DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and zgc:171220

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001103300.1	Gene:	zgc:171220 / 100126101	ZFINID:	ZDB-GENE-071004-11	Length:	517	Species:	Danio rerio

Alignment Length:	615	Identity:	157/615 - (25%)
Similarity:	241/615 - (39%)	Gaps:	168/615 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 QVQKVIQGLEDNEDSQ----------GEAPNLKLEPGTLELSPKTELQESMHFSETDATIKKERP 291
            :.:::|...|.|||.|          ||.|.:|.||..               .:.|.||..:..
Zfish    14 ETEELIDQTEVNEDKQNLFNNPEGFSGENPQIKTEPNA---------------KKQDRTIGAKGS 63

  Fly   292 YSCDECGKSFLLKHHLTTHA-RVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKK 355
            ::|.||||.|.::..|..|. .||.||....|:.|||||.::..|:.||..|:..|.:.|.||.|
Zfish    64 FTCSECGKVFRIESWLKRHTLMVHNGETLLTCSPCGKSFINEAKLDKHLKSHTRNRSFTCTECGK 128

  Fly   356 SFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLI 420
            .|..:..|..|.|:|.:||||.|..||::|..:.:|..|.:.:...:|..|::|.::|...:.|.
Zfish   129 IFKSEDKLNNHVRIHDKERPFSCSVCGKSFKTEHNLSQHQRVYCDVKPLSCDQCHKTFLSRSLLK 193

  Fly   421 MHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIHGKI-PHSCTVCGKEFLQKRTLVSHMRRVHTG 484
            :|...|....|:||:.||.||....:|..|.|.|.:: ||.|::.||.||....|..| ..:|:|
Zfish   194 LHLVVHSGERPYVCSLCGKSFLYLNRLNAHERNHAEVKPHVCSLRGKSFLYMNRLKEH-ELIHSG 257

  Fly   485 EQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQAGQQTHPQTITVV 549
            .::|.|..||:.|.||..|.:| ::.|..|||
Zfish   258 VRSHVCPHCGKSFSTKRNLKKH-QSVHVEVNP--------------------------------- 288

  Fly   550 SNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAALPG 614
                                   |.|..||..|.::.::..||..|.|.||...|.|..:
Zfish   289 -----------------------FSCTHCGKTFRNKRSVQNHLIAHAGVKSFSCDQCDKS----- 325

  Fly   615 HFLSTASLNPGTVVTANPNLVGQSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVH 679
             |:..:.||....|.|     |..|   .:.|:.|:..|   ::|..
Zfish   326 -FIRASYLNRHLKVHA-----GLKP---HVCSTCGRSFS---ILQCL------------------ 360

  Fly   680 GQQQHLQHVAQQQQQQQQQQQQQQQHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHNRRHPNGG 744
             ::..|.|..:                         :.|.|:.|||.|...:.|.:|.|.|..
Zfish   361 -KRHQLVHTGE-------------------------RPHSCSDCGKSFRTSNYLRKHQRIHTG-- 397

  Fly   745 CTVRTHVC-ECGKAFFQKNHLMLHQRQHLETKP--------------AISQQQEA-ATQQQLATA 793
              .:.:.| :|||:|....:|.||||.|...||              .:|:..:| |..:..:..
Zfish   398 --EKPYSCAQCGKSFRCTKNLKLHQRSHSGEKPFSCDQCHKTFACPSNLSKHLKAHAAGRVCSDC 460

  Fly   794 GEQQQVQVQIMPDGQIH--GKVIKYEICRN 821
            |:..:...::....:||  .|..:..:|.|
Zfish   461 GQSFRTSAELKTHQRIHTGEKPYQCSLCGN 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	31/84 (37%)
		C2H2 Zn finger	294..314	CDD:275368	8/20 (40%)
		zf-H2C2_2	306..331	CDD:290200	12/25 (48%)
		C2H2 Zn finger	322..342	CDD:275368	9/19 (47%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		zf-H2C2_2	362..385	CDD:290200	11/22 (50%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		zf-H2C2_2	390..415	CDD:290200	6/24 (25%)
		C2H2 Zn finger	406..426	CDD:275368	5/19 (26%)
		SIR2	<425..>465	CDD:294129	15/40 (38%)
		C2H2 Zn finger	434..454	CDD:275368	8/19 (42%)
		C2H2 Zn finger	461..482	CDD:275368	7/20 (35%)
		C2H2 Zn finger	490..509	CDD:275368	8/18 (44%)
		lambda-1	491..>603	CDD:212564	22/111 (20%)
		C2H2 Zn finger	575..595	CDD:275368	6/19 (32%)
		C2H2 Zn finger	720..740	CDD:275368	8/19 (42%)
		C2H2 Zn finger	752..771	CDD:275368	10/19 (53%)
zgc:171220	NP_001103300.1	C2H2 Zn finger	66..87	CDD:275368	8/20 (40%)
		C2H2 Zn finger	95..115	CDD:275368	9/19 (47%)
		COG5048	118..489	CDD:227381	118/493 (24%)
		C2H2 Zn finger	123..143	CDD:275368	8/19 (42%)
		C2H2 Zn finger	151..170	CDD:275368	6/18 (33%)
		C2H2 Zn finger	179..199	CDD:275368	5/19 (26%)
		C2H2 Zn finger	207..227	CDD:275368	8/19 (42%)
		C2H2 Zn finger	235..255	CDD:275368	7/20 (35%)
		zf-C2H2	261..283	CDD:278523	9/22 (41%)
		C2H2 Zn finger	263..283	CDD:275368	8/20 (40%)
		C2H2 Zn finger	291..311	CDD:275368	6/19 (32%)
		C2H2 Zn finger	319..339	CDD:275368	5/25 (20%)
		C2H2 Zn finger	347..367	CDD:275368	5/41 (12%)
		zf-H2C2_2	360..384	CDD:290200	8/67 (12%)
		C2H2 Zn finger	375..395	CDD:275368	8/19 (42%)
		zf-H2C2_2	387..412	CDD:290200	9/28 (32%)
		C2H2 Zn finger	403..423	CDD:275368	10/19 (53%)
		zf-H2C2_2	415..440	CDD:290200	8/24 (33%)
		C2H2 Zn finger	431..451	CDD:275368	1/19 (5%)
		C2H2 Zn finger	485..505	CDD:275368	2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595230
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930