Protein Alignment pea and Dhx30

DIOPT Version :10

• Sequence 1: NP_610928.1
• Gene: pea / 36561
• FlyBaseID: FBgn0086895
• Length: 1242
• Species: Drosophila melanogaster
• Sequence 2: NP_001239612.1
• Gene: Dhx30 / 72831
• MGIID: 1920081
• Length: 1223
• Species: Mus musculus
• Alignment Length: 1276
• Identity: 322/1276 - (25%)
• Similarity: 522/1276 - (40%)
• Gaps: 329/1276 - (25%)

  Fly    59 FPDSLV-----QNLQRIINLMRPSRPGGASQEKTVGDKKEDKKSQ-LLKMFP----------GLA 107
            |..|.|     |....:.:.:.||.||       .||......|: |||.||          |.|
Mouse    36 FSSSFVRSDGTQEAAEVESEVAPSEPG-------EGDGSMVNASRDLLKEFPQPKNLLNSVIGRA 93

  Fly   108 LPNDTYSKKEESDDDEKV--------KAKPEKHSETHKKTDMSDVDAAMMELEALAPG------E 158
            | ..:::|      |:.|        |.|...|.:..|..::....:..::.|..|..      :
Mouse    94 L-GISHAK------DKLVYVHTNGPKKKKVTLHIKWPKSVEVEGYGSKKIDAERQAAAAACQLFK 151

  Fly   159 GATLVRPHKEVSSRDRHKRRSRDRDTKRRSRSREDRHSDRRRSRSRDKERRR----RSRSRDNRR 219
            |..|:.|..|:....::             |...||......|..|.:....    |..:.:|.|
Mouse   152 GWGLLGPRNELFDAAKY-------------RVLADRFGSPADSWWRPEPTMPPTSWRQLNPENIR 203

  Fly   220 --------RSRSREDRDRDRDRRHK---------SSSSRDHHERRRRSRSRSTERRDRRDRSRDC 267
                    ||..||:.:.:.:...:         |.:.:|.|...|.||..|.|..|.....|..
Mouse   204 PGGPAGLSRSLGREEEEDEEEELEEGTIDVTEFLSMTQQDSHNPLRDSRGGSFEMTDDDSAIRAL 268

  Fly   268 SEKMPPPSAAMTDDPEAGKIY-----SGKIANIVPF---GCFVQLFGLRKRWE-GLVHISQLRAE 323
            :: .|.|...:      .|:.     |....|::.|   |...:|..|...|. .:..:    |:
Mouse   269 TQ-FPLPKNLL------AKVIQIATSSSTAKNLMQFHTVGTKTKLATLTLLWPCPMTFV----AK 322

  Fly   324 GRVTDVTEVVTRNQTVKVKVMSITGQKVSLSMKEVDQDSGKDLNPLSHAPEDDESLRDRNPDGPF 388
            ||         |....:.|..::..:|:. |:..||:::    .||:||..:..|||:..
Mouse   323 GR---------RKAEAENKAAALACKKLK-SLGLVDRNN----EPLTHAMYNLASLRELG----- 368

  Fly   389 SSSTSMLNLQGNGMEGDEHESRKRVTRISSPE--RWEIKQMISSGVLDRSEM-PDFD-EETGLLP 449
                               |:::|...|..||  ..:|:..:|...:|.|.: |:.. :...:||
Mouse   369 -------------------ETQRRPCTIQVPEPILRKIEAFLSHYPVDSSWISPELRLQSDDILP 414

  Fly   450 --KDEDDEADIEIEIVEEEPPFLSGHGRALHDLSPVRIVKNPDGSLAQAAMMQSALSKERREQKM 512
              ||....:|          |..   |:....||....|:          :.||.|...||
Mouse   415 LGKDSGPLSD----------PIT---GKPYMPLSEAEEVR----------LSQSLLELWRR---- 452

  Fly   513 LQREQEIEAMPTSLNKNWIDPLPEDESRSLAANMRGMAAAPPEVPEWKKHVIGGKKSSFGKKTDL 577
                                              ||        |.|
Mouse   453 ----------------------------------RG--------PIW------------------ 457

  Fly   578 TLVEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGEC----GFTARGKIGCTQ 638
               ::...||:...||.::.|:..:.::::.|:||.||||:|.|.|.|.    |..||..:..||
Mouse   458 ---QEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQ 519

  Fly   639 PRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPET---IIKYMTDGMLLRECLMEAELKSY 700
            |||::|:|||:||:.|.|..|.:.||:.:|.|  :.|..   .:.:.|.|:|||:......|:..
Mouse   520 PRRISAVSVAQRVSHELGPSLRRNVGFQVRLE--SKPPARGGALLFCTVGILLRKLQSNPSLEGV 582

  Fly   701 SVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTFPV 765
            |.:::||.|||.::||.|..|||...:..|.|:|::.|||.|..:||:||...|:..:||..:||
Mouse   583 SHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPV 647

  Fly   766 EVLYTK------------------EPETD-YLDASLITVMQIHL--REPPGDILLFLTGQEEIDT 809
            :..|.:                  |.|.: .||..|:|.:.:|:  |..||.||.||.|.:||..
Mouse   648 KEHYLEDILAKLGKHQYPHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKG 712

  Fly   810 ACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFY 874
            ..:.|.|   :||....:.:||||:|.:|...|..||...|.|.||:|:||||||||:|::.|.:
Mouse   713 VQQRLQE---ALGMHESKYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVH 774

  Fly   875 VVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVP 939
            |||.|..|::.|:.||.:..|....:|:|...||.|||||...|..|.|: .|:..::|:|..||
Mouse   775 VVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLF-PRSRLEKMVPFQVP 838

  Fly   940 EIQRTNLATTVLQLKTMGINDLLHF------DFM----DAPPVESLVMALEQLHSLSALDDEGLL 994
            ||.||.|...|||.|       :|.      :|:    |:|.::::..|:..|..:..||....|
Mouse   839 EILRTPLENLVLQAK-------IHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYL 896

  Fly   995 TRLGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDKQALADQKKAKFNQA 1059
            |.||:|:|....:|.|:|.::::...:|...:|.:||.|: ::.|......:|..|:.||..:..
Mouse   897 TTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQNRAEVDKVKALLSHD 960

  Fly  1060 EG-DHLTLLAVYNSWKN-NKFSNAWCYENFVQIRTLKRSQDVRKQLLGIMDRHKLDVVSA---GK 1119
            .| |||..:.....|:. .::.:....||::: ..|..:..:| .:.|::.:...::..|   ||
Mouse   961 SGSDHLAFVRAVAGWEEVLRWQDRTSRENYLE-ENLLYAPSLR-FIHGLIKQFSENIYEAFLVGK 1023

  Fly  1120 NS-VRIQKAIC---------------SGFFRNAAK----KDPQEG--------YRTLVDSQVVYI 1156
            .| ..:..|.|               :|.:.|..:    |..::|        |||  .|..:.:
Mouse  1024 PSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVTYRT--KSGNILL 1086

  Fly  1157 HPSSALFNRQ-----PEWVIYHELVQTT-KEYMREVTTIDP 1191
            |.|:  .||:     ..|:.|...|::. ..::|:.:.:.|
Mouse  1087 HKST--INREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHP 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	GH2-like_DHX8	7..74	CDD:409668	4/19 (21%)
		S1_DHX8_helicase	285..363	CDD:240189	17/86 (20%)
		HrpA	578..>1203	CDD:441249	213/691 (31%)
Dhx30	NP_001239612.1	HrpA	455..>987	CDD:441249	187/566 (33%)
		OB_NTP_bind	1044..1131	CDD:400182	17/86 (20%)