DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ReepB and REEP6

DIOPT Version :9

Sequence 1:	NP_001188928.1	Gene:	ReepB / 36569	FlyBaseID:	FBgn0033906	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_001316485.1	Gene:	REEP6 / 92840	HGNCID:	30078	Length:	211	Species:	Homo sapiens

Alignment Length:	154	Identity:	79/154 - (51%)
Similarity:	111/154 - (72%)	Gaps:	4/154 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 TKVFDTVEEKTGVDRVNIFVGAVGLCAIYLIFGWGAQLLCNIIGVLYPAYISIHAIESSTKQDDT 92
            |:|...:|.||||::..:..|||.|.::||:||:||.||||:||.:||||.||.||||.:|.|||
Human    19 TEVLGALEAKTGVEKRYLAAGAVTLLSLYLLFGYGASLLCNLIGFVYPAYASIKAIESPSKDDDT 83

  Fly    93 KWLIYWVTFGIFTVIEFFSSLLTSVIPFYWLLKCAFLIWCMLPTEQNGSTIIYNKLVRPYFLKHH 157
            .||.|||.:.:|.:.||||.||.|..|||::.|||||::||.|...||:.::|.::|||.||:||
Human    84 VWLTYWVVYALFGLAEFFSDLLLSWFPFYYVGKCAFLLFCMAPRPWNGALMLYQRVVRPLFLRHH 148

  Fly   158 ESVDRIIDD----GMKKAAGVLKH 177
            .:||||::|    .:..|||:.::
Human   149 GAVDRIMNDLSGRALDAAAGITRN 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ReepB	NP_001188928.1	TB2_DP1_HVA22	63..151	CDD:281172	49/87 (56%)
REEP6	NP_001316485.1	TB2_DP1_HVA22	66..143	CDD:308643	42/76 (55%)
REEP6	NP_001316485.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..211
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6125
eggNOG	1	0.900	-	-		E1_COG5052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	179	1.000	Inparanoid score	I4020
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57200
OrthoDB	1	1.010	-	-		D1473891at2759
OrthoFinder	1	1.000	-	-		FOG0000849
OrthoInspector	1	1.000	-	-		mtm8564
orthoMCL	1	0.900	-	-		OOG6_100903
Panther	1	1.100	-	-	O	PTHR12300
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2369
SonicParanoid	1	1.000	-	-		X536
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870