DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and znf770

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_005160468.1	Gene:	znf770 / 100535231	ZFINID:	ZDB-GENE-030131-1505	Length:	1207	Species:	Danio rerio

Alignment Length:	854	Identity:	159/854 - (18%)
Similarity:	251/854 - (29%)	Gaps:	318/854 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 HHASGGTP-SFCSVGGATTLLGDILPGISVQVQKVIQGLE-DNEDSQGEAPNLKLEPGTLELSPK 270
            :..:..|| :|.....:....||:...:|...::.::.|: ||..:| .||.:.....||    |
Zfish   353 NEGNSSTPGAFDGSNNSRLNAGDVSQNLSTVDKQHLEMLQCDNHLNQ-NAPLINSSADTL----K 412

  Fly   271 TELQESM-------HFSETDATIKKERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKS 328
            .|:.|..       :|..|...:.:     |..|.|.|.....|:.|..|||.::|..|:.|.||
Zfish   413 EEVIEEQIADANPTYFKHTSKNVNQ-----CKICLKKFSYPSRLSRHLLVHTDDKPFKCSECSKS 472

  Fly   329 FAHKHCLNTHLLLHSTERP---------------------------YQCQECKKSFTLKHHLLTH 366
            |.:.:.|..|..:|..|:.                           |||..|.|:|::...|..|
Zfish   473 FRNPYHLRRHQKIHKREKKYIANKTGHQLLYSSNVTSTSLLKTDSGYQCDVCLKTFSVPSKLRRH 537

  Fly   367 SRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAG------------------------------- 400
            ..|||..:|:.|..|.::|.....|..|.|.|.|
Zfish   538 QIVHSGTKPYTCMICRKSFSQAYSLTKHIKLHTGKVNSPSLLHWLRGSKSSITGALQTNNCGPND 602

  Fly   401 --------------------------------------------------ERPYV---------- 405
                                                              |.|..
Zfish   603 ANASLPKELDSVDGQTNEKLQDHSQLDQNVSLTESSNTVKTESEDVLKDSEEPTANSSPTNSLDK 667

  Fly   406 ------CEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIHGKI------- 457
                  |..|.::|...:.|..|...|....||.|..|..||..:..|.:|.:.|.|.
Zfish   668 SNDENQCVICLKTFPYPSKLSRHLLTHTDFKPFQCTVCSKSFRNESNLQSHEKFHKKTGKKRISA 732

  Fly   458 ----PHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNT 518
                .:.|.:|.|:|.....|..|: .:|:|.:.:.|:.||:.|.....|.:|:: .|.|...|.
Zfish   733 YSGPVYQCEICLKKFNFPSRLKRHL-SIHSGAKPYSCMICGKSFRLPEYLSEHLK-IHKGKKRNH 795

  Fly   519 SSAT--IIANQQLQ------QAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTDANGVARPQFVC 575
            ||..  :...|.:.      |...:|:...:...:.|....||||:.: ...:.:.||.:    |
Zfish   796 SSRLHGVPQKQGMDDKGSDTQTDENQSQNLSDVSSDTETQTPGNSSPM-YPESRSGGVNQ----C 855

  Fly   576 RECGSAFNSREALALHLRLHTGDKSLMTDLC-------------------ALTAALPGHF----- 616
            ..|...|.:...|..||..|.....|..::|                   |....:.|:.
Zfish   856 VICLKIFPNHPLLFKHLLGHADFTPLKCNVCLKSFRYLCNLESHKKMHHKAAKEKIAGNSQQDCA 920

  Fly   617 ------------LSTASLNPGTVVTANPNLVGQ-------------------------------- 637
                        |...|...|..|..:||::..
Zfish   921 DSGKAVASKDQDLKMPSSQDGATVHQDPNMLADNASQKMSGNCSDSGGLTSNGTRFLGNVVPNSE 985

  Fly   638 ------------------------------------SPVPVQIISS-----------------TG 649
                                                |..|.:..||                 ||
Zfish   986 VITQSSKKTVLGLTHNTDISVPAEKKAFDIVPFGRVSDFPPKTDSSLQPCASNSRTEQTWAHHTG 1050

  Fly   650 QVMSQTTLVQAANSTH-PQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHVVSVAPAN 713
            .:..:.:.|.:....| |:   ::||.:.:|.|:....:::....:.|...|....|      .|
Zfish  1051 NIKEEVSFVDSDTIKHVPE---SSVPPVSLHTQKPDNSNLSNADVRGQLNFQDPSGH------CN 1106

  Fly   714 KPKSHF--CASCGKGFAAKHGLMQHNRRHPNGGCT--------VRTHVCE-CGKAFFQKNHLMLH 767
            ||:..|  |:.||:.|..:.....|.       ||        .:.|.|: |.|.|...:.|..|
Zfish  1107 KPQHDFLICSDCGQSFPTEQKFYAHK-------CTNLESTEKFKKFHQCDICFKVFNVPSKLKRH 1164

  Fly   768 QRQHLETKP 776
            ...|...||
Zfish  1165 IISHTGQKP 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	28/110 (25%)
		C2H2 Zn finger	294..314	CDD:275368	6/19 (32%)
		zf-H2C2_2	306..331	CDD:290200	11/24 (46%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	6/19 (32%)
		zf-H2C2_2	362..385	CDD:290200	8/22 (36%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		zf-H2C2_2	390..415	CDD:290200	10/121 (8%)
		C2H2 Zn finger	406..426	CDD:275368	5/19 (26%)
		SIR2	<425..>465	CDD:294129	12/50 (24%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		C2H2 Zn finger	461..482	CDD:275368	6/20 (30%)
		C2H2 Zn finger	490..509	CDD:275368	6/18 (33%)
		lambda-1	491..>603	CDD:212564	28/119 (24%)
		C2H2 Zn finger	575..595	CDD:275368	6/19 (32%)
		C2H2 Zn finger	720..740	CDD:275368	5/19 (26%)
		C2H2 Zn finger	752..771	CDD:275368	6/19 (32%)
znf770	XP_005160468.1	C2H2 Zn finger	75..95	CDD:275368
		C2H2 Zn finger	103..123	CDD:275368
		C2H2 Zn finger	189..209	CDD:275368
		zf-H2C2_2	202..225	CDD:290200
		C2H2 Zn finger	217..257	CDD:275368
		C2H2 Zn finger	288..308	CDD:275368
		C2H2 Zn finger	316..336	CDD:275368
		C2H2 Zn finger	438..458	CDD:275368	6/19 (32%)
		zf-C2H2	464..486	CDD:278523	7/21 (33%)
		C2H2 Zn finger	466..486	CDD:275368	7/19 (37%)
		COG5048	497..902	CDD:227381	76/411 (18%)
		C2H2 Zn finger	521..541	CDD:275368	6/19 (32%)
		zf-H2C2_2	534..558	CDD:290200	9/23 (39%)
		C2H2 Zn finger	549..569	CDD:275368	6/19 (32%)
		C2H2 Zn finger	674..694	CDD:275368	5/19 (26%)
		C2H2 Zn finger	702..722	CDD:275368	6/19 (32%)
		C2H2 Zn finger	740..760	CDD:275368	6/20 (30%)
		C2H2 Zn finger	768..788	CDD:275368	6/20 (30%)
		C2H2 Zn finger	855..875	CDD:275368	6/19 (32%)
		C2H2 Zn finger	883..903	CDD:275368	1/19 (5%)
		C2H2 Zn finger	1115..1135	CDD:275368	6/26 (23%)
		C2H2 Zn finger	1148..1168	CDD:275368	6/19 (32%)
		zf-H2C2_2	1161..1185	CDD:290200	5/13 (38%)
		C2H2 Zn finger	1176..1196	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100