DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and DHX38

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_054722.2	Gene:	DHX38 / 9785	HGNCID:	17211	Length:	1227	Species:	Homo sapiens

Alignment Length:	1280	Identity:	491/1280 - (38%)
Similarity:	688/1280 - (53%)	Gaps:	228/1280 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 AEFPDSLVQNLQRIINLMRPSRPGGASQEKTVG-DKKEDKKSQLLKMFPGLALPNDTYSKKEESD 120
            |..|...:..|..:.:|.|..|     :||..| |||:.|.|              :|...|||.
Human    41 APAPRPSLLGLDLLASLKRRER-----EEKDDGEDKKKSKVS--------------SYKDWEESK 86

  Fly   121 DDEKVKAKPEKHSETHKKTDMSDVDAAMMELEALAPGEGATLVRPHKEVSSRDRHKR-------- 177
            ||:|                         :.|.....:....:|       :|||.|
Human    87 DDQK-------------------------DAEEEGGDQAGQNIR-------KDRHYRSARVETPS 119

  Fly   178 -----------RSRDRDTKRR-----SRSREDRHSDRRRSRSRDKERRRRSRSRDNRRRSR--SR 224
                       |||.|:.:||     :.|:|::...:.:||.||.:|:   |.||.|.|||  ||
Human   120 HPGGVSEEFWERSRQRERERREHGVYASSKEEKDWKKEKSRDRDYDRK---RDRDERDRSRHSSR 181

  Fly   225 EDRD--RDRDRRHKSSSSRDHHERRRRSRSRST--ERRDRRDRSRDCSEKMPPPSAAMTDDPEAG 285
            .:||  .:|..|.....|..|..:...:.||||  |.......||....:.|.|:.:..|...:.
Human   182 SERDGGSERSSRRNEPESPRHRPKDAATPSRSTWEEEDSGYGSSRRSQWESPSPTPSYRDSERSH 246

  Fly   286 KIYS--------GKIANIVP-----------------FGCFVQLF-GLRKRWEGLVHISQLRAEG 324
            ::.:        ||.::..|                 .|...:|. |..:|.||        .||
Human   247 RLSTRDRDRSVRGKYSDDTPLPTPSYKYNEWADDRRHLGSTPRLSRGRGRREEG--------EEG 303

  Fly   325 RVTDVTEVVTRNQTVKVKVMSITGQKVSLSMKEVDQ-----DSGKD--LNPLSHAPEDDESLRDR 382
            ...|..|               ..|:.....::.|:     |.|.|  .|||:::.||  .:|.|
Human   304 ISFDTEE---------------ERQQWEDDQRQADRDWYMMDEGYDEFHNPLAYSSED--YVRRR 351

  Fly   383 NPDGPFSSSTSMLNLQGNGMEGDEHESRKRVTRISSP--------ERWEIKQMISSGVLDRSEMP 439
                                  ::|..:::..|||:.        ||||..:|::|||:.|.|:
Human   352 ----------------------EQHLHKQKQKRISAQRRQINEDNERWETNRMLTSGVVHRLEV- 393

  Fly   440 DFDEETGLLPKDEDDEADIEIEIVEEEPPFLSGHGRALHDLSPVRIVKNPDGSLAQAAMMQSALS 504
              ||:.     :||:.|.:.:.:....||||.|.........||..||:....||..|...|...
Human   394 --DEDF-----EEDNAAKVHLMVHNLVPPFLDGRIVFTKQPEPVIPVKDATSDLAIIARKGSQTV 451

  Fly   505 KERREQKMLQREQEIEAMPTSLNKNWIDPLPEDESRSLAANMRG--MAAAPPEVPEWKKHVIGGK 567
            ::.||||..::.|         :|:|          .||....|  |.....|.|: |.....||
Human   452 RKHREQKERKKAQ---------HKHW----------ELAGTKLGDIMGVKKEEEPD-KAVTEDGK 496

  Fly   568 -------------------KSSFGKKTDLTLVEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGS 613
                               .|.|.||.  :::||||.|||:.::.:|:..:.||.|:||:|||||
Human   497 VDYRTEQKFADHMKRKSEASSEFAKKK--SILEQRQYLPIFAVQQELLTIIRDNSIVIVVGETGS 559

  Fly   614 GKTTQITQYLGECGFTARGKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETI 678
            |||||:||||.|.|:|..|.||||||||||||||||||:||.|..||:||||.||||||||..|:
Human   560 GKTTQLTQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIRFEDCTSENTL 624

  Fly   679 IKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDA 743
            |||||||:||||.|.||:|..||.|::||||||:::||||||||:..|.:|.:|||||||||:||
Human   625 IKYMTDGILLRESLREADLDHYSAIIMDEAHERSLNTDVLFGLLREVVARRSDLKLIVTSATMDA 689

  Fly   744 VKFSQYFFKAPIFTIPGRTFPVEVLYTKEPETDYLDASLITVMQIHLREPPGDILLFLTGQEEID 808
            .||:.:|...|||.||||||||::|::|.|:.||::|::...:|:||...|||||:|:.|||:|:
Human   690 EKFAAFFGNVPIFHIPGRTFPVDILFSKTPQEDYVEAAVKQSLQVHLSGAPGDILIFMPGQEDIE 754

  Fly   809 TACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIF 873
            ...:.:.|.::.| .:.|.|.:||:||.|||::|.:||..||.|.||.::||||||||||:|||.
Human   755 VTSDQIVEHLEEL-ENAPALAVLPIYSQLPSDLQAKIFQKAPDGVRKCIVATNIAETSLTVDGIM 818

  Fly   874 YVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPV 938
            :|:|.|:.|.||:|.:.|||:|.:.|||||.|.||:|||||||||:.:||||:.||::|:|.|.|
Human   819 FVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSGRAGRTGPGQCFRLYTQSAYKNELLTTTV 883

  Fly   939 PEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRRMAE 1003
            |||||||||..||.||::|:.|||.|.|||.||.::::.::.||..|.|||:.|.||..||.|.|
Human   884 PEIQRTNLANVVLLLKSLGVQDLLQFHFMDPPPEDNMLNSMYQLWILGALDNTGGLTSTGRLMVE 948

  Fly  1004 FPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDKQALADQKKAKFNQAEGDHLTLLA 1068
            |||:|.||||||:|..:.||.|||.|||||||..:|||||.::..:||.:.||...|.||||.|.
Human   949 FPLDPALSKMLIVSCDMGCSSEILLIVSMLSVPAIFYRPKGREEESDQIREKFAVPESDHLTYLN 1013

  Fly  1069 VYNSWKNNKFSNAWCYENFVQIRTLKRSQDVRKQLLGIMDRHKLDVVSAGKNSVRIQKAICSGFF 1133
            ||..||||.:|..||.::|:..:.:::.::||.||..||.:.::.:.|.|.:...::|.||:.:|
Human  1014 VYLQWKNNNYSTIWCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSLASCGTDWDIVRKCICAAYF 1078

  Fly  1134 RNAAKKDPQEGYRTLVDSQVVYIHPSSALFNR--QPEWVIYHELVQTTKEYMREVTTIDPKWLVE 1196
            ..|||......|..:......::||:|:||..  .|::::|||||.||||||:.||.:|.:||.|
Human  1079 HQAAKLKGIGEYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHELVMTTKEYMQCVTAVDGEWLAE 1143

  Fly  1197 FAPSFFRFSDPTKLSKFKKNQRLEPLYNKYEEPNAWRISRVRRRR 1241
            ..|.|:......| |:.:..:|.:...:..||..|....::|.||
Human  1144 LGPMFYSVKQAGK-SRQENRRRAKEEASAMEEEMALAEEQLRARR 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189	16/108 (15%)
pea	NP_610928.1	HrpA	573..1221	CDD:224557	345/649 (53%)
DHX38	NP_054722.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..320		74/336 (22%)
		HrpA	515..1146	CDD:224557	342/633 (54%)
		DEAH box	652..655		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1155..1227		9/34 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720