DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and Dqx1

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	XP_038964267.1	Gene:	Dqx1 / 680434	RGDID:	1591766	Length:	780	Species:	Rattus norvegicus

Alignment Length:	742	Identity:	228/742 - (30%)
Similarity:	359/742 - (48%)	Gaps:	103/742 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   579 LVEQRQSLPIYKLRDDLIKAVTDNQ--ILIVIGETGSGKTTQITQYLGEC----GFTARGKIGCT 637
            |:|||::|||:..|...::.:..:.  :::|.||.||||:|||.|:..|.    ||.. |::..|
  Rat    35 LLEQRRALPIWAARFLFLEHLESSPTGVVLVSGEPGSGKSTQIPQWCAEFALARGFQT-GQVTVT 98

  Fly   638 QPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSV 702
            ||..:||||:|.|||:|....||.|:||:|..||||.|.|::::..|.:.|:|........::||
  Rat    99 QPYPLAAMSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSV 163

  Fly   703 IMLDEAHERTIHTDVLFGLLK-TAVQKRP--ELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTFP 764
            ::||||.||::.:|:|.|||: |.::..|  ...:|||.:.|:. ||..::..:|...:|..  |
  Rat   164 LVLDEAQERSVASDLLQGLLRDTRLRNLPGDPRVVIVTDSALEP-KFQAFWGNSPTVHVPRE--P 225

  Fly   765 VE---VLYTKEPETDYLDASLITVMQIHLR-EPPGDILLFLTGQEEIDTACEILYERMKSLGPDV 825
            .|   :.|......|.::|:...|:::..| |.|||:|::|..:|||...||.|...|..|....
  Rat   226 GENPTLTYKDTVPADLVEAACQAVLELCQREEAPGDVLVYLPSEEEISLCCESLSREMGMLAVPG 290

  Fly   826 PELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKT 890
            |...:||::......:|| :::......||:|:...:|:.|.::..|.:|:|.|...:.|||.:.
  Rat   291 PLPRVLPLHPGCGQAIQT-VYEDTDVSVRKIVVTHWLADFSFSLPFIQHVIDSGLELRSVYNPRI 354

  Fly   891 GMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKT 955
            ..:|.|:..||:..|:.|..||....||...|||::.....|..|.|.|::...||::.||.||.
  Rat   355 RAESQVLRRISKCQAEARLLRARGFPPGTCLRLYSKSTLDLEAPPLPHPKVCEENLSSLVLLLKR 419

  Fly   956 MGINDLLHFDFMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRRMAEFPLEPNLSKMLIMSVAL 1020
            ..|.:.....|:|.|..|:|:.|||.|..|:||||:|.|:.||..::||||.|.|:|.|:.|...
  Rat   420 KQIAEPGECHFLDRPAPEALMQALEDLDYLAALDDDGDLSDLGIILSEFPLPPELAKALLASCEF 484

  Fly  1021 QCSDEILTIVSMLSVQNVFYRP---KDKQALADQKKAKFNQAEGDHLTLLAVYNSWKNNKFSNAW 1082
            .|.||:||:.:||:....|.||   ..:.||    :.....|:|||.:|:.||.::..:.....|
  Rat   485 NCVDEMLTLAAMLTAAPGFTRPPLCAGEAAL----RRGLEHADGDHSSLIQVYEAFVQSGADETW 545

  Fly  1083 CYENFVQIRTLKRSQDVRKQLLGIMDRHKLDV----VSAGKNSVRIQKAICSGFF------RNAA 1137
            |....:....|.:::.:|.:||.:|.|.:|.:    ..:.:|...:|||:.||:|      |...
  Rat   546 CQARGLSWEALCQARKLRAELLELMQRIELPLSLPAFGSEQNRRDLQKALLSGYFLKAMMRRGLM 610

  Fly  1138 KKDPQE----------------------------------------------------------G 1144
            .|.|.:                                                          .
  Rat   611 SKLPSDSLSTSGWPQTAPLAPYSATQAGITATPALAFFIFCASLLSPPMYLCFNEVARDTDGTGN 675

  Fly  1145 YRTLVDSQVVYIHPSSALFNRQ-----PEWVIYHELVQTTKEYMREVTTIDPKWLVEFAPSFFRF 1204
            |..|....|..:.|.....||:     |.||:||....:....:..|:.|.|:.|||.||.:|..
  Rat   676 YLLLTHKHVAQLSPYCVYRNRRTPAQPPTWVLYHRFSISKDNCLCTVSEIQPEMLVELAPPYFLS 740

  Fly  1205 SDPTKLSKFKKNQRLEPLYNKYEEPNA 1231
            :.|...|:...||..|.     .||:|
  Rat   741 NLPPSESRDLLNQLREG-----TEPSA 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	224/730 (31%)
Dqx1	XP_038964267.1	HrpA	15..>601	CDD:224557	196/574 (34%)
Dqx1	XP_038964267.1	OB_NTP_bind	662..737	CDD:400182	19/74 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820