DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and znf711

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001161471.2	Gene:	znf711 / 100124306	XenbaseID:	XB-GENE-956382	Length:	807	Species:	Xenopus tropicalis

Alignment Length:	783	Identity:	155/783 - (19%)
Similarity:	246/783 - (31%)	Gaps:	289/783 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 ITAGGASTVVKKQDNNQQVLSLDKNYLLVDPATAAAAAAAAGGDSGLAHHHTLTNGSIVDAKTGQ 154
            |.|.|:|..:|.:|:  ::.:..::||::           :..|.|....|..:....:..:..|
Frog   176 IQAPGSSVTIKTEDD--EIKNTSEDYLMI-----------SLDDVGEKLEHIGSTPLKISTEVSQ 227

  Fly   155 TVLTAGSAAAKSHFSSIGALHLTQEECNEILIKRAIAAGHHQ---THTITAADGSHHHASGGTPS 216
                 |..:.:..|.|         |..::.|.:|.|....:   |..:|.:|..:.|...|...
Frog   228 -----GDMSKEDGFGS---------EVIKVYIFKAEAEDDVEIGGTEIVTESDFHNGHPVAGVIE 278

  Fly   217 FCSVG----------------------GATTLLGDILPGISVQVQKVIQGLED--------NEDS 251
            ..|:|                      |...:..::       ..:||.|.|:        ||||
Frog   279 QSSLGRMQREKMVYMAVKDSSQEDEEIGCAEIADEV-------YMEVIVGEEEAASLPDAQNEDS 336

  Fly   252 Q--------------GEAPNLKLEPGTLELSPKTELQESMHFSETDAT----------------- 285
            .              ||..:|..:.|..:.| ...::..:....:.||
Frog   337 SINKTFVPVAWAAAYGEDRDLPRKYGDWQES-ANNIESRLENKNSSATQYLQICDSIAANRALKQ 400

  Fly   286 -IKKER---------------------PYSCDECGKSF----LLKHHLTTHARVHTGERPHICTH 324
             .||.:                     .|.|..|||.|    .||.|:..|.. |..::.:.||.
Frog   401 KAKKRKRGDARQWQTAVIIGPDGQPLTVYPCHICGKKFKSRGFLKRHMKNHPD-HMIKKKYQCTD 464

  Fly   325 CG-----KSFAHKHCLNTHLLLHSTERPYQ------------------------------CQEC- 353
            |.     |...|.| |.:|.|.:..::.::                              |:.|
Frog   465 CDFTTNKKVSFHNH-LESHKLSNKVDKSHEFTEYTRRYREASPLSSNKLILRDKEPKLHKCKYCD 528

  Fly   354 ---KKSFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQ 415
               .:...|..|||.   |||:..|.||.|||:.|.....|..|.:.|.||:||:|..|....|.
Frog   529 YETAEQGLLNRHLLA---VHSKNFPHVCVECGKGFRHPSELKKHMRTHTGEKPYLCHFCEFRCAD 590

  Fly   416 ENHLIMH--SRFHGSLNPFVCAECGASFPRKFQLVNHGRI-HGKIPHSCTVCGKEFLQKRTLVSH 477
            :::|..|  || ||:..||.|.:|..:|..:.:|:.|..: .|...|.|..|..:......|..|
Frog   591 QSNLKTHIKSR-HGTDLPFKCEQCPQAFTDEKELLRHTELFQGHKTHQCPHCDHKSTNSSDLKRH 654

  Fly   478 MRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQAGQQTH 542
            :..|||.:..|.|..|.:||...:|:.:|..| |.|             :::.|..|  ...:|.
Frog   655 IISVHTKDFPHKCDVCDKGFHRPSEMKKHSET-HKG-------------KKIHQCRH--CDFKTS 703

  Fly   543 PQTITVVSNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCA 607
            ...|.      :..:|:|.|.|.      .|.|::|...|..:..|..|::.|:|.|......|.
Frog   704 DPFIL------SGHILSVHTKDL------PFKCKKCKRGFRIQPELKKHMKTHSGKKVYQCQYCE 756

  Fly   608 LTAALPGHFLSTASLNPGTVVTANPNLVGQSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTA 672
            .:......|
Frog   757 YSTTDASGF-------------------------------------------------------- 765

  Fly   673 VPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHN 737
                                          ::||:|:...:.|  |.|..|.|||.......||.
Frog   766 ------------------------------KRHVISIHTKDYP--HRCEFCKKGFRRPSEKNQHI 798

  Fly   738 RRH 740
            .||
Frog   799 MRH 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	29/147 (20%)
		C2H2 Zn finger	294..314	CDD:275368	9/23 (39%)
		zf-H2C2_2	306..331	CDD:290200	7/29 (24%)
		C2H2 Zn finger	322..342	CDD:275368	9/24 (38%)
		C2H2 Zn finger	350..370	CDD:275368	6/23 (26%)
		zf-H2C2_2	362..385	CDD:290200	12/22 (55%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		zf-H2C2_2	390..415	CDD:290200	9/24 (38%)
		C2H2 Zn finger	406..426	CDD:275368	7/21 (33%)
		SIR2	<425..>465	CDD:294129	12/40 (30%)
		C2H2 Zn finger	434..454	CDD:275368	5/20 (25%)
		C2H2 Zn finger	461..482	CDD:275368	4/20 (20%)
		C2H2 Zn finger	490..509	CDD:275368	6/18 (33%)
		lambda-1	491..>603	CDD:212564	25/111 (23%)
		C2H2 Zn finger	575..595	CDD:275368	5/19 (26%)
		C2H2 Zn finger	720..740	CDD:275368	7/19 (37%)
		C2H2 Zn finger	752..771	CDD:275368
znf711	NP_001161471.2	Zfx_Zfy_act	65..414	CDD:368066	44/272 (16%)
		COG5048	<422..600	CDD:227381	48/182 (26%)
		C2H2 Zn finger	431..451	CDD:275368	8/19 (42%)
		C2H2 Zn finger	524..545	CDD:275368	6/23 (26%)
		zf-C2H2	551..573	CDD:333835	8/21 (38%)
		C2H2 Zn finger	553..573	CDD:275368	7/19 (37%)
		zf-H2C2_2	565..589	CDD:372612	9/23 (39%)
		C2H2 Zn finger	581..602	CDD:275368	7/21 (33%)
		COG5048	<587..768	CDD:227381	52/295 (18%)
		C2H2 Zn finger	610..626	CDD:275368	4/15 (27%)
		C2H2 Zn finger	638..659	CDD:275368	4/20 (20%)
		C2H2 Zn finger	667..687	CDD:275368	7/20 (35%)
		C2H2 Zn finger	724..744	CDD:275368	5/19 (26%)
		C2H2 Zn finger	752..773	CDD:275368	5/106 (5%)
		C2H2 Zn finger	781..801	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100