DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and si:cabz01032454.3

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_003198589.1	Gene:	si:cabz01032454.3 / 100534979	ZFINID:	ZDB-GENE-161017-73	Length:	499	Species:	Danio rerio

Alignment Length:	611	Identity:	180/611 - (29%)
Similarity:	243/611 - (39%)	Gaps:	165/611 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 EECNEILIKRAIAAGHHQTH-TITAADGSHHHASGGTPS--FCSVGGATTLLGDILPGISVQVQK 240
            :|.||:..|..|     :|| .:|..:.|....|..|.|  .||..|         .|.:.|...
Zfish    37 QEMNEMKEKDQI-----ETHQDLTTDEQSSCKRSPKTKSDFICSQCG---------KGFNHQPNL 87

  Fly   241 VIQGLEDNEDSQGEAPNLKLEPG-TLELSPKTELQESMHFSETDATIKKERPYSCDECGKSFLLK 304
            ::.    .....||.|....:.| :...:.|.::...:|        .|||||:|.:|||||..|
Zfish    88 IVH----MRIHTGERPYSCDQCGKSFSQNEKLKVHMRVH--------TKERPYTCPQCGKSFTQK 140

  Fly   305 HHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRV 369
            ..|..|.||||||:|..|.||||.|:..|.|..|:.:|:.|||:.|..|.|:|..|..|..|..|
Zfish   141 ESLNVHIRVHTGEKPFPCQHCGKRFSQLHALKEHVTIHTGERPHACTVCGKTFYHKQKLEKHMTV 205

  Fly   370 HSRERPFVCQECGRAF----PLKRHLVTHSKF--HAGERPYVCEECGESFAQENHLIMHSRFHGS 428
            |:.|:.|.||:||:.|    .|:.|:..|:|.  ||.|:||:|.||.::||.:::|..|...|..
Zfish   206 HTGEKLFDCQQCGKRFGQKDSLRIHMKLHTKDKPHAKEKPYICTECDKAFASKSNLNHHMVTHTG 270

  Fly   429 LNPFVCAECGASFPRKFQLVNHGRIHGK-IPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVS 492
            ..||.|.|||.||.:..:|..|.|:|.| .|:||..|||.|.|...|..|| ||||.|:.:.|..
Zfish   271 EKPFSCDECGKSFGQNSKLKVHMRVHTKEKPYSCDQCGKSFSQNEKLKVHM-RVHTKERPYTCPQ 334

  Fly   493 CGEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQAGQQTHPQTITVVSNPGNSTL 557
            ||:.|..|..|..|:| .|.|..|
Zfish   335 CGKSFTQKENLKVHIR-VHTGEKP----------------------------------------- 357

  Fly   558 LTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHFLSTASL 622
                           |.|:|||..|.....|..|||.|||:|......|
Zfish   358 ---------------FPCQECGKRFMQLHVLKEHLRTHTGEKPFACPQC---------------- 391

  Fly   623 NPGTVVTANPNLVGQSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQH 687
                                          |:|...:.....|          |.||.:::...
Zfish   392 ------------------------------SKTYCQKQKLKMH----------MTVHAKEKLFP- 415

  Fly   688 VAQQQQQQQQQQQQQQQHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHNRRH---PNGGCTVRT 749
             .||..::...:...:.|:...|   :.|.|.|:.||:||..|..|..|.|.|   |:..||
Zfish   416 -CQQCGKRFGYRGSLKSHMKLHA---EDKRHTCSQCGEGFTMKSHLNSHMRTHSGEPSYSCT--- 473

  Fly   750 HVCECGKAFFQKNHLMLHQRQHLETK 775
               :|||.|.:|..|..|.|.|...|
Zfish   474 ---QCGKTFSRKYVLNCHMRTHTGEK 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	42/83 (51%)
		C2H2 Zn finger	294..314	CDD:275368	10/19 (53%)
		zf-H2C2_2	306..331	CDD:290200	15/24 (63%)
		C2H2 Zn finger	322..342	CDD:275368	9/19 (47%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		zf-H2C2_2	362..385	CDD:290200	10/22 (45%)
		C2H2 Zn finger	378..398	CDD:275368	9/25 (36%)
		zf-H2C2_2	390..415	CDD:290200	12/26 (46%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		SIR2	<425..>465	CDD:294129	17/40 (43%)
		C2H2 Zn finger	434..454	CDD:275368	9/19 (47%)
		C2H2 Zn finger	461..482	CDD:275368	10/20 (50%)
		C2H2 Zn finger	490..509	CDD:275368	7/18 (39%)
		lambda-1	491..>603	CDD:212564	24/111 (22%)
		C2H2 Zn finger	575..595	CDD:275368	9/19 (47%)
		C2H2 Zn finger	720..740	CDD:275368	9/19 (47%)
		C2H2 Zn finger	752..771	CDD:275368	8/18 (44%)
si:cabz01032454.3	XP_003198589.1	COG5048	52..481	CDD:227381	167/574 (29%)
		C2H2 Zn finger	74..94	CDD:275368	5/32 (16%)
		zf-H2C2_2	86..111	CDD:290200	4/28 (14%)
		C2H2 Zn finger	102..122	CDD:275368	2/19 (11%)
		zf-H2C2_2	115..139	CDD:290200	12/31 (39%)
		C2H2 Zn finger	130..150	CDD:275368	10/19 (53%)
		zf-H2C2_2	142..167	CDD:290200	15/24 (63%)
		C2H2 Zn finger	158..178	CDD:275368	9/19 (47%)
		C2H2 Zn finger	186..206	CDD:275368	7/19 (37%)
		C2H2 Zn finger	214..234	CDD:275368	7/19 (37%)
		C2H2 Zn finger	248..268	CDD:275368	7/19 (37%)
		zf-H2C2_2	260..283	CDD:290200	9/22 (41%)
		C2H2 Zn finger	276..296	CDD:275368	9/19 (47%)
		zf-H2C2_2	289..313	CDD:290200	12/23 (52%)
		C2H2 Zn finger	304..324	CDD:275368	10/20 (50%)
		zf-H2C2_2	317..341	CDD:290200	12/24 (50%)
		C2H2 Zn finger	332..352	CDD:275368	8/20 (40%)
		zf-H2C2_2	344..367	CDD:290200	11/79 (14%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	388..408	CDD:275368	5/75 (7%)
		C2H2 Zn finger	416..436	CDD:275368	3/19 (16%)
		C2H2 Zn finger	444..464	CDD:275368	9/19 (47%)
		C2H2 Zn finger	472..492	CDD:275368	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595229
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930