DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pea and DHX40

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_078888.4	Gene:	DHX40 / 79665	HGNCID:	18018	Length:	779	Species:	Homo sapiens

Alignment Length:	693	Identity:	296/693 - (42%)
Similarity:	419/693 - (60%)	Gaps:	68/693 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   585 SLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTARGKIGCTQPRRVAAMSVAK 649
            :.||.|.|..:|:||.||..|||.|.||||||||:.:||.|.||:..|.||.||||:|||:|||:
Human    52 TFPIQKQRKKIIQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMIGVTQPRKVAAISVAQ 116

  Fly   650 RVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIH 714
            |||||..|.||.:|||.:||:||:|.||.|||||||.||:..|.:..|..:|||:||||||||:.
Human   117 RVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLT 181

  Fly   715 TDVLFGLLKTAVQ-----KRPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTFPVEVLYTK--- 771
            ||:||||||...|     ::..||::|.|||::..|.|.:|...|||.||||.:||...:..
Human   182 TDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIG 246

  Fly   772 ---EPETDYLDASLITVMQIHLREPPGDILLFLTGQEEIDTACEILYERMKSLGPD-------VP 826
               ...|.|:.|.:...|.|||.|..||||:|||||.||:.:||:|::..:|:..|       :.
Human   247 PRDRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLD 311

  Fly   827 ELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTG 891
            .|:|||.|.::.::.|.|||.|.|.|.||.||:|||:.||||||||.||||.|||||..:|.:.|
Human   312 GLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLG 376

  Fly   892 MDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTM 956
            :|.|.|.|||::.|.||:||||||..||.:|:|::..:...|....:|||:||:|.:.||.||.:
Human   377 LDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCL 441

  Fly   957 GINDLLHFDFMDAPPVESLVM-ALEQLHSLSALDDEGLLTRLGRRMAEFPLEPNLSKMLIMSVAL 1020
            .|:|::.|.::| ||.|.|:: ||:||:...|:|..|.:||||..|.||||.|:|:..:|.:.:|
Human   442 AIHDVIRFPYLD-PPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASL 505

  Fly  1021 QCSDEILTIVSMLSVQNVFYRPKDKQALADQKKAKFNQAE--------GDHLTLLAVYNSWKNNK 1077
            .|.|.:|.|.:||||:|||.||.|.:.   ||:|:....|        .|..||..::...|::.
Human   506 DCEDLLLPIAAMLSVENVFIRPVDPEY---QKEAEQRHRELAAKAGGFNDFATLAVIFEQCKSSG 567

  Fly  1078 FSNAWCYENFVQIRTLKRSQDVRKQLLGIMDRHK------LDVVSAGKNSVRIQKAICSGFFRNA 1136
            ...:||.::::..|.|..:..|..||..::.:.|      .:.....|:.| :::.:|:|:|:|.
Human   568 APASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPKETFEGPKHEV-LRRCLCAGYFKNV 631

  Fly  1137 AKKDPQEGYRTLVDSQ--VVYIHPSSALFNRQP--EWVIYHELVQTTKEYMREVTTIDPKWLVEF 1197
            |::.....:.|: |.:  .|:|||||||..::.  ||:|:||::.|||.|.|.|..|..:|:.:.
Human   632 ARRSVGRTFCTM-DGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDL 695

  Fly  1198 APSFFRFSDPTKLSKFKKNQRLEPLYNKYEEPNAWRISRVRRR 1240
            .|         ||.:|                ||..:|.|.||
Human   696 LP---------KLHEF----------------NAHDLSSVARR 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	290/672 (43%)
DHX40	NP_078888.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		HrpA	16..770	CDD:224557	296/693 (43%)
		DEAH box	173..176		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..779
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820