Protein Alignment O-fut1 and POFUT1

DIOPT Version :10

• Sequence 1: NP_610931.1
• Gene: O-fut1 / 36564
• FlyBaseID: FBgn0033901
• Length: 402
• Species: Drosophila melanogaster
• Sequence 2: NP_056167.1
• Gene: POFUT1 / 23509
• HGNCID: 14988
• Length: 388
• Species: Homo sapiens
• Alignment Length: 392
• Identity: 172/392 - (43%)
• Similarity: 237/392 - (60%)
• Gaps: 27/392 - (6%)

  Fly    11 VNLILLLISSTCAQLGG-DPNGYLTYCPCMGRFGNQADHFLGSLAFAKALNRTLILPPWVEYR-- 72
            |:.:|||:.......|. ||.|||.|||||||||||||||||||||||.|||||.:|||:||:
Human    12 VSFLLLLLPLPGMPAGSWDPAGYLLYCPCMGRFGNQADHFLGSLAFAKLLNRTLAVPPWIEYQHH 76

  Fly    73 RGELRSRQVPFNTYFEVEPLKEYHRVITMADFMWHLADDIWPESERVSFCYKERYSLQQEKNDPD 137
            :....:..|.:..||::|||:.|||||::.|||..||...||..:||::|::     ...:..||
Human    77 KPPFTNLHVSYQKYFKLEPLQAYHRVISLEDFMEKLAPTHWPPEKRVAYCFE-----VAAQRSPD 136

  Fly   138 KPNCHAKDGNPFGPFWDTFHIDFVRSEFYAPLHFDVHHSNEAAKWQTKYPAESYPVLAFTGAPAS 202
            |..|..|:|||||||||.||:.|.:||.:..:.|...:..:   |..::..:.:||||..||||.
Human   137 KKTCPMKEGNPFGPFWDQFHVSFNKSELFTGISFSASYREQ---WSQRFSPKEHPVLALPGAPAQ 198

  Fly   203 FPVQLENCKLQRYLQWSQRYREASKDFIREQLPRGAFLGIHLRNGIDWVRACEHVKD---SQHLF 264
            |||..|:..||:|:.||....:..:..|...|.| .::|||||.|.||..||..:||   ..|..
Human   199 FPVLEEHRPLQKYMVWSDEMVKTGEAQIHAHLVR-PYVGIHLRIGSDWKNACAMLKDGTAGSHFM 262

  Fly   265 ASPQCLGYKNERGA-LYPELCMPSKEAIIRQLKRTIKNVRQTQPDNEIKSVFVASDSNHMIGELN 328
            |||||:||.....| |...:|:|..:.|.|.:|..::::       :.:||:||:||...:.||.
Human   263 ASPQCVGYSRSTAAPLTMTMCLPDLKEIQRAVKLWVRSL-------DAQSVYVATDSESYVPELQ 320

  Fly   329 TALSRMGISVHKLPEDDPYLDLAILGQSNHFIGNCISSYSAFEKRERDVHGFPSYFWGF---PKE 390
             .|.:..:.|..|..:...:||.||||::||||||:||::||.|||||:.|.||.|:|.   ||.
Human   321 -QLFKGKVKVVSLKPEVAQVDLYILGQADHFIGNCVSSFTAFVKRERDLQGRPSSFFGMDRPPKL 384

  Fly   391 KD 392
            :|
Human   385 RD 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
O-fut1	NP_610931.1	O-FucT-1	28..388	CDD:211388	164/368 (45%)
POFUT1	NP_056167.1	O-FucT-1	30..379	CDD:211388	164/365 (45%)
		Prevents secretion from ER. /evidence=ECO:0000255	385..388		1/2 (50%)