Protein Alignment pea and YTHDC2

DIOPT Version :10

• Sequence 1: NP_610928.1
• Gene: pea / 36561
• FlyBaseID: FBgn0086895
• Length: 1242
• Species: Drosophila melanogaster
• Sequence 2: XP_011541883.1
• Gene: YTHDC2 / 64848
• HGNCID: 24721
• Length: 1439
• Species: Homo sapiens
• Alignment Length: 1098
• Identity: 274/1098 - (24%)
• Similarity: 443/1098 - (40%)
• Gaps: 367/1098 - (33%)

  Fly   453 DDEADIEIEIVEEE-----------PPFLSGHGRA-LHDLSP---------------VRIVKNPD 490
            |:|..|.:.|..|.           |..|:...|| :|.||.               ...||..|
Human    42 DEEVKIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKKD 106

  Fly   491 GSLAQAAMMQSALSKERRE--QKMLQREQEIEAMPTSLNKNWIDPLP----------EDESRSLA 543
            ||....|||...|:...:.  :.::||      .|.: ||...:.||          |.|:|.::
Human   107 GSETAHAMMTCNLTHNTKHAVRSLIQR------FPVT-NKERTELLPKTERGNVFAVEAENREMS 164

  Fly   544 ANMRGMAAAPPEVPEWKKHVIGGKKSSFGKKTDLTLVEQRQSLPIYKLRDDLIKAVTDNQILIVI 608
            .....:....|::|.              |:.:......|||||:::.:::::|.:.:|::::::
Human   165 KTSGRLNNGIPQIPV--------------KRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIV 215

  Fly   609 GETGSGKTTQITQY-LGEC---GFTARGKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRF 669
            |||||||||||.|: |.:|   |...|  |.||||||:||::||:|||.|...|:||.:||.||.
Human   216 GETGSGKTTQIPQFLLDDCFKNGIPCR--IFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRL 278

  Fly   670 EDCTSPETIIKYMTDGMLLRECLM-EAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELK 733
            |...||:|::.:.|:|:|||..:. ::.|.:.:.:::||.|||...:|.|...|:..:||.|.||
Human   279 ESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLK 343

  Fly   734 LIVTSATLDAVKFSQYFFKAPIFTIPGRTFPVEVL------------------YTKE-------- 772
            ||::||.||...|.:||...|:..|.||.|.|:.:                  |.||
Human   344 LILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEEKQQ 408

  Fly   773 ---------------PET-------------DYLD------ASLITVMQIHLREP---------P 794
                           ||:             |.||      .|.:|...::..||         .
Human   409 TTLTEWYSAQENSFKPESQRQRTVLNVTDEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACL 473

  Fly   795 GDILLFLTGQEEIDTACEILY---------------------------------ERMKSLGPDVP 826
            .||.|    .::||...::.:                                 |::.|:|.:|.
Human   474 SDIWL----HKDIDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVH 534

  Fly   827 E---------------------------------------------------------------- 827
            .
Human   535 SKASNGWMALDWAKHFGQTEIVDLLESYSATLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSF 599

  Fly   828 --------------------------LIILPVYS--------------------------ALPSE 840
                                      ||.||.|.                          .|.|.
Human   600 DDEKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFADSTHRYQVFMLHSN 664

  Fly   841 MQT----RIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPIS 901
            |||    ::....|||.||::::|||||||:|::.:.:|:|.|.||:|.:::...:..|.:..||
Human   665 MQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWIS 729

  Fly   902 QAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMG-----INDL 961
            :|:|.||.|||||..||..:||::...::: ||....||:.|..|....|..|.:.     |.|.
Human   730 KASAIQRKGRAGRCRPGICFRLFSRLRFQN-MLEFQTPELLRMPLQELCLHTKLLAPVNCPIADF 793

  Fly   962 LHFDFMDAP-PVESLVM--ALEQLHSLSALDDEGLLTRLGRRMAEFPLEPNLSKMLIMSVALQCS 1023
            |    |.|| |..:|::  |::.|.::.|:|....||.||..:|:.|:||:|.||::.:|.|:|.
Human   794 L----MKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCL 854

  Fly  1024 DEILTIVSMLSVQNVFYRPKDKQALADQKKA------KFNQ-AEGDHLTLLAVYNSW---KNNKF 1078
            |.||||...|:.::.|..|..    |.||:|      :|.. |..||:.||..:.:|   :::.:
Human   855 DPILTIACTLAYRDPFVLPTQ----ASQKRAAMLCRKRFTAGAFSDHMALLRAFQAWQKARSDGW 915

  Fly  1079 SNAWCYENFVQIRTLKRSQDVRKQLLG-------IMDRHKLDVVSAGKNSVR---IQKAICSGFF 1133
            ..|:|.:||:...|::....:|.||||       :..|...|:.....||..   ::.|:.:|.:
Human   916 ERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMY 980

  Fly  1134 RNAAKKDPQEGYRTLVDSQVVYIHPSSALFNRQ------------------PEWVIYHELVQTTK 1180
            .|....|.:....|....:.|..||:|.|...|                  .:|:||.|:.:..:
Human   981 PNLVHVDRENLVLTGPKEKKVRFHPASVLSQPQYKKIPPANGQAAAIKALPTDWLIYDEMTRAHR 1045

  Fly  1181 -EYMREVTTIDPKWLVEFAPSFFRFSDPTKLSKFKKNQRLEPLYNKYEEPNAWRISRV 1237
             ..:|..:.:.|..::.|.       .|.:|:.           |..:||:::|:..:
Human  1046 IANIRCCSAVTPVTILVFC-------GPARLAS-----------NALQEPSSFRVDGI 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	GH2-like_DHX8	7..74	CDD:409668
		S1_DHX8_helicase	285..363	CDD:240189
		HrpA	578..>1203	CDD:441249	234/898 (26%)
YTHDC2	XP_011541883.1	R3H_DEXH_helicase	46..104	CDD:100077	11/57 (19%)
		HrpA	188..>948	CDD:441249	212/774 (27%)
		DEXHc_YTHDC2	193..368	CDD:350745	75/176 (43%)
		ANK repeat	505..537	CDD:293786	4/31 (13%)
		ANK repeat	539..564	CDD:293786	0/24 (0%)
		OB_NTP_bind	971..1066	CDD:400182	18/101 (18%)
		YTH	1289..1404	CDD:410979