Protein Alignment pea and DHX16

DIOPT Version :10

• Sequence 1: NP_610928.1
• Gene: pea / 36561
• FlyBaseID: FBgn0086895
• Length: 1242
• Species: Drosophila melanogaster
• Sequence 2: NP_003578.2
• Gene: DHX16 / 8449
• HGNCID: 2739
• Length: 1041
• Species: Homo sapiens
• Alignment Length: 1228
• Identity: 469/1228 - (38%)
• Similarity: 674/1228 - (54%)
• Gaps: 234/1228 - (19%)

  Fly    19 ELDNHLGINDKDLAEFIIDLENKNRTYDTFRKALLDNGAEFPDSLVQNLQRIINLMRPSR----- 78
            ||.:.||::::.:|:|:|....:..:.:.|.:.|.|.     |:|        :|..|:|
Human    14 ELHSVLGLSERHVAQFLIGTAQRCTSAEEFVQRLRDT-----DTL--------DLSGPARDFALR 65

  Fly    79 -----PGGASQEKTVGDKKEDKKSQLLKMFPGLALPNDTYSKKEESDDDEK---------VKAKP 129
                 |..|..||.....:.:.::.|.|        |.:|...|:|::..:         ::.|.
Human    66 LWNKVPRKAVVEKPARAAEREARALLEK--------NRSYRLLEDSEESSEETVSRAGSSLQKKR 122

  Fly   130 EKHSETHKKTDMSDVDAAMMELEALAPGEGATLVRPHKEVSSRDRHKRRSRDRDTKRRSRSREDR 194
            :|.....||.:..:.:.|..:.:....|......:|..|    |..:|..|:     |.:..|:|
Human   123 KKRKHLRKKREEEEEEEASEKGKKKTGGSKQQTEKPESE----DEWERTERE-----RLQDLEER 178

  Fly   195 HSDRRRSRSRDKERRRRSRSRDNRRRSRSREDRDRDRDRRHKSSSSRDHHERRRRSRSRSTERRD 259
            .:...|.|.|||:|.|....|.:::.....:.|.:..:...|:...    |.|::||.....:|:
Human   179 DAFAERVRQRDKDRTRNVLERSDKKAYEEAQKRLKMAEEDRKAMVP----ELRKKSRREYLAKRE 239

  Fly   260 RRDRSRDCSEKMPPPSAAMTDDPEAGKIYSGKIANIVPFGCFVQLFGLRKRWEGLVHISQLRAEG 324
            |        ||:....|.:.|:.                    .|||
Human   240 R--------EKLEDLEAELADEE--------------------FLFG------------------ 258

  Fly   325 RVTDVTEVVTRNQTVKVKVMSITGQKVSLSMKEVDQDSGKDLNPLSHAPEDDESLRDRNPDGPFS 389
               ||.......|.:|.|      ::|            :||.....|..:.|.|...|
Human   259 ---DVELSRHERQELKYK------RRV------------RDLAREYRAAGEQEKLEATN------ 296

  Fly   390 SSTSMLNLQGNGMEGDEHESRKRVTRISSPERWEIKQMISSGVLDRSEMPDFDEETGLLPKDEDD 454
                                           |:.                        :||:...
Human   297 -------------------------------RYH------------------------MPKETRG 306

  Fly   455 EADIEIEIVEEEPPFLSG-HGRALHDLSPVRIVKNPDGSLAQAAMMQSALSKERREQKMLQREQE 518
            :....:::||||    || .|.........|:     |:.:.....:.|.|:|.:.|.:|:.|:.
Human   307 QPARAVDLVEEE----SGAPGEEQRRWEEARL-----GAASLKFGARDAASQEPKYQLVLEEEET 362

  Fly   519 IEAMPTSLNKNWIDPLPEDESRSLAANMRGMAAAPPEVPEWKKHVIGGKKSSFGKKTDLTLVEQR 583
            ||.:..:       .|..||..|          |||            ..:...:|..:..|  |
Human   363 IEFVRAT-------QLQGDEEPS----------APP------------TSTQAQQKESIQAV--R 396

  Fly   584 QSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTARG-KIGCTQPRRVAAMSV 647
            :|||::..|::|:.|:.::|:||:.|||||||||||.|||.|.|:|.:| ||.||||||||||||
Human   397 RSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRRVAAMSV 461

  Fly   648 AKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERT 712
            |.|||.|.|.:||.||||:||||||||..|:::||||||||||.|.|.:|.||||:|:|||||||
Human   462 AARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERT 526

  Fly   713 IHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTFPVEVLYTKEPETDY 777
            :|||:||||:|...:.|||||::|.|||:|..:||.:|..||:|.||||.|||::.|||.||.||
Human   527 LHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPVFRIPGRRFPVDIFYTKAPEADY 591

  Fly   778 LDASLITVMQIHLREPPGDILLFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQ 842
            |:|.:::|:|||:.:||||||:||||||||:.|||:|.:|.:.||..:.||::||:|:.|||:||
Human   592 LEACVVSVLQIHVTQPPGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQ 656

  Fly   843 TRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQ 907
            .|||.|.|.|:||||:|||||||||||:||.||:||||.|||.||.:|||:||.|||.|:|:|.|
Human   657 ARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQ 721

  Fly   908 RAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPV 972
            |||||||...||.:||||..||:.|:..|.|||||||:|...||.||::||:||:||||:|.||.
Human   722 RAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPY 786

  Fly   973 ESLVMALEQLHSLSALDDEGLLTRLGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQN 1037
            |:|::|||||::|.||:..|.||..||:|||.|::|.||||::.|....||:||||:.:||||.|
Human   787 ETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNN 851

  Fly  1038 -VFYRPKDKQALADQKKAKFNQAEGDHLTLLAVYNSWKNNKFSNAWCYENFVQIRTLKRSQDVRK 1101
             :|||||||...||..:..|....||||.||.||..|..:.:|:.||||||||.|:::|::|||:
Human   852 SIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVRE 916

  Fly  1102 QLLGIMDRHKLDVVSAGKNSVRIQKAICSGFFRNAAKKDPQEGYRTLVDSQVVYIHPSSALFNRQ 1166
            ||.|:::|.::.:.|...:.:|::|||.:|:|.:.|:. .:.||||:...|.|:|||:|:||.:|
Human   917 QLEGLLERVEVGLSSCQGDYIRVRKAITAGYFYHTARL-TRSGYRTVKQQQTVFIHPNSSLFEQQ 980

  Fly  1167 PEWVIYHELVQTTKEYMREVTTIDPKWLVEFAPSFFRFSD---------PTKLSKFKK 1215
            |.|::|||||.||||:||:|..|:..||:|.||.:::..:         |.|:.|.::
Human   981 PRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYKAKELEDPHAKKMPKKIGKTRE 1038

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	GH2-like_DHX8	7..74	CDD:409668	12/54 (22%)
		S1_DHX8_helicase	285..363	CDD:240189	9/77 (12%)
		HrpA	578..>1203	CDD:441249	364/626 (58%)
DHX16	NP_003578.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..207		24/114 (21%)
		PTZ00121	<148..376	CDD:173412	66/384 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	371..391		8/41 (20%)
		HrpA	398..>1025	CDD:441249	362/627 (58%)
		DEAH box	520..523		2/2 (100%)