DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and Zfp513

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_006503720.3	Gene:	Zfp513 / 101023	MGIID:	2141255	Length:	582	Species:	Mus musculus

Alignment Length:	524	Identity:	110/524 - (20%)
Similarity:	157/524 - (29%)	Gaps:	190/524 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 NEILIKRAIAAG--HHQTHTITAADGSHHHASGGTPSFCSVGGATTLLGDILPGISVQVQK---- 240
            |..|:...:.:|  .|:......:..:...|.....||....||..|..|:|.|..::.::
Mouse    29 NHFLVMLRLRSGCTAHELRIPCCSAVAEAEAVDTEDSFDEGPGALVLESDLLLGQDLEFEEEEEE 93

  Fly   241 --------VIQGLE-DNE-DSQGEAPNLKL------EPGTLELSPKTELQESMHFSETDATIKKE 289
                    .:.|.| |:| ||||..|.|..      ..|...||.::|::|.   :......:.|
Mouse    94 DEGDGHNDQLMGFERDSEGDSQGARPGLPYGLSDDESGGGRALSAESEVEEP---ARGPGEARGE 155

  Fly   290 RP---------------------------------YSCDECGKSFLLKHHLTTHARVHTGERPHI 321
            ||                                 |||..|........||..|.:.|:||:|..
Mouse   156 RPGPACQLCGGPTGEGPCCGAGGPGGGPPLPPRLLYSCRLCAFVSHYSSHLKRHMQTHSGEKPFR 220

  Fly   322 CTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRVHS--------------- 371
            |..|..:.|....|..|...|:.|:||:|..|..:.:...:|..|.|.|:
Mouse   221 CGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFACSSLGNLRRHQRTHTGPPTPPCPTCGFRCC 285

  Fly   372 -------------------RER------------------------------------------- 374
                               |..
Mouse   286 APRPTRPPSPTEQEGTMPRRSEDALILPDLSLHVPPGGASFLPDCGQLRGEGESLCGTGSEPLPE 350

  Fly   375 ---PFVCQECGR----------------------------------------------AFPLKRH 390
               |:.|:.||:                                              |.....|
Mouse   351 LLFPWTCRGCGQELEEGEGSRLGAAMCGRCMRGEAGGVATGGPQGPGDKGFACSLCPFATHYPNH 415

  Fly   391 LVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIH- 454
            |..|.|.|:||:|:.|..|..:.|..::|..|.|.|....|:.|..|..:......|..|||||
Mouse   416 LARHMKTHSGEKPFRCARCPYASAHLDNLKRHQRVHTGEKPYKCPLCPYACGNLANLKRHGRIHS 480

  Fly   455 GKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCG--EGFLTKAELHQHVRTAHNGV-NP 516
            |..|..|::|.....|...|..||.| ||||:...|.:|.  .|.....:.||.|. .|.|. .|
Mouse   481 GDKPFRCSLCNYSCNQSMNLKRHMLR-HTGEKPFRCATCAYTTGHWDNYKRHQKVH-GHGGAGGP 543

  Fly   517 NTSS 520
            ..|:
Mouse   544 GLSA 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	28/116 (24%)
		C2H2 Zn finger	294..314	CDD:275368	5/19 (26%)
		zf-H2C2_2	306..331	CDD:290200	9/24 (38%)
		C2H2 Zn finger	322..342	CDD:275368	5/19 (26%)
		C2H2 Zn finger	350..370	CDD:275368	5/19 (26%)
		zf-H2C2_2	362..385	CDD:290200	9/148 (6%)
		C2H2 Zn finger	378..398	CDD:275368	8/65 (12%)
		zf-H2C2_2	390..415	CDD:290200	10/24 (42%)
		C2H2 Zn finger	406..426	CDD:275368	6/19 (32%)
		SIR2	<425..>465	CDD:294129	13/40 (33%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		C2H2 Zn finger	461..482	CDD:275368	7/20 (35%)
		C2H2 Zn finger	490..509	CDD:275368	6/20 (30%)
		lambda-1	491..>603	CDD:212564	9/33 (27%)
		C2H2 Zn finger	575..595	CDD:275368
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
Zfp513	XP_006503720.3	C2H2 Zn finger	193..213	CDD:275368	5/19 (26%)
		zf-H2C2_2	205..230	CDD:372612	9/24 (38%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		zf-H2C2_2	233..258	CDD:372612	8/24 (33%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	403..423	CDD:275368	5/19 (26%)
		COG5048	<413..>491	CDD:227381	27/77 (35%)
		C2H2 Zn finger	431..451	CDD:275368	6/19 (32%)
		COG5048	455..>528	CDD:227381	25/73 (34%)
		C2H2 Zn finger	459..479	CDD:275368	6/19 (32%)
		C2H2 Zn finger	487..507	CDD:275368	7/20 (35%)
		C2H2 Zn finger	515..534	CDD:275368	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100