DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pea and DHX35

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_068750.2	Gene:	DHX35 / 60625	HGNCID:	15861	Length:	703	Species:	Homo sapiens

Alignment Length:	705	Identity:	321/705 - (45%)
Similarity:	462/705 - (65%)	Gaps:	37/705 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   549 MAAAPPEVPEWKKHV------IGGKKSSFGKKTDLTLV----------EQRQSLPIYKLRDDLIK 597
            |||....|..|:...      |..::.|..:.:..|:|          :|||.||::|||:.::.
Human     1 MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILY 65

  Fly   598 AVTDNQILIVIGETGSGKTTQITQYLGECGFTARGK-IGCTQPRRVAAMSVAKRVAEEYGCRLGQ 661
            .:.:.|.::::||||.||:|||.|||.|.|:||.|: :|.||||||||::||.|||||.|..||.
Human    66 LIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGH 130

  Fly   662 EVGYTIRFEDCTSP-ETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTA 725
            ||||.|||:|||.. .|.||::|||||:||.:::..|..|||||||||||||::||:..||||..
Human   131 EVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKI 195

  Fly   726 VQKRPELKLIVTSATLDAVKFSQYFFK----------APIFTIPGRTFPVEVLYTKEPETDYLDA 780
            .:||.:|:|||.||||||.||..:|.:          ..|.|:.||||||::.|.:.|..||:.:
Human   196 QKKRGDLRLIVASATLDADKFRDFFNQNETSDPARDTCVILTVEGRTFPVDIFYLQSPVPDYIKS 260

  Fly   781 SLITVMQIHLREPPGDILLFLTGQEEIDTACEILYERMKSLGPD--VPELIILPVYSALPSEMQT 843
            ::.||::||..|..||:|.|||||||::|...:|.|:.::|...  ...|.:||:|:.|||..|.
Human   261 TVETVVKIHQTEGDGDVLAFLTGQEEVETVVSMLIEQARALARTGMKRHLRVLPMYAGLPSFEQM 325

  Fly   844 RIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQR 908
            ::|:......|||::|||:||||:||.||.||:|.||||.:.||.:|.::.|||.|:|||:|.||
Human   326 KVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQR 390

  Fly   909 AGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPVE 973
            |||.||:..||.||||||.|: |::..:.|||:||:|||..:||||.:||:::|.|.||..||.:
Human   391 AGRGGRSRSGKCYRLYTEEAF-DKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQ 454

  Fly   974 SLVMALEQLHSLSALDDEGLLTR-LGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQN 1037
            |:|.|||.|::|..||.:..||. ||.|:|||||.|..:|||:.|....||.|||:|.:|:.:||
Human   455 SMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQN 519

  Fly  1038 VFYRPKDKQALADQKKAKFNQAEGDHLTLLAVYNSW-KNNKFSNAWCYENFVQIRTLKRSQDVRK 1101
            :|..|.::::.|.:...||...||||||:|.:|.:: |:||.|. ||.|:|:..:.|.|:..||:
Human   520 IFVVPPNQKSHAIRVHRKFAVEEGDHLTMLNIYEAFIKHNKDSK-WCQEHFLNYKGLVRAATVRE 583

  Fly  1102 QLLGIMDRHKLDVVSAGKNSVRIQKAICSGFFRNAAKKDPQEGYRTLVDSQVVYIHPSSALF-NR 1165
            ||..::.:.::...|:..:...:.:.|.||||.|||:......|||:.|...::|||:|.|: .:
Human   584 QLKKLLVKFQVPRKSSEGDPDLVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAEK 648

  Fly  1166 QPEWVIYHELVQTTKEYMREVTTIDPKWLVEFAPSFFRFSDPTKLSKFKKNQRLE 1220
            .|.||||:|::||:|.|||:||.|:..||:|.||.|::  ..|.||...|..:::
Human   649 PPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQ--QGTHLSLKAKRAKVQ 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	314/675 (47%)
DHX35	NP_068750.2	DEXDc	53..224	CDD:214692	97/170 (57%)
		DEXDc	73..211	CDD:238005	84/137 (61%)
		DEAH box	176..179		2/2 (100%)
		HELICc	301..396	CDD:197757	47/94 (50%)
		HA2	465..549	CDD:214852	38/83 (46%)
		OB_NTP_bind	584..683	CDD:285018	39/98 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730