Protein Alignment pea and DHX33

DIOPT Version :10

• Sequence 1: NP_610928.1
• Gene: pea / 36561
• FlyBaseID: FBgn0086895
• Length: 1242
• Species: Drosophila melanogaster
• Sequence 2: NP_064547.2
• Gene: DHX33 / 56919
• HGNCID: 16718
• Length: 707
• Species: Homo sapiens
• Alignment Length: 703
• Identity: 312/703 - (44%)
• Similarity: 434/703 - (61%)
• Gaps: 37/703 - (5%)

  Fly   534 LPEDESRSLAANMRGMAAAPP----EVPEWKKHVI------GGKKSSFGKKTDLTLVE------- 581
            :||:.....|...| ..:.||    ..|..::.|:      ||:....|::....|.:
Human     1 MPEEAGFPPAKRFR-PGSGPPSRAGSFPPGRQVVMLLTAGSGGRGGGGGRRQQPPLAQPSASPYP 64

  Fly   582 -----QRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTARGKIGCTQPRR 641
                 ||:||||::.|..|:..:.:....::||||||||||||.|||.|.|.:.:|.|..|||||
Human    65 EAVELQRRSLPIFQARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLYEGGISRQGIIAVTQPRR 129

  Fly   642 VAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLD 706
            |||:|:|.||::|....||:.||||:||:|.||.:|.||::||||||||.:.::.|:.||.::||
Human   130 VAAISLATRVSDEKRTELGKLVGYTVRFDDVTSEDTRIKFLTDGMLLREAISDSLLRKYSCVILD 194

  Fly   707 EAHERTIHTDVLFGLLKTAVQKRPE-----LKLIVTSATLDAVKFSQYFFKAPIFTIPGRTFPVE 766
            ||||||||||||||::|.|.::|.|     ||:||.|||:|...|||||..||:..:.||..|::
Human   195 EAHERTIHTDVLFGVVKAAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNGAPVLYLEGRQHPIQ 259

  Fly   767 VLYTKEPETDYLDASLITVMQIHLREPPG-DILLFLTGQEEIDTACEILYERMKSLGPDVPELII 830
            |.|||:|:.|||.|:|::|.|||...|.. |||:||||||||:...:...:..|.|....|.:::
Human   260 VFYTKQPQNDYLHAALVSVFQIHQEAPSSQDILVFLTGQEEIEAMSKTCRDIAKHLPDGCPAMLV 324

  Fly   831 LPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSL 895
            ||:|::||...|.|:|..||.|.|||:|:|||||||:||.||.||||.|.||.|.||..:|::.|
Human   325 LPLYASLPYAQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVL 389

  Fly   896 VVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYR--DEMLPTPVPEIQRTNLATTVLQLKTMGI 958
            .|..:|:..|.||.|||||...|..||||||..:.  |:|   .||||||.|||:.:|||..|.:
Human   390 AVQRVSKTQAWQRTGRAGREDSGICYRLYTEDEFEKFDKM---TVPEIQRCNLASVMLQLLAMKV 451

  Fly   959 NDLLHFDFMDAPPVESLVMALEQLHSLSAL---DDEGLLTRLGRRMAEFPLEPNLSKMLIMSVAL 1020
            .::|.||||..|..:.:..|:.||..|.||   ||:..||.:||:||.|||||..:|.::||...
Human   452 PNVLTFDFMSKPSPDHIQAAIAQLDLLGALEHKDDQLTLTPMGRKMAAFPLEPKFAKTILMSPKF 516

  Fly  1021 QCSDEILTIVSMLSVQNVFYRPKDKQALADQKKAKFNQAEGDHLTLLAVYNSWKNNKFSNAWCYE 1085
            .|::|||||||:|||.:|.:.|..::......:.||..:||||:|||.:|.::||...:..||.|
Human   517 HCTEEILTIVSLLSVDSVLHNPPSRREEVQGVRKKFISSEGDHMTLLNIYRTFKNLGGNKDWCKE 581

  Fly  1086 NFVQIRTLKRSQDVRKQLLGIMDRHKLDVVSAGKNSVRIQKAICSGFFRNAAKKDPQEGYRTLVD 1150
            |||..:.:....:||.||..|..:..:.:.|:..:...:::.:....|.:.|:..|...|.|...
Human   582 NFVNSKNMTLVAEVRAQLRDICLKMSMPIASSRGDVESVRRCLAHSLFMSTAELQPDGTYATTDT 646

  Fly  1151 SQVVYIHPSSALFNRQPEWVIYHELVQTTKEYMREVTTIDPKWLVEFAPSFFR 1203
            .|.|.|||||.||:.:|..|:|.||:.|.|.|||::..||.:||.|.||.:||
Human   647 HQPVAIHPSSVLFHCKPACVVYTELLYTNKCYMRDLCVIDAQWLYEAAPEYFR 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	GH2-like_DHX8	7..74	CDD:409668
		S1_DHX8_helicase	285..363	CDD:240189
		HrpA	578..>1203	CDD:441249	299/647 (46%)
DHX33	NP_064547.2	Required for nucleolar location. /evidence=ECO:0000269|PubMed:26100019	1..80		18/79 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..64		12/63 (19%)
		HrpA	73..>700	CDD:441249	298/630 (47%)
		DEAH box	194..197		2/2 (100%)
		HA2, required for interaction with EIF3G and RPL26. /evidence=ECO:0000269|PubMed:26100019	471..562		41/90 (46%)
		Critical for rDNA-binding. /evidence=ECO:0000250	547..558		3/10 (30%)