DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and dhx16

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_956318.1	Gene:	dhx16 / 336645	ZFINID:	ZDB-GENE-030131-8589	Length:	1054	Species:	Danio rerio

Alignment Length:	1229	Identity:	480/1229 - (39%)
Similarity:	682/1229 - (55%)	Gaps:	215/1229 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ICTELDNHLGINDKDLAEFIIDLENKNRTYDTFRKALLDNGAEFPDSLVQNLQRIINLMRPSRPG 80
            :..:|.:.||::|:.:|:|:|.|..|:.....|...|.|.|....|   |.:....:.:....|
Zfish     8 VSDQLHDILGLSDRYVAQFMIGLVQKSSGPQDFVSRLQDTGTIDID---QRITAFAHELYDKAP- 68

  Fly    81 GASQEKTVGDKKEDK-KSQLLKMFPGLALPNDTYSKKEESDDDEKVKAKPEKHSETHKKTDMSDV 144
                :|.|.:|.... :.|:::|    ...|.||:..|:|:                     ||.
Zfish    69 ----KKHVVEKPARAIERQVMEM----ERKNRTYTLLEDSE---------------------SDG 104

  Fly   145 DAAMMELEALAPGEGATLVRPHKEVSSRDRHKRRSRDRDTKRRSRSREDRHSDRRRSRSRDKERR 209
            :||.         ||.      ||..|::|.|.:.|....::|..|......|:::|.:...|.:
Zfish   105 EAAR---------EGG------KEKKSKERDKGKKRKHLRQKRDESPSSSEEDKKKSITFKDEPK 154

  Fly   210 RRSR--------SRDNRRRSRSREDRDRDRDRRHKSSSSRDHHERRRRSRSRSTERRDRRDRSRD 266
            :..:        .|..|.|.:..|:||...:|..:....:..:...|..:....|.:.|...:.:
Zfish   155 KAGKEDEEEEEWERGERERLQDLEERDAFAERVKQKDKDKTRNILERNDKKAYEEAQKRIKMAEE 219

  Fly   267 CSEKMPPPSAAMTDDPEAGKIYSGKIANIVPFGCFVQLFGLRKRWEGLVHISQLRAEGRVTDVTE 331
            ...||.|                                             :||.:.|    .:
Zfish   220 DKRKMLP---------------------------------------------ELRKQSR----RQ 235

  Fly   332 VVTRNQTVKVKVM--SITGQKVSLSMKEVDQDSGKDLNPLSHAPEDDESLRDRNPDGPFSSSTSM 394
            .:::.:..|::.:  .|..::...|.:.:.....|||       |...::||
Zfish   236 YLSKREQEKLEDLEAEIKDEEYLFSTQNLTDRERKDL-------EYKRTIRD------------- 280

  Fly   395 LNLQGNGMEGDEHESRKRVTRISSPERWEIKQMISSGVLDRSEMPDFDEETGLLPKDEDDEADIE 459
                          ..|...:..:.|:.|.|        :|..||:......:..||.|.|
Zfish   281 --------------MAKEYKKAGAKEQEERK--------NRYYMPEEKRNKSIPQKDMDLE---- 319

  Fly   460 IEIVEEEPPFLSGHGRALHDLSPVRIVKNPDGSLAQAAMMQSAL---SKERREQKMLQREQEIEA 521
               .||.|  ..|.|.              .|...:|.:..:.|   :::.||:::.:.::..:.
Zfish   320 ---FEETP--REGGGE--------------QGRWEEARVATATLQFGARQERERRIKEEQERYQL 365

  Fly   522 MPTSLNKNWIDPLPEDES---RSLAANMRGMAAAPPEVPEWKKHVIGGKKSSFGKKTDLTLVEQR 583
            :           |.|:|.   .|.|..|:|..:.....||          .|..:|...::.|.|
Zfish   366 I-----------LEEEEMITFVSTAITMKGTLSEKESEPE----------LSQAEKQKQSIQEVR 409

  Fly   584 QSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTARG-KIGCTQPRRVAAMSV 647
            :||||:..|:||:.|:.|:|||::.|||||||||||.|||.|.|:|..| |||||||||||||||
Zfish   410 RSLPIFPYREDLLAAIGDHQILVIEGETGSGKTTQIPQYLLEEGYTKGGMKIGCTQPRRVAAMSV 474

  Fly   648 AKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERT 712
            |.|||:|...:||.||||:||||||||..||:|||||||||||.|.|.:|.|||||::|||||||
Zfish   475 AARVAQEMSVKLGNEVGYSIRFEDCTSERTILKYMTDGMLLREFLTEPDLASYSVIIIDEAHERT 539

  Fly   713 IHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTFPVEVLYTKEPETDY 777
            :|||:||||:|...:.||:||::|.|||||..:||.:|..||:|.||||.|||::.|||.||.||
Zfish   540 LHTDILFGLIKDIARFRPDLKVLVASATLDTERFSSFFDDAPVFRIPGRRFPVDIYYTKAPEADY 604

  Fly   778 LDASLITVMQIHLREPPGDILLFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQ 842
            |:|.:::|:|||:.:.|||:|:||||||||:..||:|.||.:.||..:.||::||:|:.|||:||
Zfish   605 LEACVVSVLQIHVTQSPGDVLVFLTGQEEIEACCELLQERCRRLGSKISELLVLPIYANLPSDMQ 669

  Fly   843 TRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQ 907
            .:||:|.|.|:||||:||||||||||||||.||:||||.|||.||:||||:||:|||.|:|:|.|
Zfish   670 AKIFNPTPPGARKVVVATNIAETSLTIDGIIYVIDPGFCKQKSYNAKTGMESLIVTPCSRASANQ 734

  Fly   908 RAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPV 972
            |||||||...||.:||||..|::.||..|.|||||||||...||.||::|||||:||||||.||.
Zfish   735 RAGRAGRVAAGKCFRLYTAWAFKHEMEETTVPEIQRTNLGNVVLLLKSLGINDLIHFDFMDPPPH 799

  Fly   973 ESLVMALEQLHSLSALDDEGLLTRLGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQN 1037
            |:||:|||||::|.||:..|.||:|||||||.|::|.||||::.|...:||:|:|||.:||||.|
Zfish   800 ETLVLALEQLYALGALNHLGELTKLGRRMAELPVDPMLSKMILASEQYKCSEEVLTIAAMLSVNN 864

  Fly  1038 -VFYRPKDKQALADQKKAKFNQAEGDHLTLLAVYNSWKNNKFSNAWCYENFVQIRTLKRSQDVRK 1101
             :|||||||...||..:..|....||||.||.||..|..:.:|..||:|||:|.|::||::|||.
Zfish   865 SIFYRPKDKVVHADNARMNFVVPGGDHLVLLNVYTQWVESGYSTQWCFENFIQFRSMKRARDVRD 929

  Fly  1102 QLLGIMDRHKLDVVSAGKNSVRIQKAICSGFFRNAAKKDPQEGYRTLVDSQVVYIHPSSALFNRQ 1166
            ||.|:|||.::::.|:..:|:.|:||:.:|:|.:.|:.. :.||:|:...|.||:||:|:||..|
Zfish   930 QLEGLMDRIEVELCSSNGDSMPIRKAVTAGYFYHTARLS-KGGYKTVKHQQTVYVHPNSSLFEEQ 993

  Fly  1167 PEWVIYHELVQTTKEYMREVTTIDPKWLVEFAPSFFRFSDPTKLSKFKKNQRLEPLYNK 1225
            |.|:||||||.||||:||:|..|:..||:|.||.::            ||:.||...:|
Zfish   994 PRWMIYHELVFTTKEFMRQVIEIESGWLLEVAPHYY------------KNKELEDSSSK 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189	6/79 (8%)
pea	NP_610928.1	HrpA	573..1221	CDD:224557	379/649 (58%)
dhx16	NP_956318.1	BLVR	<94..>142	CDD:283923	17/83 (20%)
		GBP_C	<177..296	CDD:303769	24/201 (12%)
		coiled coil	271..285	CDD:293879	6/47 (13%)
		DEXDc	407..594	CDD:214692	125/186 (67%)
		DEXDc	429..568	CDD:238005	98/138 (71%)
		Helicase_C	612..742	CDD:278689	86/129 (67%)
		HA2	811..895	CDD:214852	45/83 (54%)
		OB_NTP_bind	916..1028	CDD:285018	54/112 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.730