DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and patz1

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_004910653.1	Gene:	patz1 / 100494086	XenbaseID:	XB-GENE-976137	Length:	700	Species:	Xenopus tropicalis

Alignment Length:	667	Identity:	164/667 - (24%)
Similarity:	262/667 - (39%)	Gaps:	134/667 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 VVNDPSFPPGTQRVITAGGASTVVKKQDNNQQVLSLDKNYLLVDPATAAAAAAAAGGDSGLAHHH 140
            |:...|||    .::||.....:....|..|:|:......:||.||........:|. |.:....
Frog   102 VIRLESFP----ELMTAAKFLLMRSVIDICQEVIKQSNVQILVPPARPDIMLFRSGA-SDIGFPL 161

  Fly   141 TLTNGSIVDAKTGQTVLTAGSAAAKSHFSSIGALHLTQEECNEILIKRAIAA--------GHHQ- 196
            .::||:::.:..     .|||              |.:|:.:.:...:|:.:        |..|
Frog   162 DMSNGTVLGSSG-----IAGS--------------LGEEDEDSVRPGQAVPSQASLLALGGSPQI 207

  Fly   197 ---THTITAAD--GSHHHASGGTPS------FCSVGGATTLLGDILP-GISVQVQKVIQGLEDNE 249
               |:.:.:::  |.........||      ..:|||...  |.:|| |:..:|......|..:|
Frog   208 LPPTYQLGSSNLGGKRGRGRPRKPSVLDSVLLSAVGGLRE--GGVLPCGLCDKVFTDPLRLRHHE 270

  Fly   250 DSQGEAPNLKLEPGTLELSPKTEL---QESMHFSETDATIKKERPYSCDECGKSFLLKHHLTTHA 311
            ...| ..:|:|..|.|:.|..:|.   ||..........::|:  .|||.|||.|...:||..|.
Frog   271 AQHG-VTSLQLGYGDLQASRMSENGLGQEEPGIPRKRNRVRKQ--VSCDLCGKIFRDVYHLNRHK 332

  Fly   312 RVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRVHSRERPF 376
            ..|:||:|:.|..||..|..|..::.|:..|.                          .|..:|:
Frog   333 LSHSGEKPYSCPVCGLRFKRKDRMSYHVRSHD--------------------------GSVGKPY 371

  Fly   377 VCQECGRAFPLKRHLVTHSK-FHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGAS 440
            :||.||:.|....||..|.| .|..|||:.||:..|..:.|        ....|.......|.||
Frog   372 ICQSCGKGFSRPDHLNGHIKQVHTSERPHKCEKTTEGMSNE--------VRNELEKGGGQTCNAS 428

  Fly   441 FPRKFQLVNHGRIH-GKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELH 504
            |..:.:|.:|...| .|:|  |.|||| :|:...:|.|::: |:...::.|..|..||.:.:.|.
Frog   429 FATRDRLRSHLACHEDKVP--CQVCGK-YLRAAYMVDHLKK-HSEGPSNFCSICNRGFSSASYLK 489

  Fly   505 QHVRTAHNGV----------NPNTSS----ATIIANQQLQQAHHHQAGQQTHPQTITVVSNPGNS 555
            .||:|.|.|:          .||.::    ......::..:.||   |:|....:...:|.  :|
Frog   490 VHVKTHHGGLLSTGPRRQESVPNGAALFHCVRTCGVKEGDKCHH---GEQESSDSYGDLSE--SS 549

  Fly   556 TLLTVSTTDANG---------------VARPQFVCRECGSAFNSREALALHL-RLHTGD-KSLMT 603
            .|.:....:|||               .:..::.|.||||.|.|:..|:.|: ::||.. .:::.
Frog   550 DLKSTEKQNANGSYTACDLVIPKKTEAESEKRYPCIECGSFFRSKAYLSKHIQKVHTRPLGAVLG 614

  Fly   604 DLCALTAALPGHFLSTASLNPGTVVTANPNLVGQSPVPVQIISSTGQVMSQTTLVQAANSTHPQA 668
            ||........|..|. .||.|....|..|.| |.|..|. :.|:.....|....:....|...|.
Frog   615 DLGPALGPTLGPTLG-PSLGPALGPTLGPAL-GASLGPA-LGSALASPFSPQQNMSLLESFGFQI 676

  Fly   669 VVTAVPTMPV--HGQQQ 683
            |.:|..:..|  .|:||
Frog   677 VQSAFASSLVDPEGEQQ 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	22/83 (27%)
		C2H2 Zn finger	294..314	CDD:275368	9/19 (47%)
		zf-H2C2_2	306..331	CDD:290200	11/24 (46%)
		C2H2 Zn finger	322..342	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368	0/19 (0%)
		zf-H2C2_2	362..385	CDD:290200	6/22 (27%)
		C2H2 Zn finger	378..398	CDD:275368	9/20 (45%)
		zf-H2C2_2	390..415	CDD:290200	11/25 (44%)
		C2H2 Zn finger	406..426	CDD:275368	4/19 (21%)
		SIR2	<425..>465	CDD:294129	12/40 (30%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		C2H2 Zn finger	461..482	CDD:275368	8/20 (40%)
		C2H2 Zn finger	490..509	CDD:275368	7/18 (39%)
		lambda-1	491..>603	CDD:212564	32/142 (23%)
		C2H2 Zn finger	575..595	CDD:275368	9/20 (45%)
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
patz1	XP_004910653.1	BTB_POZ_ZBTB19_PATZ1	12..137	CDD:349516	9/38 (24%)
		C2H2 Zn finger	253..273	CDD:275368	4/19 (21%)
		C2H2 Zn finger	315..335	CDD:275368	9/19 (47%)
		COG5048	<327..496	CDD:227381	60/206 (29%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		C2H2 Zn finger	373..391	CDD:275368	8/17 (47%)
		C2H2 Zn finger	402..442	CDD:275368	11/47 (23%)
		C2H2 Zn finger	450..467	CDD:275368	7/18 (39%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-C2H2_assoc3	514..581	CDD:374693	10/71 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100