Protein Alignment pea and DHX34

DIOPT Version :10

• Sequence 1: NP_610928.1
• Gene: pea / 36561
• FlyBaseID: FBgn0086895
• Length: 1242
• Species: Drosophila melanogaster
• Sequence 2: NP_055496.2
• Gene: DHX34 / 9704
• HGNCID: 16719
• Length: 1143
• Species: Homo sapiens
• Alignment Length: 654
• Identity: 238/654 - (36%)
• Similarity: 359/654 - (54%)
• Gaps: 42/654 - (6%)

  Fly   503 LSKERREQK-MLQREQEIEAMPTSLNKNWIDPLPEDESRSLAANMRGMAA----APPE-VPEWKK 561
            |...|:|:| ..|.:..|.|: ..|.:.: ||........|....||...    .|.| |.|:::
Human    73 LKTSRKEEKDPGQPKHSIPAL-ADLPRTY-DPRYRINLSVLGPATRGSQGLGRHLPAERVAEFRR 135

  Fly   562 HVIG----GKKSSFGKKTDLTLVEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQY 622
            .::.    |:|.:||:...|.  .:|.:|||.:..:.:::.:.::|:::|.|:||.||:||:.||
Human   136 ALLHYLDFGQKQAFGRLAKLQ--RERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQY 198

  Fly   623 LGECGFTARGKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGML 687
            |...||:   .:.||||||:|.:|:||||..|...:.|.:|||.||||...|..|.|.::|.|:|
Human   199 LLAAGFS---HVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLL 260

  Fly   688 LRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKFSQYFFK 752
            ||:...|..|..|.|:::||.|||.:|.|.|.|:|:..:..||:||:|:.|||::...||.||..
Human   261 LRQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYFSN 325

  Fly   753 APIFTIPGRTFPVEVLY---TKEPET---DYLDAS--LITVMQIHLREPP---GDILLFLTGQEE 806
            ||:..:|||.||:.|:|   ..||.|   :.||..  |..:..|..:.||   ||:|:||:|..|
Human   326 APVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPRPFLRVLESIDHKYPPEERGDLLVFLSGMAE 390

  Fly   807 IDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDG 871
            |..    :.|..::........::||::|||....|.::||.||.|.||.:::|||||||:||||
Human   391 ISA----VLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILSTNIAETSVTIDG 451

  Fly   872 IFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPT 936
            |.:|||.|.||:..|:.:..:..|....||||:|:||.|||||||||..:|||.|..| |...|.
Human   452 IRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCFRLYAESDY-DAFAPY 515

  Fly   937 PVPEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRRM 1001
            |||||:|..|.:.|||:|:|.:.|...|.|::.||..||..|:..|....|||....||.:|..:
Human   516 PVPEIRRVALDSLVLQMKSMSVGDPRTFPFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLL 580

  Fly  1002 AEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDKQALADQKKAKFNQAEGDHLTL 1066
            |:.|::..:.||||:.......:.:|||.:.||||:.|.|...........:......:||..||
Human   581 AQLPVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFTL 645

  Fly  1067 LAVYNSW-----KNNKFSNAWCYENFVQIRTLKRSQDVRKQLLGIMDRHKL----DVVSAGKNSV 1122
            ..|:|:|     :.::.|..||....::...|....::|:|...:::.|.|    .....|.:..
Human   646 FNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAGAQAAQVGDSYS 710

  Fly  1123 RIQK 1126
            |:|:
Human   711 RLQQ 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	GH2-like_DHX8	7..74	CDD:409668
		S1_DHX8_helicase	285..363	CDD:240189
		HrpA	578..>1203	CDD:441249	216/569 (38%)
DHX34	NP_055496.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..94		6/19 (32%)
		HrpA	160..>624	CDD:441249	197/471 (42%)
		DEAH box	279..282		2/2 (100%)
		Negatively regulates interaction with UPF1. /evidence=ECO:0000269|PubMed:26841701	701..955		3/14 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	724..766
		OB_NTP_bind	800..911	CDD:400182
		Required for phosphorylation of UPF1. Not required for interaction with UPF1. /evidence=ECO:0000269|PubMed:26841701	810..1143
		Required for the interaction with SMG1 and subsequent phosphorylation of UPF1. /evidence=ECO:0000269|PubMed:26841701	957..1143