Protein Alignment pea and ythdc2

DIOPT Version :10

• Sequence 1: NP_610928.1
• Gene: pea / 36561
• FlyBaseID: FBgn0086895
• Length: 1242
• Species: Drosophila melanogaster
• Sequence 2: XP_004910524.1
• Gene: ythdc2 / 779469
• XenbaseID: XB-GENE-5881731
• Length: 1457
• Species: Xenopus tropicalis
• Alignment Length: 1176
• Identity: 294/1176 - (25%)
• Similarity: 468/1176 - (39%)
• Gaps: 386/1176 - (32%)

  Fly   355 MKEVDQDSGKDLNPLSHAPEDD--ESLRDRNPDGPFSSSTSMLNLQGNGMEGDEHESRKRVTRIS 417
            |:.....|...|:..:..|.|:  .|.::....||                   ||...|..  |
 Frog     1 MRRTGAISVSHLDTRAQRPADNGSRSRKEARETGP-------------------HEKMSRPN--S 44

  Fly   418 SPERWEIKQMISSGVLDRSEMPDFDEETGLLPKDEDDEADIEIEIVEEE-----------PPFLS 471
            :..|..:.:..|.....||:        ||.....|:|..|.:.|..|:           |..|:
 Frog    45 TSPRPNVVKKPSPANPGRSK--------GLKDIRIDEEVKIAVNIALEKFRYSDQKEMEFPSSLT 101

  Fly   472 GHGRA-LHDLS-------------PVR--IVKNPDGSLAQAAMMQSALSKERREQ--KMLQREQE 518
            ...|| :|.|:             |.|  .:|..:||.|.:::|...|::..::.  .::||
 Frog   102 STERAFIHRLAQSLGLVSKSKGKGPNRCLTLKKKNGSEASSSLMSCTLTQNTKKAVCNLIQR--- 163

  Fly   519 IEAMPTSLNKNWIDPLP----------EDESRSLAANMRGMAAAPPEVPEWKKHVIGGKKSSFGK 573
               .|.: ||...:.||          |.|:|.:......:....|:||:.:    |..|..|
 Frog   164 ---FPLT-NKERTELLPKTERGNVYAIEAENREIGKTSGCLNGGIPQVPDKR----GESKYDF-- 218

  Fly   574 KTDLTLVEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQY-LGEC---GFTARGKI 634
                    .|||||:::.::|:|:.:.:|::::::|||||||||||.|: |..|   |...|  |
 Frog   219 --------FRQSLPVFEKQEDIIRIIKNNKVVLIVGETGSGKTTQIPQFILDNCQKNGLPCR--I 273

  Fly   635 GCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLM--EAEL 697
            .||||||:||:|||:|||.|.|..:||.|||.||.|...||:|::.:.|:|:||| .||  ::.|
 Frog   274 FCTQPRRLAAISVAERVAAERGEIIGQCVGYQIRLESRVSPKTLLTFCTNGVLLR-TLMGGDSTL 337

  Fly   698 KSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRT 762
            .:.:.|::||.|||...:|.|...|:.|:|:.|.||||::||.||...|.:||...|:..|.||.
 Frog   338 SAITHIIVDEVHERDRFSDFLLTKLRDAIQEHPTLKLILSSAALDVNLFIRYFGGCPVIYIQGRP 402

  Fly   763 FPVEVL------------------YTKE-----------------------PET----------- 775
            |.|:.:                  |.||                       |||
 Frog   403 FEVKEMFLEDILRSTGYRNKGMLKYNKEKQCEEKQKTTLTEWYSAKQKNMKPETQRQRSVPAIKE 467

  Fly   776 --DYLD----------------------------------------------------------- 779
              |.||
 Frog   468 EYDILDDGGDTAFGQMTEKDANCLEPWLIKEIDACLSDIWLYRDKDAFAQLFHLISTENVSVDYR 532

  Fly   780 -------------------------------------------------------------ASLI 783
                                                                         |||.
 Frog   533 HSETSATPLMVAAGQGFLSHVEQLISMGANIQSKASNGWMALDWAKHFGQTEVVDLLESYSASLE 597

  Fly   784 TV--------------MQIHLRE------------------------------PPGDILLFLTGQ 804
            |.              :.|..||                              ..|.||:||.|.
 Frog   598 TEDLDENTLVQSDGNDLSIEDRELLKAYHHSFDDEKVDLDLIMHVLFNICQITDTGAILIFLPGY 662

  Fly   805 EEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTI 869
            :||....:.:....|....:.....:..::|.:.:..|.::....|||.||::::|||||||:|:
 Frog   663 DEIVGLRDRILLDDKRFADNAQRYHVFMLHSNMQTSDQKKVLKLPPAGIRKIILSTNIAETSITV 727

  Fly   870 DGIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEML 934
            :.:.:|:|.|.||:|.:::...:..|.:..||:|:|.||.|||||..||..:||:::..::: ||
 Frog   728 NDVVFVIDSGKVKEKSFDALNNVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSKLRFQN-ML 791

  Fly   935 PTPVPEIQRTNLATTVLQLKTM-----GINDLLHFDFMDAP-PVESLVM--ALEQLHSLSALDDE 991
            ....||:.|..|....|..|.:     .:.|.|    |.|| |..:|::  |::.|.::.|:|:.
 Frog   792 EFQTPELLRIPLHELCLHTKLLVPINCPVADFL----MKAPEPPPALIVRNAVQMLKTIDAMDNW 852

  Fly   992 GLLTRLGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDKQALADQKKA-- 1054
            ..||.:|..:|:.|:||:|.||::.:|.|:|.|.||||...|:.::.|..|..    |.||:|
 Frog   853 EDLTEIGHHLADLPVEPHLGKMVLCAVILKCLDPILTIACTLAYRDPFVLPSQ----ASQKRAAM 913

  Fly  1055 ----KFNQAE-GDHLTLLAVYNSW---KNNKFSNAWCYENFVQIRTLKRSQDVRKQLLG------ 1105
                :|.... .||:.||..:.:|   |::.:..|:|.:||:...|::....:|.||||
 Frog   914 LCRKRFTAGTFSDHMALLRAFQAWQKAKSDGWERAFCEKNFLSQATMEIIIGLRTQLLGQLRASG 978

  Fly  1106 -IMDRHKLDVVSAGKNSVR---IQKAICSGFFRNAAKKDPQEGYRTLVDSQVVYIHPSSALFNRQ 1166
             :..|...|:.....||..   ::.|:.||.:.|....|.:....:.|..:.|..||||||...|
 Frog   979 FVRARGGGDIRDVNINSENWAVVKAALLSGMYPNLIHVDRENMVLSGVKEKRVRFHPSSALSEPQ 1043

  Fly  1167 ------------------PEWVIYHELVQTTK-EYMREVTTIDPKWLVEFA------------PS 1200
                              .:|::|.|:.::.: ..::..:.:.|...|.||            ||
 Frog  1044 YKKIPSANCQAEAVQALPTDWLVYDEMTRSHRIANIKCCSVVTPVTAVLFAGPARLPSSALKEPS 1108

  Fly  1201 FFRFSD 1206
            .|:..|
 Frog  1109 SFQVGD 1114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	GH2-like_DHX8	7..74	CDD:409668
		S1_DHX8_helicase	285..363	CDD:240189	1/7 (14%)
		HrpA	578..>1203	CDD:441249	239/907 (26%)
ythdc2	XP_004910524.1	DEXHc_YTHDC2	223..398	CDD:350745	81/177 (46%)
		ANK repeat	535..567	CDD:293786	0/31 (0%)
		ANKYR	<539..>606	CDD:440430	4/66 (6%)
		ANK repeat	569..600	CDD:293786	4/30 (13%)
		OB_NTP_bind	1001..1096	CDD:400182	21/94 (22%)
		YTH	1317..1446	CDD:410979
		R3H_DEXH_helicase	76..134	CDD:100077	11/57 (19%)
		HrpA	222..>1040	CDD:441249	226/829 (27%)