Protein Alignment CG8323 and UCP2

DIOPT Version :10

• Sequence 1: NP_610933.1
• Gene: CG8323 / 36566
• FlyBaseID: FBgn0033903
• Length: 303
• Species: Drosophila melanogaster
• Sequence 2: NP_003346.2
• Gene: UCP2 / 7351
• HGNCID: 12518
• Length: 309
• Species: Homo sapiens
• Alignment Length: 295
• Identity: 80/295 - (27%)
• Similarity: 139/295 - (47%)
• Gaps: 16/295 - (5%)

  Fly     2 ATSDFVLGGLASVGATFFTNPIEVIKTRIQLQGEL--AARGTYVEPYKGIVNAFITVAKNDGITG 64
            ||..|:..|.|:..|...|.|::..|.|:|:|||.  ..|.|....|:|::...:|:.:.:|...
Human    13 ATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77

  Fly    65 LQKGLAPALYFQFIINSFRLSIYSEAMERRWMHNRKGE-VSYGMGLLWGAIGGVVGCYFSSPFFL 128
            |..||...|..|....|.|:.:|....:   .:.:..| .|.|..||.|:..|.:....:.|..:
Human    78 LYNGLVAGLQRQMSFASVRIGLYDSVKQ---FYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDV 139

  Fly   129 IKTQLQSQAAKQIAVGYQHAHTSMTDALRQIYSRNGVRGLWRGSVAALPRAALGSGAQIATFGKT 193
            :|.:.|:||    ..|....:.|..:|.:.|....|.||||:|:...:.|.|:.:.|::.|:...
Human   140 VKVRFQAQA----RAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLI 200

  Fly   194 KALLVQYDLVTQPTLNSFSAGLIAGSIMSVAITPPDVITTRLYNQGVDAEGRGLLYRGWLDCFVK 258
            |..|::.:|:|......|::...||...:|..:|.||:.||..|..:..      |.....|.:.
Human   201 KDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQ------YSSAGHCALT 259

  Fly   259 ILRSEGVYGMYKGFWANYLRIAPHSTLVLLFFDEL 293
            :|:.||....||||..::||:...:.::.:.:::|
Human   260 MLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQL 294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8323	NP_610933.1	PTZ00169	5..293	CDD:240302	77/290 (27%)
UCP2	NP_003346.2	Mito_carr	10..111	CDD:395101	28/100 (28%)
		Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	11..106		28/95 (29%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	16..63		16/46 (35%)
		transmembrane domain	17..34		5/16 (31%)
		transmembrane domain	78..100		7/21 (33%)
		Mito_carr	112..206	CDD:395101	28/97 (29%)
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	114..203		26/92 (28%)
		transmembrane domain	120..137		4/16 (25%)
		transmembrane domain	174..197		7/22 (32%)
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	212..297		22/89 (25%)
		transmembrane domain	216..235		4/18 (22%)
		Mito_carr	217..299	CDD:395101	22/84 (26%)
		purine nucleotide binding domain	264..273		4/8 (50%)
		transmembrane domain	269..291		6/21 (29%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	278..285		2/6 (33%)