DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and dhx33

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_001093527.3	Gene:	dhx33 / 796505	ZFINID:	ZDB-GENE-131127-77	Length:	680	Species:	Danio rerio

Alignment Length:	669	Identity:	311/669 - (46%)
Similarity:	426/669 - (63%)	Gaps:	20/669 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   554 PEVPEWKKHVIGGKKSSFGKKTDLTL---------VE-QRQSLPIYKLRDDLIKAVTDNQILIVI 608
            |:.|..|:...|.......||..:.|         || ||:.||||:.|..:|..:......:.|
Zfish     5 PDPPPAKRFKPGSPFFRLDKKPGMLLPRAGHAAAGVEAQRRHLPIYQSRTQVISQLRQLHSAVFI 69

  Fly   609 GETGSGKTTQITQYLGECGFTARGKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCT 673
            |||||||||||.|||.|.|...:|.|..||||||||:|:|.|||||...:||:.||||:||||.|
Zfish    70 GETGSGKTTQIPQYLYEAGIGRQGIIAITQPRRVAAISLAGRVAEEKKVQLGKLVGYTVRFEDVT 134

  Fly   674 SPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPE-----LK 733
            ||||.:|:|||||||||.:.:..|..|:|::||||||||:|||||||::|.|.::|.|     ||
Zfish   135 SPETKLKFMTDGMLLREAIGDPLLLRYTVVILDEAHERTVHTDVLFGVVKAAQRRRLEQNKIPLK 199

  Fly   734 LIVTSATLDAVKFSQYFFKAPIFTIPGRTFPVEVLYTKEPETDYLDASLITVMQIHLREPPG-DI 797
            ::|.|||:|...|||||.|:|:..:.||..|:::.|||:|::|||.|:|:::.|||...|.. ||
Zfish   200 VVVMSATMDVDLFSQYFNKSPVLYLEGRQHPIQIYYTKQPQSDYLQAALVSIFQIHQEAPSSHDI 264

  Fly   798 LLFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNI 862
            |:||||||||:.......:..|.|......:.::|:|::||...|.|:|.|||.|||||:::|||
Zfish   265 LVFLTGQEEIEALARTCRDISKHLPDTSGSMTVVPLYASLPPAQQMRVFLPAPKGSRKVILSTNI 329

  Fly   863 AETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTER 927
            ||||:||.||.||:|.|.||.|.:|..:|::.|.|..:|:|.|.||||||||...|..||||||.
Zfish   330 AETSITISGIKYVIDTGMVKAKRFNPDSGLEVLAVQRVSKAQAWQRAGRAGREDAGSCYRLYTED 394

  Fly   928 AYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPVESLVMALEQLHSLSAL---D 989
            .: :.:....||||||.|||:.||||..:|:.|:|:|||:..|..||:..|:|||..|.|:   |
Zfish   395 EF-ENLANMTVPEIQRCNLASVVLQLLALGVPDVLNFDFVSKPSPESMRTAVEQLCILGAVDRKD 458

  Fly   990 DEGLLTRLGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDKQALADQKKA 1054
            |...||.||::||.|||||..||.|::|....|::|||||:|:|||.:|.|.|..::......:.
Zfish   459 DHVSLTPLGKKMACFPLEPRFSKTLLISPDFSCTEEILTIISLLSVDSVLYNPPARRDEVISVRK 523

  Fly  1055 KFNQAEGDHLTLLAVYNSWKNNKFSNAWCYENFVQIRTLKRSQDVRKQLLGIMDRHKLDVVSAGK 1119
            ||..:||||:|||.:|.::|....:..||.||||..|.:....:||.||..|..:..|.:.|:..
Zfish   524 KFISSEGDHITLLNIYRAFKKVSGNKDWCRENFVNSRNMGLVGEVRAQLRDICIKMNLKLESSVC 588

  Fly  1120 NSVRIQKAICSGFFRNAAKKDPQEGYRTLVDSQVVYIHPSSALFNRQPEWVIYHELVQTTKEYMR 1184
            :...:::.:..|.|.:||:..|...|..|...|.|.|||||.||..:|..|:::||:.|::.|||
Zfish   589 DLANVRRCLAHGLFMSAAELQPDGSYVALDTHQPVSIHPSSVLFQARPVCVLFNELLHTSRCYMR 653

  Fly  1185 EVTTIDPKWLVEFAPSFFR 1203
            ::..|...||.|.||.:||
Zfish   654 DLCLIQTDWLHEAAPEYFR 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	307/650 (47%)
dhx33	NP_001093527.3	DEXDc	50..234	CDD:214692	101/183 (55%)
		DEXDc	64..207	CDD:238005	86/142 (61%)
		Helicase_C	264..381	CDD:278689	58/116 (50%)
		HA2	451..536	CDD:214852	39/84 (46%)
		OB_NTP_bind	570..670	CDD:285018	35/99 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.730