DRSC/TRiP Functional Genomics Resources

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Protein Alignment pea and Dhx36

DIOPT Version :9

Sequence 1:NP_610928.1 Gene:pea / 36561 FlyBaseID:FBgn0086895 Length:1242 Species:Drosophila melanogaster
Sequence 2:NP_082412.2 Gene:Dhx36 / 72162 MGIID:1919412 Length:1001 Species:Mus musculus


Alignment Length:918 Identity:273/918 - (29%)
Similarity:431/918 - (46%) Gaps:181/918 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   487 KNPDGSLAQAAMMQSALSKERREQKMLQREQEIEA---MPTSLNKNWIDPLPEDESRSLAANMRG 548
            ||.:....:.|::.   ..||||::::|....::|   ..:....:|.  .|||.......:...
Mouse    66 KNKEAERQERAVVH---MDERREEQIVQLLNSVQAKTDKDSEAQISWF--APEDHGYGTEVSSEK 125

  Fly   549 MAAAPPEVPEWKKHVIGGKKSSF----------------------------------GKKTDLTL 579
            ...:..::...:|.::..:|.:|                                  .||||...
Mouse   126 KINSEKKLDNQEKKLLNQEKKTFRITDKSYIDRDSEYLLQENEPNLSLDQHLLEDLQRKKTDPRY 190

  Fly   580 VEQ---RQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTARGK-----IGC 636
            :|.   |:.||.|.::.:|:..:.::|:.::.||||.|||||:||::.: .:..|||     |.|
Mouse   191 IEMQRFRKKLPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILD-NYIERGKGSACRIVC 254

  Fly   637 TQPRRVAAMSVAKRVAEE--YGCRLGQEVGYTIRFED-CTSPETIIKYMTDGMLLRECLMEAELK 698
            |||||::|:|||:|||.|  ..|..|...||.||.:. ....:..|.|.|.|::|:....::.|.
Mouse   255 TQPRRISAISVAERVATERAESCGNGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDSRLS 319

  Fly   699 SYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTF 763
            |.|.|:|||.|||.:.:|||..::|..:..|.:||:|:.||||:|.|||:||...|:..|||.||
Mouse   320 SVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTF 384

  Fly   764 P-VEVL------------------------------------------------YTKEPETDYLD 779
            | ||.|                                                |.||..|.| .
Mouse   385 PVVEYLLEDIIEKIRYVPDQKEHRSQFKRGFMQGHVNRQEKEEKEAIYKERWPAYIKELRTRY-S 448

  Fly   780 ASLITVMQ------------------IHLREPPGDILLFLTGQEEIDTACEILYERM--KSLGPD 824
            ||.:.|:|                  |.|.|..|.||:||.|.:.|.|..::|..::  ||    
Mouse   449 ASTVDVLQMMDDDKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKS---- 509

  Fly   825 VPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSK 889
             .:.:|:|::|.:|:..||::|...|.|.||:||||||||||:|||.:.||:|.|.:|:..::::
Mouse   510 -DKFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQ 573

  Fly   890 TGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPT-PVPEIQRTNLATTVLQL 953
            ..:.::....:|:|.||||.|||||..||..|.||  ...|..:|.. .:|||.||.|....||:
Mouse   574 NNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLY--NGLRASLLDDYQLPEILRTPLEELCLQI 636

  Fly   954 KTMGINDLLHF--DFMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRRMAEFPLEPNLSKMLIM 1016
            |.:.:..:.:|  ..||.|..|::|::::.|..|||||.:..||.||..:|..|:||::.||::.
Mouse   637 KILRLGGIAYFLSRLMDPPSNEAVVLSIKHLMELSALDKQEELTPLGVHLARLPVEPHIGKMILF 701

  Fly  1017 SVALQCSDEILTIVSMLSVQNVFYRPKDKQALAD-QKKAKFNQAEGDHLTLLAVYNSWKNNK--- 1077
            .....|.|.:|||.:.||.::.|..|..|:.:|| ::|....:...||||::..:..|:..|   
Mouse   702 GALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKELAKETRSDHLTVVNAFEGWEEAKRRG 766

  Fly  1078 --FSNAWCYENFVQIRTLKRSQDVRKQ----LLG---IMDRHKLD-VVSAGKNSVRIQKA-ICSG 1131
              :...:|:|.|:...||:...:::.|    |||   :..|...| ..:...::.:|.|| ||:|
Mouse   767 FRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRSPKDPKANINSDNEKIIKAVICAG 831

  Fly  1132 FF-------RNAAKKDPQEGYRTLVDSQVVYIHPSSALFNRQP---EWVIYHELVQTTKEYMREV 1186
            .:       .|..||.......|..|. :|.|||.|....:..   .|:|||..::|:..|:.:.
Mouse   832 LYPKVAKIRLNLGKKRKMVKVHTKSDG-LVSIHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYDC 895

  Fly  1187 TTIDPKWLVEF----------------APSFFRFSDPTKLSKFKKNQRLE---PLYNKYEEPNA- 1231
            |.:.|..|:.|                ...:..|..|.:::...|..|.|   .|..|.|.|:. 
Mouse   896 TEVSPYCLLFFGGDISIQKDKDQEIIAVDEWIVFQSPERIAHLVKGLRKELDSLLQEKIESPHPV 960

  Fly  1232 -WRISRVR 1238
             |..::.|
Mouse   961 DWDDTKSR 968

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
peaNP_610928.1 S1_DHX8_helicase 285..363 CDD:240189
HrpA 573..1221 CDD:224557 251/774 (32%)
Dhx36NP_082412.2 Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250|UniProtKB:Q9H2U1 1..193 20/131 (15%)
Required for the pre-miR-134 transport. /evidence=ECO:0000250|UniProtKB:D4A2Z8 1..97 8/33 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250|UniProtKB:Q9H2U1 1..44
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H2U1 46..98 8/34 (24%)
DSM (DHX36-specific motif). /evidence=ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q9H2U1 46..68 1/1 (100%)
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 99..379 87/282 (31%)
HrpA 188..894 CDD:224557 238/715 (33%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 258..310 20/51 (39%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 327..330 2/2 (100%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 380..621 78/248 (31%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 491..550 24/63 (38%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9H2U1 510..521 3/10 (30%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 622..691 26/68 (38%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 631..690 20/58 (34%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 834..898 17/64 (27%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 842..853 3/10 (30%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 863..893 9/29 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53574
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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