DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3m and EIF3M

DIOPT Version :9

Sequence 1:	NP_001286407.1	Gene:	eIF3m / 36565	FlyBaseID:	FBgn0033902	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_006351.2	Gene:	EIF3M / 10480	HGNCID:	24460	Length:	374	Species:	Homo sapiens

Alignment Length:	372	Identity:	175/372 - (47%)
Similarity:	256/372 - (68%)	Gaps:	2/372 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SHPVFIDLSLDEQVQELRKYFKKLGAEISSEKSNKGVEDDLHKIIGVCDVCFKDGEPSQIDGILN 67
            |.|.|||:|.::|..|||.|.|..|||||.|.|..|:..||.:||..||||.|: :...::.::|
Human     2 SVPAFIDISEEDQAAELRAYLKSKGAEISEENSEGGLHVDLAQIIEACDVCLKE-DDKDVESVMN 65

  Fly    68 SIVSIMITIPLDRGENIVLAYCEKMTKAPNLPLGKVCLQSLWRLFNNLDTASPLRYHVYYHLVQV 132
            |:||:::.:..|:.|.::.:.|||:.|........:.||.|..||:.:|..:|:||.||..|::|
Human    66 SVVSLLLILEPDKQEALIESLCEKLVKFREGERPSLRLQLLSNLFHGMDKNTPVRYTVYCSLIKV 130

  Fly   133 AKQCEQVLEVFSGVDQLKSQFANCPPSSEQMQKLYRLLHDVTKD-TNLELSSKVMIELLGTYTAD 196
            |..|..:..:.:.:||::...::...::|:...|.|||::...| ...:.:||||:||||:||.|
Human   131 AASCGAIQYIPTELDQVRKWISDWNLTTEKKHTLLRLLYEALVDCKKSDAASKVMVELLGSYTED 195

  Fly   197 NACVAREDAMKCIVTALADPNTFLLDPLLSLKPVRFLEGDLIHDLLSIFVSEKLPAYVQFYEDHR 261
            ||..||.||.:|||.||.|||.||.|.||:||||:||||:||||||:||||.||.:||:||::::
Human   196 NASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFLEGELIHDLLTIFVSAKLASYVKFYQNNK 260

  Fly   262 EFVNSQGLNHEQNMKKMRLLTFMQLAESSPEMTFETLTKELQINEDEVEPFVIEVLKTKLVRARL 326
            :|::|.||.|||||.||||||||.:|..:.|::|:|:.:||||..|:||.|||:.::||:|..::
Human   261 DFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCKI 325

  Fly   327 DQANQKVHISSTMHRTFGAPQWEQLRDLLQAWKENLSTVREGLTSVS 373
            ||..:||.:|.:.|||||..||:||.|.|.|||:||:.|:..|.|:|
Human   326 DQTQRKVVVSHSTHRTFGKQQWQQLYDTLNAWKQNLNKVKNSLLSLS 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3m	NP_001286407.1	PCI	236..336	CDD:396121	54/99 (55%)
eIF3m	NP_001286407.1	eIF3m_C_helix	341..369	CDD:407846	16/27 (59%)
EIF3M	NP_006351.2	PINT	269..357	CDD:214509	46/87 (53%)
EIF3M	NP_006351.2	Interaction with HSV-1 and HSV-2	344..374		15/29 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159103
Domainoid	1	1.000	188	1.000	Domainoid score	I3333
eggNOG	1	0.900	-	-		E1_KOG2753
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4639
Inparanoid	1	1.050	343	1.000	Inparanoid score	I2344
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54703
OrthoDB	1	1.010	-	-		D353768at33208
OrthoFinder	1	1.000	-	-		FOG0005091
OrthoInspector	1	1.000	-	-		oto91256
orthoMCL	1	0.900	-	-		OOG6_103094
Panther	1	1.100	-	-	LDO	PTHR15350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2512
SonicParanoid	1	1.000	-	-		X6210
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800