DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and l(2)37Cb

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster

Alignment Length:	1002	Identity:	442/1002 - (44%)
Similarity:	605/1002 - (60%)	Gaps:	129/1002 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 RDRDRRHKSSSSRDHHERRRRSRSRSTERRDR---RDRSRDCSEKMPPPSAAMTDDPEAGKIYSG 290
            ::|.|...||||.:..:....||.:..:.||.   |.:.||             ||
  Fly     4 KNRKRTASSSSSGEEPDSEEESRLKDLQERDEFASRLKKRD-------------DD--------- 46

  Fly   291 KIANIVPFGCFVQLFGLRKRWEGLVHISQLRAEGRVTDVTEVVTRNQTVKVKVMSITGQKVSLSM 355
            :..|:      |...|.|:..|......:|..|.|    .::|..        :.:..::..|..
  Fly    47 RTRNV------VDSTGGRRAIEEATKRLKLEHEDR----DKIVPH--------LRLQSRRQYLEK 93

  Fly   356 KEVDQDSGKDLNPLSHAPEDDESLRDRNPDGPFSSSTSMLNLQGNGMEGDEHESRKRVTRISSPE 420
            ::.|:.:..:.:.|......|||:..:...........:||:      ..|||..:.:.||   :
  Fly    94 RKDDKVAELEADILDDEYLFDESVLTKREKEEREYKKQLLNI------AKEHEKARELERI---Q 149

  Fly   421 RWEIKQMISSGVLDRSEMPDFDEETGLLPKDEDDEADIEIEIVEEEPPFLSGHGRALHDLSPVRI 485
            |:.:.|.:..|  :|||..:.| |....|..|..:.:.|
  Fly   150 RYNMPQDLKKG--ERSEYVEVD-EFEKQPNSEQKKWEAE-------------------------- 185

  Fly   486 VKNPDGSLAQAAMMQSALSKERREQKMLQREQEIEAMPTSLNKNWIDPLPEDESRSLAANMRGMA 550
                  .||.|.....|...:..|:..|..:.:|:         :|..|..|.||..:::.:
  Fly   186 ------QLASARFHFGAKDAKAEEEYELLLDDQID---------FIQALTLDGSREKSSSRQ--- 232

  Fly   551 AAPPEVPEWKKHVIGGKKSSFGKKTDLTLVEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGK 615
               ||:.|             .::..|||.|.|:|||:|..::|||.||.::|:||:.|||||||
  Fly   233 ---PELTE-------------KERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGK 281

  Fly   616 TTQITQYLGECGFTARGK-IGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETII 679
            |||:.|||.|.|||...| |||||||||||||||.|||||.|.:||.||||:||||||||..||:
  Fly   282 TTQVPQYLVEAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTIL 346

  Fly   680 KYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDAV 744
            ||||||.|.||.|.|.:|.||||:::|||||||:|||:||||:|...:.||||||:::||||||.
  Fly   347 KYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAE 411

  Fly   745 KFSQYFFKAPIFTIPGRTFPVEVLYTKEPETDYLDASLITVMQIHLREPPGDILLFLTGQEEIDT 809
            |||.:|..||||.||||.:||::.|||.||.||:||..::|:|||..:|.||||:|||||:||:|
  Fly   412 KFSAFFDDAPIFRIPGRRYPVDIFYTKAPEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIET 476

  Fly   810 ACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFY 874
            ..|:|::|:|.||..:.|||::|||:.|||:||.:||:|.|..:|||::||||||||||||.|.|
  Fly   477 CQEVLHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIY 541

  Fly   875 VVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVP 939
            |:||||.||..:||:|||:||:|.|||:|:|.|||||||||.|||.:||||..||:.|:....||
  Fly   542 VIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVP 606

  Fly   940 EIQRTNLATTVLQLKTMGINDLLHFDFMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRRMAEF 1004
            ||||.||...||.||.:|||||:||||:|.||.|:||:|||||::|.||:..|.||:||||||||
  Fly   607 EIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEF 671

  Fly  1005 PLEPNLSKMLIMSVALQCSDEILTIVSMLSVQN-VFYRPKDKQALADQKKAKFNQAEGDHLTLLA 1068
            |::|.:.|||:.|...:||:|::||.:||||.: :|||||||...||..:..||...||||:||.
  Fly   672 PVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQ 736

  Fly  1069 VYNSWKNNKFSNAWCYENFVQIRTLKRSQDVRKQLLGIMDRHKLDVVSAGKNSVRIQKAICSGFF 1133
            |||.|....:|..||||||:|.|::||::|||:||:|:|.|.::|:||....:|.::||..:|:|
  Fly   737 VYNQWAETDYSTQWCYENFIQYRSMKRARDVREQLVGLMQRVEIDMVSCLPETVNVRKAATAGYF 801

  Fly  1134 RNAAKKDPQEGYRTLVDSQVVYIHPSSALFNRQPEWVIYHELVQTTKEYMREVTTIDPKWLVEFA 1198
            .:.|:......|:|:..:|.|.|||:|:||...|.||:|||||.|:|||||:|..|:.|||:|.|
  Fly   802 YHVARLSKGGHYKTIKHNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVA 866

  Fly  1199 PSFFRFSDPTKLSKFKKNQRLEPLYNK 1225
            |.::            |.:.||...||
  Fly   867 PHYY------------KAKELEDSTNK 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189	11/77 (14%)
pea	NP_610928.1	HrpA	573..1221	CDD:224557	376/649 (58%)
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	378/663 (57%)
		DEXDc	269..408	CDD:238005	97/138 (70%)
		HELICc	491..581	CDD:197757	58/89 (65%)
		HA2	651..735	CDD:214852	44/83 (53%)
		OB_NTP_bind	770..869	CDD:285018	46/98 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468086
Domainoid	1	1.000	55	1.000	Domainoid score	I637
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I130
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13788at6656
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		otm51353
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
	11	10.800