DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pea and dhx40

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	XP_021322026.1	Gene:	dhx40 / 570225	ZFINID:	ZDB-GENE-080507-1	Length:	734	Species:	Danio rerio

Alignment Length:	701	Identity:	294/701 - (41%)
Similarity:	439/701 - (62%)	Gaps:	40/701 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   573 KKTDLTLVEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTARGKIGCT 637
            |::..|...:.:.||||:.:|.|::||.:|..|||.||||||||||:.|||.:.|.:..|:||.|
Zfish     5 KRSSETEHHESKKLPIYQYKDKLVQAVEENTFLIVTGETGSGKTTQLPQYLYKAGLSRNGRIGVT 69

  Fly   638 QPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSV 702
            |||||||::||:||:.|...|||:||||.:||:||::.:|:|||||||.||||.|.:..|..||:
Zfish    70 QPRRVAAITVAQRVSSEMQVRLGEEVGYQVRFDDCSTKDTMIKYMTDGCLLREILADPSLTQYSI 134

  Fly   703 IMLDEAHERTIHTDVLFGLLKTAVQK-----RPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRT 762
            ::|||||||:::||||.||||..:.|     :..||::|.||||:..|.|.::...|:|||||||
Zfish   135 VILDEAHERSLNTDVLLGLLKKTLLKGSRGNKTPLKVVVMSATLETEKLSSFYGNCPVFTIPGRT 199

  Fly   763 FPVE-----VLYTKEPETD-YLDASLITVMQIHLREPPGDILLFLTGQEEIDTACEILYERMKSL 821
            :||:     ::..|:.|:. |:...:...:.:|..|..||||:|||||.||:.||::|:|:.:.|
Zfish   200 YPVKETFCNLIGPKDKESSVYVKEVVKMTLDVHTNEAAGDILVFLTGQSEIEKACDLLFEKAEIL 264

  Fly   822 -------GPDVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPG 879
                   ...|..|:||.:|.::|::.|.:||.|||.|.||.|:|||||.||||||||.|:||.|
Zfish   265 DYRYDVHDRSVDGLLILSLYGSMPTDQQRQIFQPAPKGVRKCVVATNIAATSLTIDGIRYIVDSG 329

  Fly   880 FVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPT-PVPEIQR 943
            ||||..:||:.|:|.|.|.|||::.|:|||||||||..||.:|:|: :.:.|..:|. .:|||||
Zfish   330 FVKQLNHNSRVGLDILEVVPISKSEAQQRAGRAGRTAAGKCFRIYS-KDFWDTCMPEYTIPEIQR 393

  Fly   944 TNLATTVLQLKTMGINDLLHFDFMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRRMAEFPLEP 1008
            |:|.:.:|.||.:|::|::.|.::|.|....::.||:||:...|:|..|.:|:|||.|.||||.|
Zfish   394 TSLTSVILTLKCLGVHDVIRFPYLDCPEERFILTALKQLYQYDAIDRRGEVTKLGRLMVEFPLPP 458

  Fly  1009 NLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRP----KDKQALADQKK-AKFNQAEGDHLTLLA 1068
            ||::.|:.:.||.|.|.:|.:.:||||:|:|.||    |.|:|....|: |..:....|.|.||.
Zfish   459 NLTRALLKAAALGCEDIMLPVAAMLSVENIFIRPGKPEKQKEAEVRHKEIAACSGGSNDFLMLLC 523

  Fly  1069 VYNSWKNNKFSNAWCYENFVQIRTLKRSQDVRKQLLGIMDRHKLD-----VVSAGKNSVRIQKAI 1128
            |:...:.::..:|||.||::..|.:|.:..|..||..|:.|.|..     ....|..|..:::.:
Zfish   524 VFEKCRASENPSAWCKENWIHWRAVKSAFSVETQLREILLRLKQQKDFPHERFEGSRSELLRQCL 588

  Fly  1129 CSGFFRNAAKKDPQEGYRTL-VDSQVVYIHPSSALFNR--QPEWVIYHELVQTTKEYMREVTTID 1190
            |.|:|.|.|::...:.:.|: .....|.|||||.||.:  |.:|:|:|:::.|::.|:|.|..|.
Zfish   589 CLGYFTNVARRSIGKSFCTMDGHGSSVLIHPSSCLFGQELQLDWIIFHDVLVTSRVYVRTVCPIR 653

  Fly  1191 PKWLVEFAPSFFRFSDPTKLSKFKKNQRLEPLYNKYEEPNAWRISRVRRRR 1241
            ..|:.:..|..... |..:||...:.:..:      ||...|......:|:
Zfish   654 YDWVKDLLPKLHEI-DVYELSSVAREEVTD------EEMVQWEKKEAAKRQ 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	290/679 (43%)
dhx40	XP_021322026.1	HrpA	15..696	CDD:224557	291/688 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820