DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and si:ch211-222k6.1

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_021324960.1	Gene:	si:ch211-222k6.1 / 100034531	ZFINID:	ZDB-GENE-050208-649	Length:	674	Species:	Danio rerio

Alignment Length:	587	Identity:	169/587 - (28%)
Similarity:	239/587 - (40%)	Gaps:	147/587 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 KTELQESMHFSETDATIKKERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHC 334
            ||.|.|.|.....|..      |:||:||||||||..|..|.::||||:|..|..|||:|.||..
Zfish    98 KTNLNEHMKIHNVDML------YTCDQCGKSFLLKERLNKHLKIHTGEKPFTCDQCGKNFLHKGY 156

  Fly   335 LNTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHA 399
            |..|:.:|:.|:|:.|.:|.|.|..|.:|..|.:||:.|||:.|.:|.:.|..|.:|:.|.|.|.
Zfish   157 LTEHIKIHTGEKPHTCDQCGKRFAYKGNLTDHMKVHTGERPYACDQCAKRFKHKGNLIEHVKIHT 221

  Fly   400 GERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIH---------- 454
            |||||.|::||:.|..::.|..|.|.|....||.|.:||.|:.||..|.:|.:.|
Zfish   222 GERPYSCDQCGKKFKLKHILSDHMRIHTGEKPFTCEKCGRSYTRKRNLSDHMKSHTGVKLHTCDQ 286

  Fly   455 -GKI------------------PHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTK 500
             ||.                  |.:|..|||:||:..||..|.:| |:|.:.|.|..||:.|...
Zfish   287 CGKSFVKTGVFKVHLRTHSRERPFNCDQCGKDFLRMGTLKVHQKR-HSGIKDHICSECGKTFFRD 350

  Fly   501 AEL--HQHVRTA-------------------------HNGVNPNTSSATIIANQQLQQAHHHQAG 538
            :||  ||.|.|.                         |.|..|...       ::..:...|:..
Zfish   351 SELKVHQSVHTGEKPFKCSHCEKTFKRAEYMKMHRKIHTGEKPYEC-------EKCGKKFRHKGN 408

  Fly   539 QQTHPQTITVVSNPGNSTLLTVSTTDANGVA---RPQF-------------VCRECGSAFNSREA 587
            ...|.:         |.|.:...:.|..|..   :..|             .|.:||..|..:..
Zfish   409 FNDHVK---------NHTRIKPFSCDQCGKCFRLKDNFDDHMKVHTGGNPHTCAQCGKTFKQKHV 464

  Fly   588 LALHLRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTVVTANPNLVGQSPVPVQIISSTGQVM 652
            |..||.:|||:|....:.|                  ||..|...||.....:      .||:.:
Zfish   465 LNEHLIIHTGEKPFTCEQC------------------GTSFTRKRNLADHMTI------HTGENL 505

  Fly   653 SQTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQ-HVAQQQQQQQQ------QQQQQQQHVVSVA 710
            ....  |...|.....|:           ::||: |.:::.....|      :....::| ::|.
Zfish   506 YACD--QCGRSFRQSRVL-----------KEHLRTHSSERPFNCDQCGKKFFKADALKEH-LTVH 556

  Fly   711 PANKPKSHFCASCGKGFAAKHGLMQHNRRHPNGGCTVRTHVC-ECGKAFFQKNHLMLHQRQHLET 774
            ...||  :.|:.|.|.|.....|..|.:.|..    .|.|:| ||||.||..:.|.||.|.|...
Zfish   557 TQEKP--YVCSFCAKAFRLIGNLKIHEKTHTG----QRNHICSECGKTFFTVSALTLHTRVHTVG 615

  Fly   775 KP 776
            ||
Zfish   616 KP 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	38/83 (46%)
		C2H2 Zn finger	294..314	CDD:275368	12/19 (63%)
		zf-H2C2_2	306..331	CDD:290200	12/24 (50%)
		C2H2 Zn finger	322..342	CDD:275368	9/19 (47%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		zf-H2C2_2	362..385	CDD:290200	9/22 (41%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		zf-H2C2_2	390..415	CDD:290200	13/24 (54%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		SIR2	<425..>465	CDD:294129	16/68 (24%)
		C2H2 Zn finger	434..454	CDD:275368	8/19 (42%)
		C2H2 Zn finger	461..482	CDD:275368	10/20 (50%)
		C2H2 Zn finger	490..509	CDD:275368	9/20 (45%)
		lambda-1	491..>603	CDD:212564	30/154 (19%)
		C2H2 Zn finger	575..595	CDD:275368	7/19 (37%)
		C2H2 Zn finger	720..740	CDD:275368	6/19 (32%)
		C2H2 Zn finger	752..771	CDD:275368	11/19 (58%)
si:ch211-222k6.1	XP_021324960.1	C2H2 Zn finger	60..80	CDD:275368
		C2H2 Zn finger	88..108	CDD:275368	5/9 (56%)
		C2H2 Zn finger	116..136	CDD:275368	12/19 (63%)
		C2H2 Zn finger	144..164	CDD:275368	9/19 (47%)
		zf-H2C2_2	156..181	CDD:316026	9/24 (38%)
		C2H2 Zn finger	172..192	CDD:275368	7/19 (37%)
		COG5048	196..607	CDD:227381	117/471 (25%)
		C2H2 Zn finger	200..220	CDD:275368	7/19 (37%)
		C2H2 Zn finger	228..248	CDD:275368	7/19 (37%)
		C2H2 Zn finger	256..276	CDD:275368	8/19 (42%)
		C2H2 Zn finger	284..304	CDD:275368	2/19 (11%)
		C2H2 Zn finger	312..332	CDD:275368	10/20 (50%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	368..388	CDD:275368	0/19 (0%)
		C2H2 Zn finger	396..416	CDD:275368	2/35 (6%)
		C2H2 Zn finger	424..444	CDD:275368	3/19 (16%)
		C2H2 Zn finger	452..472	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	6/43 (14%)
		C2H2 Zn finger	508..528	CDD:275368	5/32 (16%)
		C2H2 Zn finger	536..556	CDD:275368	2/20 (10%)
		C2H2 Zn finger	564..584	CDD:275368	6/19 (32%)
		C2H2 Zn finger	592..612	CDD:275368	11/19 (58%)
		C2H2 Zn finger	620..640	CDD:275368
		C2H2 Zn finger	648..666	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595218
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930