DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and zgc:173486

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_021324950.1	Gene:	zgc:173486 / 100006445	ZFINID:	ZDB-GENE-080305-13	Length:	737	Species:	Danio rerio

Alignment Length:	538	Identity:	143/538 - (26%)
Similarity:	221/538 - (41%)	Gaps:	101/538 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 KKQDNNQQVLSLDKNYLLVDPATAAAAAAAAGGDSGLAHHHTLTNGSIVDAKTGQTVLTAGSAAA 164
            |..:.|:.:    ||:..|.......:....|  ....|.|:|        :..||:.|......
Zfish   242 KSLERNEDM----KNHFNVHSTMKHFSCCLCG--KSYNHPHSL--------RRHQTIHTGERPYK 292

  Fly   165 KSH----FSSIGALH-----------LTQEECNEILIKRAIAAGHHQTHTITAADGSHHHA---- 210
            .|:    ||..|:|.           .|..:|.:..|:.:....|..||:..|.:.....:
Zfish   293 CSYCEKTFSESGSLRSHERIHTGEKPFTCTQCGKSFIRSSDRNRHMMTHSSAAINERQRQSLLKD 357

  Fly   211 --SGGTPSFCSVGGATTLLGDILPGISVQVQ-KVIQGLEDNEDSQGEAPNLKLEPGTLELSPKTE 272
              ....|..|.:...     |......|:|: :|:.|:||.|..     ::|.|..|     :|.
Zfish   358 SEKMSDPEPCRIKQE-----DTEEQTEVKVESEVLWGIEDEEKH-----HVKSEEET-----RTN 407

  Fly   273 LQESMHFSETDATIKKERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNT 337
            ...|:..:.|..     :..:|.:|||.|..|:.|..|.::|.||:|:.|:||.|.|:....|..
Zfish   408 TDGSVSMNSTAV-----KSLACTQCGKRFSRKYGLIIHMKIHAGEKPYKCSHCDKRFSKLRDLKA 467

  Fly   338 HLLLHSTERPYQCQECKKSF---------TLKHHLLT-----HSRVHSRERPFVCQECGRAFPLK 388
            |..:|..|:||:|..|.:||         |.|.|.|:     :..||.:.:||.|..||::|...
Zfish   468 HRKIHPKEKPYRCIACGRSFMDIFILQTHTKKFHELSEDMKNYFEVHLKLKPFSCSLCGKSFNRS 532

  Fly   389 RHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRI 453
            ..|..|.:.|:||:||.|..|.::|:|..:|..|...|.....:.|:.|..::.....|..|..|
Zfish   533 HILRKHQRNHSGEKPYKCSHCDKTFSQPEYLKKHKVIHTGRKRYKCSRCEKTYSNSENLKMHEMI 597

  Fly   454 H-GKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPN 517
            | ||.||:|..|||.|::...|..|| .:||||:.|.|..||:.||..::|..|:| :|....|.
Zfish   598 HTGKRPHTCDQCGKTFVRSSDLNRHM-LIHTGEKKHKCDQCGKTFLRTSDLKIHLR-SHTEDKPY 660

  Fly   518 TSSATIIANQQLQQAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTDANGVARPQFVCRECGSAF 582
            ..|.   ..:..::..|....|:.|                         .|..:.||.:||..|
Zfish   661 PCSE---CGKSFKRQSHLSKHQKMH-------------------------AAVKEHVCLKCGKTF 697

  Fly   583 NSREALALHLRLHTGDKS 600
            |....|..|.|:|||:.:
Zfish   698 NKAGYLKQHQRMHTGENT 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	32/97 (33%)
		C2H2 Zn finger	294..314	CDD:275368	8/19 (42%)
		zf-H2C2_2	306..331	CDD:290200	11/24 (46%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	8/33 (24%)
		zf-H2C2_2	362..385	CDD:290200	9/27 (33%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		zf-H2C2_2	390..415	CDD:290200	10/24 (42%)
		C2H2 Zn finger	406..426	CDD:275368	6/19 (32%)
		SIR2	<425..>465	CDD:294129	12/40 (30%)
		C2H2 Zn finger	434..454	CDD:275368	4/19 (21%)
		C2H2 Zn finger	461..482	CDD:275368	8/20 (40%)
		C2H2 Zn finger	490..509	CDD:275368	7/18 (39%)
		lambda-1	491..>603	CDD:212564	26/110 (24%)
		C2H2 Zn finger	575..595	CDD:275368	8/19 (42%)
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
zgc:173486	XP_021324950.1	C2H2 Zn finger	16..36	CDD:275368
		C2H2 Zn finger	44..64	CDD:275368
		zf-H2C2_2	56..81	CDD:316026
		C2H2 Zn finger	72..92	CDD:275368
		C2H2 Zn finger	169..189	CDD:275370
		zf-H2C2_2	181..204	CDD:316026
		C2H2 Zn finger	197..217	CDD:275370
		C2H2 Zn finger	223..257	CDD:275368	4/18 (22%)
		COG5048	250..681	CDD:227381	127/469 (27%)
		C2H2 Zn finger	265..285	CDD:275368	6/29 (21%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
		C2H2 Zn finger	321..341	CDD:275368	3/19 (16%)
		C2H2 Zn finger	424..444	CDD:275368	8/19 (42%)
		C2H2 Zn finger	452..472	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..498	CDD:275368	4/17 (24%)
		C2H2 Zn finger	522..542	CDD:275368	6/19 (32%)
		C2H2 Zn finger	550..570	CDD:275368	6/19 (32%)
		C2H2 Zn finger	578..598	CDD:275368	4/19 (21%)
		C2H2 Zn finger	606..626	CDD:275368	8/20 (40%)
		C2H2 Zn finger	634..654	CDD:275368	8/20 (40%)
		C2H2 Zn finger	662..682	CDD:275368	3/22 (14%)
		C2H2 Zn finger	690..710	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595240
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930