DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and DHX29

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_061903.2	Gene:	DHX29 / 54505	HGNCID:	15815	Length:	1369	Species:	Homo sapiens

Alignment Length:	1365	Identity:	312/1365 - (22%)
Similarity:	529/1365 - (38%)	Gaps:	387/1365 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 INLMRPSRPGGASQEKTVGDKKEDKKSQLLKMFPGLALPNDTYSKKEESDDDEKVKAKPEKHSET 135
            :||...:.|.|.|||......|...|.|..::...::.|....:|..|.|...|.| |.||:.|.
Human   164 LNLSDDALPEGFSQEFEEQQPKSRPKFQSPQIQATISPPLQPKTKTYEEDPKSKPK-KEEKNMEV 227

  Fly   136 HKK------------TDMSDVDAAMMELEALAPGE-----GATLVRPHKEVSS--RDRHKRRSRD 181
            :.|            .:.::...::.|.|...|.|     .|.|:...::.::  .:::|:..::
Human   228 NMKEWILRYAEQQNEEEKNENSKSLEEEEKFDPNERYLHLAAKLLDAKEQAATFKLEKNKQGQKE 292

  Fly   182 RDTKRRSRSRE----DRH---SDRRRSRSRDKERRRRSRSRDNR--------RRSRSREDRDRDR 231
            ...|.|...||    :.|   :...:...:..||::...:.:..        .:|.:..:.::|:
Human   293 AQEKIRKFQREMETLEDHPVFNPAMKISHQQNERKKPPVATEGESALNFNLFEKSAAATEEEKDK 357

  Fly   232 DRRHKSSSSRDHHERRR-----RSRSRSTERRDRRDRSRDCSEKMPPPSAAMTDDPEAGKIYSGK 291
                    .::.|:.|.     ||.:..:.::...|..|....|.|.||...
Human   358 --------KKEPHDVRNFDYTARSWTGKSPKQFLIDWVRKNLPKSPNPSFEK------------- 401

  Fly   292 IANIVPFGCFVQLFGLRKRWEGLVHISQLRAEGRVTDVTEVVTRNQTVKVKVMSIT--------G 348
                ||.|         :.|:..|.:  :::|..|..|...:.....::.:.:..|        |
Human   402 ----VPVG---------RYWKCRVRV--IKSEDDVLVVCPTILTEDGMQAQHLGATLALYRLVKG 451

  Fly   349 QKVSLSMKEVDQDSGKDLNPLSHAPEDDESLRDRNPDGPFSSSTSMLN-LQGNGMEGDEHESRKR 412
            |.|...:....:|...:.:......|:...:....|...|.:  .:|| |:....:..:|...||
Human   452 QSVHQLLPPTYRDVWLEWSDAEKKREELNKMETNKPRDLFIA--KLLNKLKQQQQQQQQHSENKR 514

  Fly   413 VTRISSPERWEIKQMISSGVLDRSEMPDFDEETGLLPKDEDDEADIEIEIVEEEPPFLSGHGRAL 477
            .......|.||  .::|                     |||..|             ||.....:
Human   515 ENSEDPEESWE--NLVS---------------------DEDFSA-------------LSLESANV 543

  Fly   478 HDLSPVRIVKNPDGSLAQAAMMQSALSKERREQKMLQREQEIEAMPTSLNKNWIDPLPEDESRSL 542
            .||.|||                          .:.::.|
Human   544 EDLEPVR--------------------------NLFRKLQ------------------------- 557

  Fly   543 AANMRGMAAAPPEVPEWKKHVIGGKKSSFGKKTDLTLVEQRQSLPIYKLRDDLIKAVTDNQILIV 607
                        ..|:::|                 |:::||.||::|.||.:::.:..:::::|
Human   558 ------------STPKYQK-----------------LLKERQQLPVFKHRDSIVETLKRHRVVVV 593

  Fly   608 IGETGSGKTTQITQYL-----------GECGFTARGKIGCTQPRRVAAMSVAKRVAEEYGCRLG- 660
            .|||||||:||:..:|           .:|      .|.||||||::|:|:|.||.:|.||..|
Human   594 AGETGSGKSTQVPHFLLEDLLLNEWEASKC------NIVCTQPRRISAVSLANRVCDELGCENGP 652

  Fly   661 ----QEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGL 721
                ...||.||.|......|.:.|.|.|:|||:...:..|.:.|.:::||.|||::.:|.|..:
Human   653 GGRNSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLII 717

  Fly   722 LKTAVQKRPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTFPVEVLYTK----------EPETD 776
            ||..:|||.:|.||:.|||:|:.|||.||...||..|.||::||||.:.:          |.:::
Human   718 LKEILQKRSDLHLILMSATVDSEKFSTYFTHCPILRISGRSYPVEVFHLEDIIEETGFVLEKDSE 782

  Fly   777 Y-------------------------------------------------------------LDA 780
            |                                                             ::.
Human   783 YCQKFLEEEEEVTINVTSKAGGIKKYQEYIPVQTGAHADLNPFYQKYSSRTQHAILYMNPHKINL 847

  Fly   781 SLITVMQIHLREPP------GDILLFLTGQEEIDTACEIL-------YERMKSLGPDVPELIILP 832
            .||..:..:|.:.|      |.:|:||.|...|....::|       .||.|          ::.
Human   848 DLILELLAYLDKSPQFRNIEGAVLIFLPGLAHIQQLYDLLSNDRRFYSERYK----------VIA 902

  Fly   833 VYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVV 897
            ::|.|.::.|...|...|.|.||:|:|||||||.:||..:.:|:|.|..|:..|:..:.|.|||.
Human   903 LHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVE 967

  Fly   898 TPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLL 962
            |.:|:|:|.||.|||||...|..:|:||...: :..:...||||.|..|....|.:....:....
Human   968 TFVSKASALQRQGRAGRVRDGFCFRMYTRERF-EGFMDYSVPEILRVPLEELCLHIMKCNLGSPE 1031

  Fly   963 HF--DFMDAPPVESLVMALEQLHSLSALD-DEGLLTRLGRRMAEFPLEPNLSKMLIMSVALQCSD 1024
            .|  ..:|.|.::.:..|:..|..:.|.: :|..||.||:.:|..|:...:.||||......|.|
Human  1032 DFLSKALDPPQLQVISNAMNLLRKIGACELNEPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLD 1096

  Fly  1025 EILTIVSMLSVQNVFYRPKDKQALADQKKAKFNQAEGDHLTLLAVYNSWKNNKFSN------AWC 1083
            .:.|:.::::.::.|..|..::..||..|:....|:.||||:...|..||..:...      .:|
Human  1097 PVATLAAVMTEKSPFTTPIGRKDEADLAKSALAMADSDHLTIYNAYLGWKKARQEGGYRSEITYC 1161

  Fly  1084 YENFVQIRTLKRSQDVRKQLLGIMDRHKLDVVSAGKNS--------------------VRIQKAI 1128
            ..||:...:|...:||:::|:.:       |.:||.:|                    :.:.||:
Human  1162 RRNFLNRTSLLTLEDVKQELIKL-------VKAAGFSSSTTSTSWEGNRASQTLSFQEIALLKAV 1219

  Fly  1129 -CSGFFRNAAK------KDPQEGYRTLVDSQ--VVYIHPSSALFNRQPE---WVIYHELVQTTKE 1181
             .:|.:.|..|      .|..|....:|::.  ...:||||.  ||..:   |::|.|.::..:.
Human  1220 LVAGLYDNVGKIIYTKSVDVTEKLACIVETAQGKAQVHPSSV--NRDLQTHGWLLYQEKIRYARV 1282

  Fly  1182 YMREVTTIDPKWLVEFA--------------PSFFRFSDPTKLSKFKKNQRL---EPLYNKYEEP 1229
            |:||.|.|.|..::.|.              ..:..|..|.|::...|..|:   ..|..|.|.|
Human  1283 YLRETTLITPFPVLLFGGDIEVQHRERLLSIDGWIYFQAPVKIAVIFKQLRVLIDSVLRKKLENP 1347

Fly 1230 1229
Human 1348 1347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189	13/85 (15%)
pea	NP_610928.1	HrpA	573..1221	CDD:224557	221/805 (27%)
DHX29	NP_061903.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..75
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..226		15/50 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..526		6/25 (24%)
		DEXDc	578..764	CDD:214692	76/191 (40%)
		DEXDc	589..736	CDD:238005	58/152 (38%)
		DEAH box. /evidence=ECO:0000255\|HAMAP-Rule:MF_03068	702..705		2/2 (100%)
		Helicase_C	847..985	CDD:278689	51/147 (35%)
		HA2	1056..1137	CDD:214852	23/80 (29%)
		OB_NTP_bind	1179..1302	CDD:285018	29/131 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810