DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pea and Dhx35

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	XP_006235485.1	Gene:	Dhx35 / 362260	RGDID:	1311165	Length:	703	Species:	Rattus norvegicus

Alignment Length:	706	Identity:	326/706 - (46%)
Similarity:	459/706 - (65%)	Gaps:	39/706 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   549 MAAAPPEVPEWKKHVIG----------------GKKSSFGKKTDLTLVEQRQSLPIYKLRDDLIK 597
            |||....|..||....|                |....:.....|::.:|||.||::|||:.::.
  Rat     1 MAAPLGPVKFWKPGTEGPGVSISEERQSVTENSGTTVIYNPYAALSIEQQRQKLPVFKLRNHILY 65

  Fly   598 AVTDNQILIVIGETGSGKTTQITQYLGECGFTARGK-IGCTQPRRVAAMSVAKRVAEEYGCRLGQ 661
            .|.:.|.::::||||.||:||:.|||.|.|:||.|: :|.||||||||::||.|||:|.|..||.
  Rat    66 LVENYQTVVIVGETGCGKSTQVPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVADERGAVLGH 130

  Fly   662 EVGYTIRFEDCTSP-ETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTA 725
            ||||.|||:|||.| .|.||::|||||:||.:::..|..|||:|||||||||::||:..||||..
  Rat   131 EVGYCIRFDDCTDPLATRIKFLTDGMLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKI 195

  Fly   726 VQKRPELKLIVTSATLDAVKFSQYFFK----------APIFTIPGRTFPVEVLYTKEPETDYLDA 780
            .:||.:|:|||.||||||.||..:|.:          ..|.|:.||||||::.|.:.|..||:.|
  Rat   196 QKKRGDLRLIVASATLDAEKFRDFFNQNETSDPARDTCVILTVEGRTFPVDIFYLQSPVPDYIKA 260

  Fly   781 SLITVMQIHLREPPGDILLFLTGQEEIDTACEILYERMKSLGPD--VPELIILPVYSALPSEMQT 843
            ::.||::||..|..||||.|||||||::|...:|.|:.::|...  ...|.:||:|:.|||..|.
  Rat   261 TVDTVVKIHQTEGDGDILAFLTGQEEVETVVSMLIEQARALARTGMKKHLRVLPMYAGLPSFEQM 325

  Fly   844 RIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQR 908
            ::|:......|||::|||:||||:||.||.||:|.||:|.:.||.:|.::.|||.|:|||:|.||
  Rat   326 KVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQR 390

  Fly   909 AGRAGRTGPGKTYRLYTERAYRDEMLP-TPVPEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPV 972
            |||.||...||.||||||.|:  |.|| :.|||:||:|||..|||||.:||:.:|.|.||..||.
  Rat   391 AGRGGRNRSGKCYRLYTEEAF--EQLPQSTVPEMQRSNLAPVVLQLKALGIDSVLRFHFMSPPPA 453

  Fly   973 ESLVMALEQLHSLSALDDEGLLTR-LGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQ 1036
            :|:|.|||.|::|..||.:..||. ||.|:|||||.|..:|||:.|....||.|||:|.:|:.:|
  Rat   454 QSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQ 518

  Fly  1037 NVFYRPKDKQALADQKKAKFNQAEGDHLTLLAVYNSW-KNNKFSNAWCYENFVQIRTLKRSQDVR 1100
            |||..|.::::.|.:...||...||||||:|.||.:: |:|| |:.||.|:|:..:.|.|:..||
  Rat   519 NVFVFPSNQKSQATRVHRKFAVEEGDHLTMLNVYEAFIKHNK-SSQWCQEHFLNYKGLVRAATVR 582

  Fly  1101 KQLLGIMDRHKLDVVSAGKNSVRIQKAICSGFFRNAAKKDPQEGYRTLVDSQVVYIHPSSALF-N 1164
            .||..::.:.::..:|:..:...:.:.|.||||.|||:......|||:.|...::|||:|.|: .
  Rat   583 DQLKKLLVKFQVPKMSSEGDPDPVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAE 647

  Fly  1165 RQPEWVIYHELVQTTKEYMREVTTIDPKWLVEFAPSFFRFSDPTKLSKFKKNQRLE 1220
            :.|.||||:|::||:|.|||:||.|:..||:|.||.|::  ..|.||...|..:::
  Rat   648 KPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQ--QGTHLSLKAKRAKVQ 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	318/666 (48%)
Dhx35	XP_006235485.1	DEXDc	53..224	CDD:214692	96/170 (56%)
		DEXDc	73..211	CDD:238005	82/137 (60%)
		HELICc	301..396	CDD:197757	46/94 (49%)
		HA2	465..549	CDD:214852	39/83 (47%)
		OB_NTP_bind	584..683	CDD:285018	39/98 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730