DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pea and dhx32b

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	XP_687318.4	Gene:	dhx32b / 558937	ZFINID:	ZDB-GENE-130613-5	Length:	729	Species:	Danio rerio

Alignment Length:	660	Identity:	229/660 - (34%)
Similarity:	367/660 - (55%)	Gaps:	40/660 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   579 LVEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTAR---GKIGCTQPR 640
            |:.:|:.||:::.:.:.:.::.::||:||.|...:|::|||.|:..|...:|:   |.:.|||..
Zfish    44 LLRERKCLPVWEAKCEFMDSLINSQIVIVTGTAKTGQSTQIPQWCAEFCLSAQYQNGMVVCTQIH 108

  Fly   641 RVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIML 705
            ....:.:|.|||:|....:|.||||:|..:.|.|.:|:::|.||.:||||.:.:..|:...|::|
Zfish   109 HQTTVELALRVADEMDVNIGNEVGYSIPLQACCSQDTVLRYCTDDVLLREMMSDPLLEQCGVVVL 173

  Fly   706 DEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTFPVEVLY- 769
            |:|.|||:.||:|.||||..:..||||:|::.||...:.|..:::...|...:.|.. |.|||:
Zfish   174 DQAQERTVSTDLLLGLLKDVLLTRPELRLVILSAPHSSEKLLRHYGSVPQIKLEGPQ-PCEVLFG 237

  Fly   770 -TKEPETDYLDASLITVMQIHLREPPGDILLFLTGQEEIDTACEILYERMKSLGPDVPELIILPV 833
             .:....|||.::|...::||..|..|||:.||..::||:.|..||.....:|.....||:  ||
Zfish   238 SGRGGVKDYLCSALRLALEIHQNENHGDIVAFLATEQEIECAHAILRREGANLALSHGELV--PV 300

  Fly   834 YSALPSEMQTRIFDPAPAGSRKVVIATNIAETSL-TIDGIFYVVDPGFVKQKVYNSKTGMDSLVV 897
             |..|.:..: :.....:.||:|.:..:.:|... .:..|.:|:|.|..|:.|||.:...:|:|:
Zfish   301 -SLCPRQGDS-LSLTEESKSRRVFLTCSPSEDLFWALHTIRFVIDAGVQKRYVYNPRIRANSIVI 363

  Fly   898 TPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPT-PVPEIQRTNLATTVLQLKTMGINDL 961
            .|||::.|:.|...||.|  ||.:.||.|    |..||. .||.:..:::.:|||.||.|.|..|
Zfish   364 RPISKSQAESRKQLAGPT--GKCFCLYQE----DTSLPAESVPHLLESDITSTVLFLKRMEIAGL 422

  Fly   962 LHFDFMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRRMAEFPLEPNLSKMLIMSVALQCSDEI 1026
            .|.|.:|.|..|.|:.|||:|..|:||||:|.|:.:|..|:||||||.::|.|:.|....|..|:
Zfish   423 SHCDLIDRPDPEGLMQALEELDYLAALDDDGNLSEIGIIMSEFPLEPQMAKTLLASCEFDCVCEV 487

  Fly  1027 LTIVSMLSVQNVFYRP----KDKQALADQKKAKFNQAEGDHLTLLAVYNSW---KNNKFSNA--W 1082
            |||.:||:..:.|..|    :.|..|..|   ||..|||||.||:.::|::   |:..:|..  |
Zfish   488 LTIAAMLTAPSCFIIPPVEMRQKALLCHQ---KFQHAEGDHFTLINIFNAYRYAKDGSYSKVEQW 549

  Fly  1083 CYENFVQIRTLKRSQDVRKQLLGIMDRHKLDV----VSAGKNSVRIQKAICSGFFRNAAKK-DPQ 1142
            |.|:|:.:..|:.:..:|.:|..|:.|.:|.|    ..:..||:.:::|:.:|||...|:. |..
Zfish   550 CDEHFLSLAALQTADAIRSELTEILKRLELPVSLPAFGSRSNSLNVRRALLAGFFMQVARDIDGS 614

  Fly  1143 EGYRTLVDSQVVYIHPSSAL---FNRQ--PEWVIYHELVQTTKEYMREVTTIDPKWLVEFAPSFF 1202
            ..|..|....|..|||.|..   .|::  ||||:|||...:....:|.|:.|.....::.||.:|
Zfish   615 GNYFMLTHKHVAQIHPLSGYGLEVNKKNLPEWVLYHEHTLSENNCIRTVSQISAIEFIQMAPQYF 679

  Fly  1203 RFSDPTKLSK 1212
            .::.|:..||
Zfish   680 FYNLPSSESK 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	229/660 (35%)
dhx32b	XP_687318.4	HrpA	30..661	CDD:224557	220/630 (35%)
		DEXDc	68..207	CDD:238005	57/138 (41%)
		HA2	445..529	CDD:214852	38/86 (44%)
		OB_NTP_bind	568..678	CDD:285018	33/109 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920