DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and dhx15

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_001108613.1	Gene:	dhx15 / 321931	ZFINID:	ZDB-GENE-030131-650	Length:	769	Species:	Danio rerio

Alignment Length:	842	Identity:	372/842 - (44%)
Similarity:	518/842 - (61%)	Gaps:	107/842 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 GDEHESRKRVTRISSPERWEIKQMISSGVLDRSEMPDFDEETGLLPKDEDDEADIEIEIVEEEPP 468
            |||:.|.|:               .||...||..  |.||.:    ||.|.:.|.|.:
Zfish    10 GDEYSSSKK---------------RSSDGKDRDR--DRDERS----KDRDRDRDRERD------- 46

  Fly   469 FLSGHGRALHDLSPVRIVKNPDGSLAQAAMMQSALSKERREQKMLQREQEIE----AMPTSLNKN 529
                                                ::|...:...||::.:    |:.:|::.:
Zfish    47 ------------------------------------RDRDRDRDRDRERDSKSSSAALSSSVSGS 75

  Fly   530 WIDPLPEDESRSLAANMRGMAAAPPEVPEWKKHVIGGKKSSFGKKTDLTLVEQRQSLPIYKLRDD 594
            .|.||.:       |:|.........:|...::              ..::::|..||:::.::.
Zfish    76 GILPLKQ-------ASMHQQINPFTNLPHTPRY--------------YEILKKRLQLPVWEYKER 119

  Fly   595 LIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTARGK---IGCTQPRRVAAMSVAKRVAEEYG 656
            ....:..:|..:::|||||||||||.|:..:...:..|.   :.|||||||||||||:|||:|..
Zfish   120 FNDILNRHQSFVLVGETGSGKTTQIPQWCVDMVRSLPGPKRGVACTQPRRVAAMSVAQRVADEMD 184

  Fly   657 CRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGL 721
            ..|||||||:||||||:|.:||:|||||||||||.:.:..|:.|.||:||||||||:.||:|.|:
Zfish   185 VMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATDILMGV 249

  Fly   722 LKTAVQKRPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTFPVEVLYTKEPETDYLDASLITVM 786
            ||..|::|.:||:||.||||||.||..||...|:.||||||.|||:.||.|||.|||:|::.||:
Zfish   250 LKEVVRQRSDLKVIVMSATLDAGKFQVYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVI 314

  Fly   787 QIHL-REPPGDILLFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAP 850
            |||: .|..||:|||||||||||.||:.:...:..|||||.::.|:|:||.||.:.|.|||:|.|
Zfish   315 QIHMCEEDEGDVLLFLTGQEEIDEACKRIKREIDDLGPDVGDIKIIPLYSTLPPQQQQRIFEPPP 379

  Fly   851 ------AGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRA 909
                  |..||||::||||||||||||:.:|:||||.||||||.:..::||:||.||:|:|:|||
Zfish   380 PRKPNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRA 444

  Fly   910 GRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPVES 974
            ||||||.|||.:|||||:||:.||.....|||.|:||.:.|||||.:||:||:||||||.|..|:
Zfish   445 GRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPET 509

  Fly   975 LVMALEQLHSLSALDDEGLLTRLGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVF 1039
            |:.|||.|:.|:||:|:|.||.||..||||||:|.|:||:|.|....||:|:|:|.:||||...|
Zfish   510 LMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDFNCSNEVLSITAMLSVPQCF 574

  Fly  1040 YRPKDKQALADQKKAKFNQAEGDHLTLLAVYNSWKNNKFSNAWCYENFVQIRTLKRSQDVRKQLL 1104
            .||.:.:..||:.|.:|...:|||||||.||:::|.|..|..|||:||:..|:|..:.:||:||.
Zfish   575 VRPTEAKKAADESKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSADNVRQQLS 639

  Fly  1105 GIMDRHKLDVVSAGKNS----VRIQKAICSGFFRNAAKKDPQEGYRTLVDSQVVYIHPSSALFNR 1165
            .||||..|...|....|    :.|::|:.:|||...|..:....|.|:.|:|||.:|||:.| :.
Zfish   640 RIMDRFNLPRRSTEFTSRDYYINIRRALVTGFFMQVAHLERTGHYLTVKDNQVVQLHPSTVL-DH 703

  Fly  1166 QPEWVIYHELVQTTKEYMREVTTIDPKWLVEFAPSFFRFSDPTKLSKFKKNQRLEPLYNKYE 1227
            :||||:|:|.|.|||.|:|..|.|.|:|||:.||.::..|:   ..:.:..::||.:..|.:
Zfish   704 KPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAPQYYEMSN---FPQCEAKRQLERIVAKLQ 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	342/661 (52%)
dhx15	NP_001108613.1	DEXDc	105..296	CDD:214692	105/190 (55%)
		DEXDc	128..269	CDD:238005	84/140 (60%)
		HELICc	356..449	CDD:197757	54/92 (59%)
		HA2	519..602	CDD:214852	42/82 (51%)
		OB_NTP_bind	636..739	CDD:285018	45/103 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.730