Protein Alignment pea and Dhx57

DIOPT Version :10

• Sequence 1: NP_610928.1
• Gene: pea / 36561
• FlyBaseID: FBgn0086895
• Length: 1242
• Species: Drosophila melanogaster
• Sequence 2: NP_001178836.1
• Gene: Dhx57 / 366532
• RGDID: 1310340
• Length: 1391
• Species: Rattus norvegicus
• Alignment Length: 1353
• Identity: 324/1353 - (23%)
• Similarity: 551/1353 - (40%)
• Gaps: 362/1353 - (26%)

  Fly   183 DTKRRSRSREDRHSDRRRSRSRDKERRRRS-------RSRDNRRRSRS--REDRDRDRDR-RHKS 237
            ::||.||..:   |::.:..:|.|.:.:..       .:.:|:.:.::  |:.:::..|. ..:.
  Rat    73 ESKRPSRPCD---SNKSKGETRPKWKPKAKVPLQTLHMTSENQEKVKALLRDLQEQGADAGSERG 134

  Fly   238 SSSRDHHERRRRSRSRSTERRDRRDRSRDC-------SEKMPPPSAAMTDDPEAGKIYS------ 289
            ||..:..:....:..:|...........||       .|::.||....|..|.|.:..|
  Rat   135 SSGEEEEDAPEGAAEQSWSAGPEPTFLPDCRPWEYIGPEEVEPPLPEFTVSPLAVQKLSRYGFHT 199

  Fly   290 --------------GKIANIVPFGCFVQLFGLRKRW-EGLVHISQLRAEGRVTDVTEVVTRNQTV 339
                          |.....:...||.:.||.|... |..|.:|          :.|.|.:.|..
  Rat   200 EHCQLALRICEGDLGAALEHLLHQCFSETFGERMALSEAAVSVS----------LDECVEQRQEE 254

  Fly   340 KVKVMSITGQKVSLSMKEVDQDSGKDLNPL------SHAPEDDESLRDRNPDGPFSSSTSMLNLQ 398
            .:.:.||.|:|....::......|.:|..|      |...|.::::||.:|:      |....|:
  Rat   255 TLALKSICGEKFIERIQNRVWTIGLELEYLTNKFCKSKQKESNKNVRDTSPE------TCKFYLK 313

  Fly   399 GNGMEG-----------------------DEHESRKRVT--------RISSPERWEIKQMISSGV 432
            ||...|                       |.|...:..|        |.|...::..:..:.:..
  Rat   314 GNCKFGSKCKFKHEVPPHQIIGRTERNVNDPHLDAENDTTFLYELQIRFSKDHKYPYQAPLVAFY 378

  Fly   433 LDRSEMP--------DFDEETGL-LPKDEDDEADIEIEIVEEEPPF--LSGHGRALHDLSPVRIV 486
            .....:|        :|.....| ..|..:......|.::|||...  |..|.:..:.:.|:.:.
  Rat   379 STNENLPLACRLHISEFLYGKALEFAKTSEPVVYSLITLLEEESEIVKLLTHTQHKYSVPPINVP 443

  Fly   487 KNP-DGSLAQAAMMQSAL-SKERREQKMLQRE--QEIEAMPTSLNKNWIDPLPEDESRSLAANMR 547
            ..| :..:::.|..:..: |......:||:.|  .|:|           :...|||..:
  Rat   444 PAPSETRISKPAYRKPVIPSNTFLSNQMLEGEGLSELE-----------EDADEDEGPA------ 491

  Fly   548 GMAAAPPEVPEWKKHVIGGK----------KSSFGKKTDL--------------TLVEQRQSLPI 588
                  |.|.|.:.:|...|          ||.|.:.:.:              .::::||.||.
  Rat   492 ------PIVVENESYVNLKKRSYRRCDRPAKSLFAENSKICRQFQMKQASRQFHAILQERQLLPA 550

  Fly   589 YKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTAR----GKIGCTQPRRVAAMSVAK 649
            ::.|:.::|.::.:|::::.|.||.||||||.|::.:......    ..|.||||||::|:|||:
  Rat   551 WEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGPPERVANIICTQPRRISAISVAE 615

  Fly   650 RVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIH 714
            |||:|...|:|..|||.||.|...|..|.:.|.|.|:|||....:|.|:..:.|::||.||||..
  Rat   616 RVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEE 680

  Fly   715 TDVLFGLLKTAVQKRPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTFPVEVLYTKEPETDYLD 779
            :|.|..:||..|.:|..|::|:.||||||..||:||...|:.|||||.|||:..:.:       |
  Rat   681 SDFLLLVLKDIVMQRATLQVILMSATLDAGLFSKYFSYCPVITIPGRAFPVDQFFLE-------D 738

  Fly   780 ASLIT--VMQ------------------------------------IHLRE-------------- 792
            |..:|  |:|                                    :||::
  Rat   739 ALAVTRYVLQDGSPYMRSMKQIAKERLKARHNRTALEEVEEDLRLALHLQDEEESVKDTIPDQQL 803

  Fly   793 -----------------------------------------------PPGDILLFLTGQEEIDTA 810
                                                           |||.||:||.|..||
  Rat   804 DFKQLLVRYKGVSKSVIKTMSVMDFEKVNLELIEALLEWIVDGKHSYPPGAILVFLPGLAEI--- 865

  Fly   811 CEILYERMKS----LGPDVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDG 871
             ::|||:::|    ........:|.|::|:|.||.|..:|...|.|..|::|:|||||||:|||.
  Rat   866 -KMLYEQLQSNSLFNNRRSHRCVIHPLHSSLSSEEQQAVFVKPPLGVTKIIISTNIAETSITIDD 929

  Fly   872 IFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPT 936
            :.||:|.|.:|:|.|::..||:||..|.:|||.|.||.|||||...|..:.|:|...|..::|..
  Rat   930 VVYVIDSGKMKEKRYDAGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLLKQ 994

  Fly   937 PVPEIQRTNLATTVLQLKTMGINDLLHFD-----FMDAPPVESLVMALEQLHSLSALDDEGLLTR 996
            .:|||||..|....|::|.:.:....:..     .::.|.|:||..:..:|..|.||..:..||.
  Rat   995 QLPEIQRVPLEQLCLRIKILEMFSTHNLQSVFSRLIEPPHVDSLRASKVRLRDLGALTPDEKLTP 1059

  Fly   997 LGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDKQALADQKKAKFNQAEG 1061
            ||..:|..|::..:.|::::....:|.|..|||.:.|:.::.|..|.||:..|:|||.:|..|..
  Rat  1060 LGYHLASLPVDVRIGKLMLLGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFANS 1124

  Fly  1062 DHLTLLAVYNSW-----KNNKFSNAWCYENFVQIRTLKRSQDVRKQLL----------------- 1104
            |:|.||..|..|     ::.:.|..:|.:||:..|||:....:::|..
  Rat  1125 DYLALLCAYKGWQLSTKESARASYNYCRQNFLSGRTLQEMASLKRQFTELLSDIGFVKEGLRAKE 1189

  Fly  1105 ---------GIMDRHKLDVVSAGKNSVRIQKAICSGFFRNAAKKDPQEGYRTLVDSQV------- 1153
                     |::|....:..:..:|...|...:|:..:.|..:....||......|.|
  Rat  1190 IEKRAQGGDGVLDATGEEANTNAENPKLISAVLCAALYPNVVQVKTPEGKFQKTSSGVVRLQPKS 1254

  Fly  1154 ------------VYIHPSSALF---NRQPEWVIYHELVQTTKEYMRE------------------ 1185
                        |:|||||..:   :....:::|||.::|::.::|:
  Rat  1255 AELKFVTKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVS 1319

  Fly  1186 --------VTTIDPKWLVEFAPSFFRFSDPTKLSKFKKNQRLEPLYNKYEEPN 1230
                    |.::|..| :.|..:..:.::..|..:.:.:|.|:   :|.:.|:
  Rat  1320 VQLQRGAFVVSLDDGW-IRFVAASHQVAELVKELRCELDQLLQ---DKIKNPS 1368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	GH2-like_DHX8	7..74	CDD:409668
		S1_DHX8_helicase	285..363	CDD:240189	17/98 (17%)
		HrpA	578..>1203	CDD:441249	233/815 (29%)
Dhx57	NP_001178836.1	UBA_DHX57	184..221	CDD:270502	4/36 (11%)
		RWD_DHX57	245..428	CDD:467661	33/188 (18%)
		zf_CCCH_4	308..326	CDD:465719	4/17 (24%)
		HrpA	548..>1175	CDD:441249	206/637 (32%)
		OB_NTP_bind	1218..1315	CDD:400182	18/96 (19%)