCPQCGKSYNQQKSLQIHIRTHTGEKPFACDQ 338

  Fly   606 CALT----AALPGHF-LSTASLNPGTVVTANPNLVGQSPVPVQIISSTGQVMSQTTLVQAANSTH 665
            |..:    :.|.||. :.|                |:.|.                       |.
Zfish   339 CGKSFTQQSTLKGHIKIHT----------------GEKPF-----------------------TC 364

  Fly   666 PQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHVVSVAPANKPKSHFCASCGKGFAAK 730
            ||...:.:                    ::.:.::.::.|       :..|::.|..|.|.|..|
Zfish   365 PQCGKSFI--------------------EKTKLERHKKIH-------SGEKAYTCQHCKKSFTLK 402

  Fly   731 HGLMQHNRRHPNGGCTVRTHVC-ECGKAFFQKNHLMLHQRQHLETKPAI 778
            ..|..|.|.|..    .:.:.| :|||:|.:|..|:.|...|.|.|||:
Zfish   403 QSLDIHMRIHTG----EKLYTCQQCGKSFTEKQKLLSHMTVHTEEKPAL 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	38/94 (40%)
		C2H2 Zn finger	294..314	CDD:275368	10/19 (53%)
		zf-H2C2_2	306..331	CDD:290200	13/24 (54%)
		C2H2 Zn finger	322..342	CDD:275368	9/19 (47%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		zf-H2C2_2	362..385	CDD:290200	9/22 (41%)
		C2H2 Zn finger	378..398	CDD:275368	9/19 (47%)
		zf-H2C2_2	390..415	CDD:290200	14/24 (58%)
		C2H2 Zn finger	406..426	CDD:275368	9/19 (47%)
		SIR2	<425..>465	CDD:294129	19/40 (48%)
		C2H2 Zn finger	434..454	CDD:275368	10/19 (53%)
		C2H2 Zn finger	461..482	CDD:275368	9/20 (45%)
		C2H2 Zn finger	490..509	CDD:275368	7/18 (39%)
		lambda-1	491..>603	CDD:212564	21/111 (19%)
		C2H2 Zn finger	575..595	CDD:275368	7/19 (37%)
		C2H2 Zn finger	720..740	CDD:275368	8/19 (42%)
		C2H2 Zn finger	752..771	CDD:275368	8/19 (42%)
si:ch1073-127d16.1	XP_021323944.1	COG5048	36..445	CDD:227381	154/536 (29%)
		C2H2 Zn finger	56..76	CDD:275368	2/19 (11%)
		C2H2 Zn finger	84..104	CDD:275368	10/19 (53%)
		C2H2 Zn finger	112..132	CDD:275368	9/19 (47%)
		C2H2 Zn finger	140..160	CDD:275368	8/19 (42%)
		C2H2 Zn finger	168..188	CDD:275368	9/19 (47%)
		C2H2 Zn finger	196..216	CDD:275368	9/19 (47%)
		C2H2 Zn finger	224..244	CDD:275368	10/19 (53%)
		C2H2 Zn finger	252..272	CDD:275368	9/20 (45%)
		C2H2 Zn finger	280..300	CDD:275368	8/20 (40%)
		C2H2 Zn finger	308..328	CDD:275368	7/19 (37%)
		C2H2 Zn finger	336..356	CDD:275368	5/19 (26%)
		C2H2 Zn finger	364..384	CDD:275368	2/39 (5%)
		C2H2 Zn finger	392..412	CDD:275368	8/19 (42%)
		C2H2 Zn finger	420..440	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595224
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840