Protein Alignment CysRS-m and CARS2

DIOPT Version :10

• Sequence 1: NP_610930.1
• Gene: CysRS-m / 36563
• FlyBaseID: FBgn0033900
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_078813.1
• Gene: CARS2 / 79587
• HGNCID: 25695
• Length: 564
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 215/536 - (40%)
• Similarity: 300/536 - (55%)
• Gaps: 35/536 - (6%)

  Fly    38 WRKPIGQHTGINIYNHGLRQKVPLILRNPQMVTWYTCGPTVYDSAHLGHASTYVKVDILQRILRD 102
            |.:|.|:.||:.:||....:|.|||:.:.:..:||:|||||||.||||||.:||:.||::|||..
Human    42 WLQPTGRETGVQVYNSLTGRKEPLIVAHAEAASWYSCGPTVYDHAHLGHACSYVRFDIIRRILTK 106

  Fly   103 YFKINLVTAMNITDVDDKIIKRAQLAGLDWQKMARAYEAEFRQDMLRLNVQAPDVRSHVTTTMPV 167
            .|..::|..|.||||||||||||....:....:|..||.:|:|||..|.|..|.|...||..:|.
Human   107 VFGCSIVMVMGITDVDDKIIKRANEMNISPASLASLYEEDFKQDMAALKVLPPTVYLRVTENIPQ 171

  Fly   168 IIQFIQQLIDGKQAYVTPDNSVYFDV-SKSKNYGKLQNL--GLSEDKLDPIKRNTADFALWKARK 229
            ||.||:.:|....||.|...:||||: |:...||||..:  |...:..|..||:.:|||||||.|
Human   172 IISFIEGIIARGNAYSTAKGNVYFDLKSRGDKYGKLVGVVPGPVGEPADSDKRHASDFALWKAAK 236

  Fly   230 SGSEPTWAAPWGGEGRPGWHIECSAIAGLFFGRQLDIHAGGLDLRFPHHENEEAQCCARYKTDQW 294
            . .|..||:|| |.|||||||||||||.:.||.|||||:||:||.|||||||.|||...::.:||
Human   237 P-QEVFWASPW-GPGRPGWHIECSAIASMVFGSQLDIHSGGIDLAFPHHENEIAQCEVFHQCEQW 299

  Fly   295 VNYWVHTGQLHMVGDREKMSKSLGNTISVSELLKKYTADEFRMACLLSNYRNAMPYSDQLMVTAR 359
            .||::|:|.||..|..|||||||.|.|::.:.||.::.|.||..||.|:||:|:.|||..|:.|:
Human   300 GNYFLHSGHLHAKGKEEKMSKSLKNYITIKDFLKTFSPDVFRFFCLRSSYRSAIDYSDSAMLQAQ 364

  Fly   360 QTLQRFRNFQADLSAYTQFLKPVHLLDEGALKAQLTHTVTEFDNCLRDDFDTARAISVLIDQMSS 424
            |.|....:|..|..||.:.......:.|..|..:|:.|.......|.|||||.|    ::|.:..
Human   365 QLLLGLGSFLEDARAYMKGQLACGSVREAMLWERLSSTKRAVKAALADDFDTPR----VVDAILG 425

  Fly   425 ISRCINEQ------QVDAQEEPAYCIDLLLAAGNFINRAIVTFGLSELQDKESLQEKVSFTDHSI 483
            ::...|.|      :.:....||    :..|..::..:...|.|:|....:....:....|.|.:
Human   426 LAHHGNGQLRASLKEPEGPRSPA----VFGAIISYFEQFFETVGISLANQQYVSGDGSEATLHGV 486

  Fly   484 DPNLLVNDVINVRGRMRERA-----TSGNVKNPQ------LLAACDELRSLLQQHGIQVRDHKQG 537
                 |::::..|.::|:.|     .:|:.:..|      ||.|||.||..|..|||.::|....
Human   487 -----VDELVRFRQKVRQFALAMPEATGDARRQQLLERQPLLEACDTLRRGLTAHGINIKDRSST 546

  Fly   538 SSWVFAVSCEKQDDKS 553
            :|....:....:|.||
Human   547 TSTWELLDQRTKDQKS 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CysRS-m	NP_610930.1	CysS	48..543	CDD:439985	207/514 (40%)
CARS2	NP_078813.1	PTZ00399	35..563	CDD:240402	215/536 (40%)
		'HIGH' region	80..90		8/9 (89%)
		'KIIK' region	124..127		2/2 (100%)
		'KMSKS' region	317..321		3/3 (100%)