Protein Alignment pea and PRP22

DIOPT Version :10

• Sequence 1: NP_610928.1
• Gene: pea / 36561
• FlyBaseID: FBgn0086895
• Length: 1242
• Species: Drosophila melanogaster
• Sequence 2: NP_010929.3
• Gene: PRP22 / 856732
• SGDID: S000000815
• Length: 1145
• Species: Saccharomyces cerevisiae
• Alignment Length: 1293
• Identity: 543/1293 - (41%)
• Similarity: 761/1293 - (58%)
• Gaps: 217/1293 - (16%)

  Fly    10 LSLVSKICTELDNHLGINDKDLAEFIIDLENKNRTYDTFRKALLDNGAEFPDSLVQNLQRIINLM 74
            :|.:||:...:   :|.:|..:.||::::.||:.....|               ::|:|::
Yeast     1 MSDISKLIGAI---VGSDDPVIIEFVLNIINKSGNLQEF---------------IRNIQKL---- 43

  Fly    75 RPSRPGGASQEKTVGDKKEDKKSQLLKMFPGLALPNDTYSKKEESDDDEKVKAKP--EKHSETHK 137
                ..|.|.|.::            ||:      |....|:||.....|||:.|  :|.::. .
Yeast    44 ----DAGISYEDSI------------KMY------NAFLGKQEEEKVRNKVKSSPLSQKINQV-L 85

  Fly   138 KTDMSDVDAAMME------------------LEALAPG-EGATLVRPHKEVSSRDRHKRRSRDRD 183
            |.|::..|..:.|                  |..:..| :..|:.:.::..|.....:..|....
Yeast    86 KDDVNLDDPVVTEFVLSILNKSKSITEFQEQLNLMQSGLDNETIFKIYQIASPPVMKEEVSVLPS 150

  Fly   184 TKRRSRSREDRHSDRRRSRSRDKERRRRSRSRDNRRRSRSREDRDRDRDRRHKSSSSRDHHERRR 248
            ||..::.......:.::..|.|
Yeast   151 TKIPAKIEAKIEEEVQKIESLD------------------------------------------- 172

  Fly   249 RSRSRSTERRDRRDRSRDCSEKMPPPSAAMTDDPEAGKIYSGKIANIVPFGCFVQLFGLR-KRWE 312
                                     ||      |...|:|.||:.||..||||||:||.| |..:
Yeast   173 -------------------------PS------PVLHKVYEGKVRNITTFGCFVQIFGTRMKNCD 206

  Fly   313 GLVHISQLRAEGRVTDVTEVVTRNQTVKVKVMSITGQ-KVSLSMKEVDQDSGKDLNPLSHAPEDD 376
            ||||||:: ::.|..|..:||.:.|.:.|:|:.|... |:|||||.:||.||:
Yeast   207 GLVHISEM-SDQRTLDPHDVVRQGQHIFVEVIKIQNNGKISLSMKNIDQHSGE------------ 258

  Fly   377 ESLRDRNPDGPFSSSTSMLNLQGNGMEGDEHESRKRVTRI-----SSPERWEIKQMISSGVLDRS 436
              :|.||.:          :::..|...|.|.||....:|     :|||||||:|:|:||.....
Yeast   259 --IRKRNTE----------SVEDRGRSNDAHTSRNMKNKIKRRALTSPERWEIRQLIASGAASID 311

  Fly   437 EMPDFDEE----TGLL------------------------PKDEDDEADIEIEIVEEEPPFLSGH 473
            :.|:..:|    |..|                        .:||.||.|:|:. .::.|.||...
Yeast   312 DYPELKDEIPINTSYLTAKRDDGSIVNGNTEKVDSKLEEQQRDETDEIDVELN-TDDGPKFLKDQ 375

  Fly   474 ---GRALHDLSPVRIVKNPDGSLAQAAMMQSALSKERREQKMLQREQEIEAMPTSLNKNWIDPLP 535
               |...:::.  :|.|.|.|.:.::|:..|...::.||:| |::::||| ......:::.||..
Yeast   376 QVKGAKKYEMP--KITKVPRGFMNRSAINGSNAIRDHREEK-LRKKREIE-QQIRKQQSFDDPTK 436

  Fly   536 -EDESRSLAANMRGMAAAPPEVPEWKKHVIGGKKSSFGKKTDLTLVEQRQSLPIYKLRDDLIKAV 599
             :.:||:....::....    |.||:|:.: .:..|:||:|.|.:..|||:||:|.:|.:||:||
Yeast   437 NKKDSRNEIQMLKNQLI----VTEWEKNRM-NESISYGKRTSLPISAQRQTLPVYAMRSELIQAV 496

  Fly   600 TDNQILIVIGETGSGKTTQITQYLGECGFTARGKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVG 664
            .|||.|:::|||||||||||||||.|.||:..|.|||||||||||:|||||||||.||::|.:||
Yeast   497 RDNQFLVIVGETGSGKTTQITQYLDEEGFSNYGMIGCTQPRRVAAVSVAKRVAEEVGCKVGHDVG 561

  Fly   665 YTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKR 729
            |||||||.|.|:|.|||||||||.||.|::.|:..|||||||||||||:.|||||.|||.|..||
Yeast   562 YTIRFEDVTGPDTRIKYMTDGMLQREALLDPEMSKYSVIMLDEAHERTVATDVLFALLKKAAIKR 626

  Fly   730 PELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTFPVEVLYTKEPETDYLDASLITVMQIHLREPP 794
            ||||:|||||||::.|||:||...||..|||:||||||||::.|:.||::|:|..|:.||:.|.|
Yeast   627 PELKVIVTSATLNSAKFSEYFLNCPIINIPGKTFPVEVLYSQTPQMDYIEAALDCVIDIHINEGP 691

  Fly   795 GDILLFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIA 859
            ||||:|||||||||:.|||||:|:|:||..:.||:|||||||||||:|::||:|.|.||||||.|
Yeast   692 GDILVFLTGQEEIDSCCEILYDRVKTLGDSIGELLILPVYSALPSEIQSKIFEPTPKGSRKVVFA 756

  Fly   860 TNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLY 924
            |||||||:|||||:|||||||.|..:||::.|::.|:|:|||||.|.||.||||||||||.||||
Yeast   757 TNIAETSITIDGIYYVVDPGFAKINIYNARAGIEQLIVSPISQAQANQRKGRAGRTGPGKCYRLY 821

  Fly   925 TERAYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPVESLVMALEQLHSLSALD 989
            ||.|:.:|||...||||||.||:.|:|.||.|||||||.|||||.||...::.||.:|:.|.:||
Yeast   822 TESAFYNEMLENTVPEIQRQNLSHTILMLKAMGINDLLKFDFMDPPPKNLMLNALTELYHLQSLD 886

  Fly   990 DEGLLTRLGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDKQALADQKKA 1054
            |||.||.||:.|:.||::|.||:.|:.||..||||||:||:||||||||||||||:|..||.|||
Yeast   887 DEGKLTNLGKEMSLFPMDPTLSRSLLSSVDNQCSDEIVTIISMLSVQNVFYRPKDRQLEADSKKA 951

  Fly  1055 KFNQAEGDHLTLLAVYNSWKNNKFSNAWCYENFVQIRTLKRSQDVRKQLLGIMDRHKLDVVSAGK 1119
            ||:...|||||||.||..|:...:|..:|..||:..|.|||::||:.|:..|..:..|.::|...
Yeast   952 KFHHPYGDHLTLLNVYTRWQQANYSEQYCKTNFLHFRHLKRARDVKSQISMIFKKIGLKLISCHS 1016

  Fly  1120 NSVRIQKAICSGFFRNAAKKDPQEGYRTLVDSQVVYIHPSSALFNRQPEWVIYHELVQTTKEYMR 1184
            :...|:|...||||.||||:|.|.||:|:.....|.|||||:|:.::.|:|:||.:|.|::|||.
Yeast  1017 DPDLIRKTFVSGFFMNAAKRDSQVGYKTINGGTEVGIHPSSSLYGKEYEYVMYHSIVLTSREYMS 1081

  Fly  1185 EVTTIDPKWLVEFAPSFFRFSDPTKLSKFKKNQRLEPLYNKY-EEPNAWRISRVRRRR 1241
            :||:|:|:||:|.||.|::..|..  |:.:|..::.||:||: ::.|:||:|.:|:.|
Yeast  1082 QVTSIEPQWLLEVAPHFYKAGDAE--SQSRKKAKIIPLHNKFAKDQNSWRLSSIRQSR 1137

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	GH2-like_DHX8	7..74	CDD:409668	12/63 (19%)
		S1_DHX8_helicase	285..363	CDD:240189	38/79 (48%)
		HrpA	578..>1203	CDD:441249	388/624 (62%)
PRP22	NP_010929.3	GH2_like	<12..58	CDD:425380	14/86 (16%)
		GH2_like	75..136	CDD:409667	9/61 (15%)
		S1_DHX8_helicase	178..257	CDD:240189	38/79 (48%)
		HrpA	483..>1097	CDD:441249	383/613 (62%)