DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3m and eif3m

DIOPT Version :9

Sequence 1:	NP_001286407.1	Gene:	eIF3m / 36565	FlyBaseID:	FBgn0033902	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_001019906.1	Gene:	eif3m / 334626	ZFINID:	ZDB-GENE-040426-2643	Length:	375	Species:	Danio rerio

Alignment Length:	372	Identity:	173/372 - (46%)
Similarity:	256/372 - (68%)	Gaps:	2/372 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SHPVFIDLSLDEQVQELRKYFKKLGAEISSEKSNKGVEDDLHKIIGVCDVCFKDGEPSQIDGILN 67
            |.|.|||::.::|..|||.|.|..|||||.|.|..|:..||.:||..||||.|| :...::.::|
Zfish     2 SVPAFIDITEEDQASELRSYLKSKGAEISEENSEGGLHVDLAQIIEACDVCLKD-DDKDVESVMN 65

  Fly    68 SIVSIMITIPLDRGENIVLAYCEKMTKAPNLPLGKVCLQSLWRLFNNLDTASPLRYHVYYHLVQV 132
            ||||:::.:..::.|.::.:.|||:.|........:.:|.|..||:.:|..:|:|:.||..|::|
Zfish    66 SIVSLLLILETEKQEALIESLCEKLVKFREGERPSLRMQLLSNLFHGMDENTPVRHTVYCSLIKV 130

  Fly   133 AKQCEQVLEVFSGVDQLKSQFANCPPSSEQMQKLYRLLHDVTKD-TNLELSSKVMIELLGTYTAD 196
            |..|..:..:.:.:||::....:...::|:...|.||:::...| ...|.::|||:||||:||.|
Zfish   131 AATCNAIAFMPTDLDQVRKWIVDWNLNTEKKHTLLRLVYEALVDCKKSEAAAKVMVELLGSYTED 195

  Fly   197 NACVAREDAMKCIVTALADPNTFLLDPLLSLKPVRFLEGDLIHDLLSIFVSEKLPAYVQFYEDHR 261
            ||..||.||.:|||.||.||||:|.|.||:|||||||||:||||||:||||.||.:||:||:.::
Zfish   196 NASQARVDAHRCIVRALKDPNTYLFDHLLALKPVRFLEGELIHDLLTIFVSAKLISYVKFYQSNK 260

  Fly   262 EFVNSQGLNHEQNMKKMRLLTFMQLAESSPEMTFETLTKELQINEDEVEPFVIEVLKTKLVRARL 326
            :|:.|.||:|||||.||||||||.:|....|::|||:.:||||..::||.|||:.::||:|.:::
Zfish   261 DFIESLGLSHEQNMSKMRLLTFMGMAVEMKEISFETMQQELQIGAEDVEAFVIDAVRTKMVYSKI 325

  Fly   327 DQANQKVHISSTMHRTFGAPQWEQLRDLLQAWKENLSTVREGLTSVS 373
            ||..:||.:|.:.|||||..||:||.|.|.:||:|||||:..|.::|
Zfish   326 DQTQRKVVVSHSTHRTFGKQQWQQLYDTLCSWKQNLSTVKSSLQTLS 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3m	NP_001286407.1	PCI	236..336	CDD:396121	54/99 (55%)
eIF3m	NP_001286407.1	eIF3m_C_helix	341..369	CDD:407846	17/27 (63%)
eif3m	NP_001019906.1	PAM	271..357	CDD:214803	45/85 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595160
Domainoid	1	1.000	186	1.000	Domainoid score	I3300
eggNOG	1	0.900	-	-		E1_KOG2753
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4639
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2328
OMA	1	1.010	-	-		QHG54703
OrthoDB	1	1.010	-	-		D353768at33208
OrthoFinder	1	1.000	-	-		FOG0005091
OrthoInspector	1	1.000	-	-		oto38697
orthoMCL	1	0.900	-	-		OOG6_103094
Panther	1	1.100	-	-	LDO	PTHR15350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2512
SonicParanoid	1	1.000	-	-		X6210
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800