DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and DHX57

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_945314.1	Gene:	DHX57 / 90957	HGNCID:	20086	Length:	1386	Species:	Homo sapiens

Alignment Length:	1362	Identity:	325/1362 - (23%)
Similarity:	531/1362 - (38%)	Gaps:	409/1362 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 SRSRDNRRRSRSREDRDRDRDR-----------RHKSSSS--------RDHHERRRRSRSRSTER 257
            |.||...|.|.|...:...|.:           .|.:|.:        ||..|:...:.|.....
Human    68 SESRRPSRPSNSNISKGESRPKWKPKAKVPLQTLHMTSENQEKVKALLRDLQEQDADAGSERGLS 132

  Fly   258 RDRRDRSRDC--SEKMPP----PSAAMTDDPEAGKIYSGKIANIVPF------------------ 298
            .:..|...||  .|:..|    ||.....||..   |:| :|::.|:
Human   133 GEEEDDEPDCCNDERYWPAGQEPSLVPDLDPLE---YAG-LASVEPYVPEFTVSPFAVQKLSRYG 193

  Fly   299 --------------------------GCFVQLFGLR-KRWEGLVHISQLRAEGRVTDVTEVVTRN 336
                                      .||.:.||.| |..|.:..||          :.|.:.:.
Human   194 FNTERCQAVLRMCDGDVGASLEHLLTQCFSETFGERMKISEAVNQIS----------LDECMEQR 248

  Fly   337 QTVKVKVMSITGQKVSLSMKEVDQDSGKDLNPLSHAPEDDESLRDRNPDGPFSSSTSMLNLQGNG 401
            |.....:.||.|:|....::......|.:|..|:      ...|...|      ..|..|:|.|.
Human   249 QEEAFALKSICGEKFIERIQNRVWTIGLELEYLT------SRFRKSKP------KESTKNVQENS 301

  Fly   402 ME-------GDEHESRKRVTRISSPERWEIKQMISSGVLDRSEMPDFDEETGLLPKDEDDEADIE 459
            :|       |:        .:..|..|:            :.|:|. ::..|.:.:..||.....
Human   302 LEICKFYLKGN--------CKFGSKCRF------------KHEVPP-NQIVGRIERSVDDSHLNA 345

  Fly   460 IE----IVEEEPPFLSGHGRALHDLSPVRIVKNPDGSLAQAA-------MMQSALSKERREQ--- 510
            ||    :.|.|..|...|.....  :|:....:.:.:|..|.       :...||:.....:
Human   346 IEDASFLYELEIRFSKDHKYPYQ--APLVAFYSTNENLPLACRLHISEFLYDKALTFAETSEPVV 408

  Fly   511 ----KMLQREQEIEAMPTSLNKNWIDP--------------------------------LPEDES 539
                .:|:.|.||..:.|:.:..:.||                                :||.|.
Human   409 YSLITLLEEESEIVKLLTNTHHKYSDPPVNFLPVPSRTRINNPACHKTVIPNNSFVSNQIPEVEK 473

  Fly   540 RSLAANMRGMAAAPPEVPEWKKHVIGGKKSSFGKKTD--------------------------LT 578
            .|.:..........|.:.|.:.:|  ..|....|:.|                          .:
Human   474 ASESEESDEDDGPAPVIVENESYV--NLKKKISKRYDWQAKSVHAENGKICKQFRMKQASRQFQS 536

  Fly   579 LVEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTAR----GKIGCTQP 639
            ::::|||||.::.|:.::..:..:|::::.|.||.||||||.|::.:......    ..|.||||
Human   537 ILQERQSLPAWEERETILNLLRKHQVVVISGMTGCGKTTQIPQFILDDSLNGPPEKVANIICTQP 601

  Fly   640 RRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIM 704
            ||::|:|||:|||:|...|:|..|||.||.|...|..|.:.|.|.|:|||....:..|:..|.|:
Human   602 RRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDTALQGVSHII 666

  Fly   705 LDEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTFPVEVLY 769
            :||.||||..:|.|..:||..|.:||.|::|:.||||:|..||.||...|:.|||||||||:..:
Human   667 VDEVHERTEESDFLLLVLKDIVSQRPGLQVILMSATLNAELFSDYFNSCPVITIPGRTFPVDQFF 731

  Fly   770 TKEPETDYLDASLIT--VMQ------------------------------------IHLRE---- 792
            .:       ||..:|  |:|                                    :||::
Human   732 LE-------DAIAVTRYVLQDGSPYMRSMKQISKEKLKARRNRTAFEEVEEDLRLSLHLQDQDSV 789

  Fly   793 --------------------------------------------------------PPGDILLFL 801
                                                                    |||.||:||
Human   790 KDAVPDQQLDFKQLLARYKGVSKSVIKTMSIMDFEKVNLELIEALLEWIVDGKHSYPPGAILVFL 854

  Fly   802 TGQEEIDTACEILYERMKS----LGPDVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNI 862
            .|..||    ::|||:::|    ........:|.|::|:|.||.|..:|...|||..|::|:|||
Human   855 PGLAEI----KMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPAGVTKIIISTNI 915

  Fly   863 AETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTER 927
            ||||:|||.:.||:|.|.:|:|.|::..||:||..|.:|||.|.||.|||||...|..:.|:|..
Human   916 AETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSH 980

  Fly   928 AYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLLHFD-----FMDAPPVESLVMALEQLHSLSA 987
            .|..::|...:|||||..|....|::|.:.:....:..     .::.|..:||..:..:|..|.|
Human   981 HYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSAHNLQSVFSRLIEPPHTDSLRASKIRLRDLGA 1045

  Fly   988 LDDEGLLTRLGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDKQALADQK 1052
            |..:..||.||..:|..|::..:.|:::.....:|.|..|||.:.|:.::.|..|.||:..|:||
Human  1046 LTPDERLTPLGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQK 1110

  Fly  1053 KAKFNQAEGDHLTLLAVYNSWKNN-----KFSNAWCYENFVQIRTLKRSQDVRKQLL-------- 1104
            |.:|..|..|:|.||..|..|:.:     :.|..:|.:||:..|.|:....:::|..
Human  1111 KLEFAFANSDYLALLQAYKGWQLSTKEGVRASYNYCRQNFLSGRVLQEMASLKRQFTELLSDIGF 1175

  Fly  1105 ------------------GIMDRHKLDVVSAGKNSVRIQKAICSGFFRNAAK-KDPQEGYRTLVD 1150
                              |::|....:..|..:|...|...:|:..:.|..: |.|:..::....
Human  1176 AREGLRAREIEKRAQGGDGVLDATGEEANSNAENPKLISAMLCAALYPNVVQVKSPEGKFQKTST 1240

  Fly  1151 SQV------------------VYIHPSSALF---NRQPEWVIYHELVQTTKEYMRE--------- 1185
            ..|                  |:|||||..:   :....:::|||.::|::.::|:
Human  1241 GAVRMQPKSAELKFVTKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRVFIRDCSMVSVYPL 1305

  Fly  1186 -----------------VTTIDPKWLVEFAPSFFRFSDPTKLSKFKKNQRLEPLYNKYEEPN 1230
                             |.::|..| :.|..:..:.::..|..:.:.:|.|:   :|.:.|:
Human  1306 VLFGGGQVNVQLQRGEFVVSLDDGW-IRFVAASHQVAELVKELRCELDQLLQ---DKIKNPS 1363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189	19/122 (16%)
pea	NP_610928.1	HrpA	573..1221	CDD:224557	238/863 (28%)
DHX57	NP_945314.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..106		8/37 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..147		5/26 (19%)
		UBA_DHX57	181..218	CDD:270502	0/36 (0%)
		RWD	243..418	CDD:283440	36/209 (17%)
		ZnF_C3H1	303..323	CDD:214632	4/39 (10%)
		DEXDc	550..730	CDD:214692	80/179 (45%)
		DEXDc	561..703	CDD:238005	62/141 (44%)
		DEVH box	668..671		2/2 (100%)
		Helicase_C	832..968	CDD:278689	59/139 (42%)
		HA2	1043..1125	CDD:214852	28/81 (35%)
		OB_NTP_bind	1164..1310	CDD:285018	22/145 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810