DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and PRP43

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_011395.1	Gene:	PRP43 / 852757	SGDID:	S000003088	Length:	767	Species:	Saccharomyces cerevisiae

Alignment Length:	780	Identity:	368/780 - (47%)
Similarity:	514/780 - (65%)	Gaps:	75/780 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   495 QAAMMQSALSKERREQKMLQREQEIEAMPTSLNKNWIDPLPEDES--RSLAANMRGMAAAPPEVP 557
            |||.:...|||:.                         |||.:|.  ...|...:|:........
Yeast    22 QAAEIAEELSKQH-------------------------PLPSEEPLVHHDAGEFKGLQRHHTSAE 61

  Fly   558 EWKKHVIGGKKSSF-GKKTD---LTLVEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQ 618
            |.:| :..||.:.| |::..   :.:::.|:.||::..||:.:|...:|||::.:||||||||||
Yeast    62 EAQK-LEDGKINPFTGREFTPKYVDILKIRRELPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQ 125

  Fly   619 ITQYL--GECGFTARGKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKY 681
            |.|::  .|.......::.|||||||||||||:|||||...:||:||||:||||:.||.:||:||
Yeast   126 IPQFVLFDEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEVGYSIRFENKTSNKTILKY 190

  Fly   682 MTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKF 746
            |||||||||.:.:.:|..||.|:||||||||:.||:|.||||..|::||:||:|:.||||||.||
Yeast   191 MTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSATLDAEKF 255

  Fly   747 SQYFFKAPIFTIPGRTFPVEVLYTKEPETDYLDASLITVMQIHLREPPGDILLFLTGQEEIDTAC 811
            .:||..||:..:||||:|||:.||.|.:.||||:::.||:|||..|..|||||||||::||:.|.
Yeast   256 QRYFNDAPLLAVPGRTYPVELYYTPEFQRDYLDSAIRTVLQIHATEEAGDILLFLTGEDEIEDAV 320

  Fly   812 -EILYE-----RMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPAG-----SRKVVIATNIAET 865
             :|..|     |.:..||    |.:.|:|.:||...|.|||:|||..     .|||||:||||||
Yeast   321 RKISLEGDQLVREEGCGP----LSVYPLYGSLPPHQQQRIFEPAPESHNGRPGRKVVISTNIAET 381

  Fly   866 SLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYR 930
            |||||||.|||||||.||||||.:..::||:|:|||:|:|:|||||||||.|||.:|||||.|::
Yeast   382 SLTIDGIVYVVDPGFSKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFQ 446

  Fly   931 DEMLPTPVPEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPVESLVMALEQLHSLSALDDEGLLT 995
            .|::....|||.|:||::|||:||.:||:||:||||||.|..|:::.|||:|:.|:.|||||.||
Yeast   447 KELIEQSYPEILRSNLSSTVLELKKLGIDDLVHFDFMDPPAPETMMRALEELNYLACLDDEGNLT 511

  Fly   996 RLGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRP-KDKQALADQKKAKFNQA 1059
            .|||..::|||:|.|:.|||.|...|||.||||||:||||.|||.|| |||:. ||..|..|...
Yeast   512 PLGRLASQFPLDPMLAVMLIGSFEFQCSQEILTIVAMLSVPNVFIRPTKDKKR-ADDAKNIFAHP 575

  Fly  1060 EGDHLTLLAVYNSWKNNKF----SNAWCYENFVQIRTLKRSQDVRKQLLGIMDRHKLDVVSAGKN 1120
            :|||:|||.||:::|:::.    .:.||.::::..|:|..:.::|.||..:|:|:.|::.:....
Yeast   576 DGDHITLLNVYHAFKSDEAYEYGIHKWCRDHYLNYRSLSAADNIRSQLERLMNRYNLELNTTDYE 640

  Fly  1121 SVR----IQKAICSGFFRNAAKK-DPQEGYRTLVDSQVVYIHPSSALFNRQPEWVIYHELVQTTK 1180
            |.:    |:||:.||||...||| ...:||.|:.|:|.|.||||:.| ....|||||:|.|.|:|
Yeast   641 SPKYFDNIRKALASGFFMQVAKKRSGAKGYITVKDNQDVLIHPSTVL-GHDAEWVIYNEFVLTSK 704

  Fly  1181 EYMREVTTIDPKWLVEFAPSFFRFSDPTKLSKFKKNQ---RLEPLYNKYEEPNAWRISRVRRRRN 1242
            .|:|.||::.|:||:|.||:::      .||.|:|..   .||.:..|.:     |::.:::.:|
Yeast   705 NYIRTVTSVRPEWLIEIAPAYY------DLSNFQKGDVKLSLERIKEKVD-----RLNELKQGKN 758

Fly 1243 1242
Yeast 759 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	346/676 (51%)
PRP43	NP_011395.1	HrpA	55..753	CDD:224557	355/715 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
TreeFam	0	0.000	Not matched by this tool.
	6	5.720